Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 Proteins (CYP2C19)

CYP2C19 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2C19 Antibodies (33) and CYP2C19 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP2C19 1557 P33261
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Top CYP2C19 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Yeast (Pichia pastoris) Human Un-conjugated   10 mg Log in to see 2 to 3 Days
$125.00
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

CYP2C19 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 (CYP2C19) Interaction Partners

Human Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 (CYP2C19) interaction partners

  1. Genetic testing of CYP2C19 may help in prescribing a dose according to genetic makeup and represent the initial steps towards the development of diagnostic tests and therapeutic strategies that will substantially improve human health.

  2. rs4244285 of CYP2C19 have the main effects on coronary heart disease risk.

  3. The poor metabolizer (PM) group had the lowest metabolic ratio and exhibited the highest area under the curve (AUC) for omeprazole among the CYP2C19 phenotype groups.

  4. The carriage of the cytochrome P450 CYP2C19 681A allele rather than platelet receptor gene polymorphisms increased extent of platelet aggregation induced by dual antiplatelet therapy in patients with Coronary heart disease .

  5. coadministration, voriconazole AUC and Cmin decreased by 33% and 39% respectively, in CYP2C19 extensive-metabolizers, whereas voriconazole Cmax and AUC increased 4.4-fold and 5.6-fold respectively, in poor-metabolizers

  6. individuals with both the CYP2C19*2 allele and hypertension are at high risk of Clopidogrel Resistance during anti-thrombosis therapy.

  7. NXT (show NXT1 Proteins) leaded to a significant enhancement of the CYP2C19 catalytic activity in PXR (show NR1I2 Proteins)-transfected HepG2 cells

  8. The aim of this study was to clarify the catalytic activities of 31 CYP2C19 alleles on the oxidative in vitro metabolism of methadone. Methadone, as a CYP2C19-specific substrate, was used to systematically analyze the enzymatic characteristics of 31 CYP2C19 alleles found in the Chinese population, and offer valuable information relevant to the personalized medicine for CYP2C19-metabolized drugs in China.

  9. apart from the established association of the CYP2C19 *2 and *3 LOF alleles with high on-treatment platelet reactivity (HTPR), haplotypes of P2RY12 rs6798347, rs6787801, rs6801273, and rs6785930 rather than rs2046934 (T744C) that related to pharmacodynamics of clopidogrel in patients with ACS were independently associated with HTPR

  10. CYP2C19 poor metabolizer genotype may be a new candidate risk factor for coronary microvascular disorder via inflammation exclusively in the female population.

CYP2C19 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Gene names and symbols associated with CYP2C19

  • cytochrome P450, family 2, subfamily C, polypeptide 19 (CYP2C19)
  • CPCJ protein
  • CYP2C protein
  • P450C2C protein
  • P450IIC19 protein

Protein level used designations for CYP2C19

cytochrome P450 2C , (R)-limonene 6-monooxygenase , (S)-limonene 6-monooxygenase , (S)-limonene 7-monooxygenase , CYPIIC17 , CYPIIC19 , S-mephenytoin 4-hydroxylase , cytochrome P-450 II C , cytochrome P450 2C19 , cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19 , cytochrome P450-11A , cytochrome P450-254C , flavoprotein-linked monooxygenase , mephenytoin 4'-hydroxylase , mephenytoin 4-hydroxylase , microsomal monooxygenase , xenobiotic monooxygenase

GENE ID SPECIES
510380 Bos taurus
1557 Homo sapiens
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