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CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Kits (47) and Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Proteins (24) and many more products for this protein.
Showing 10 out of 181 products:
Mouse (Murine) Polyclonal CYP2E1 Primary Antibody for IHC (p), WB - ABIN3044118
Fan, Jiang, Wang, Tan, Zeng, Wang, Chen, Qu, Gonzalez, Huang, Bi: Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. in Drug metabolism and disposition: the biological fate of chemicals 2014
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Human Polyclonal CYP2E1 Primary Antibody for IHC (p), WB - ABIN3043821
Jiang, Fan, Wang, Chen, Zeng, Tan, Gonzalez, Huang, Bi: Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. in Toxicological sciences : an official journal of the Society of Toxicology 2014
Show all 3 Pubmed References
Human Polyclonal CYP2E1 Primary Antibody for WB - ABIN3043000
Chen, Sun, Han, Peng, Li, Liu, Lv, Liu, Zhou, Sun: Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression. in World journal of gastroenterology 2009
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Human Polyclonal CYP2E1 Primary Antibody for ELISA, IHC - ABIN4302103
Niu, Yuan, Leng, Pang, Gu, Chen: CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer risk: a meta-analysis based on 1,088 cases and 2,238 controls. in Medical oncology (Northwood, London, England) 2011
Human Polyclonal CYP2E1 Primary Antibody for IHC, IHC (p) - ABIN4302106
Hou, Bukong, Kodys, Szabo: Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells. in Alcoholism, clinical and experimental research 2013
Human Polyclonal CYP2E1 Primary Antibody for IHC, IHC (p) - ABIN4302104
Fagerberg, Hallström, Oksvold, Kampf, Djureinovic, Odeberg, Habuka, Tahmasebpoor, Danielsson, Edlund, Asplund, Sjöstedt, Lundberg, Szigyarto, Skogs, Takanen, Berling, Tegel, Mulder, Nilsson, Schwenk et al.: Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. ... in Molecular & cellular proteomics : MCP 2014
Human Polyclonal CYP2E1 Primary Antibody for WB - ABIN514837
De Bock, Colin, Boussery, Van Bocxlaer: Quantification of cytochrome 2E1 in human liver microsomes using a validated indirect ELISA. in Journal of pharmaceutical and biomedical analysis 2013
The localization of CYP1A2 (show CYP1A2 Antibodies), CYP2B4 and CYP2E1 within the ER was determined by partial membrane solubilization with Brij 98
We identified an exposure-associated differentially methylated region (DMR (show WDR20 Antibodies)) spanning nine sequential CpG sites in the promoter-regulatory region of the cytochrome P450 2E1 gene (CYP2E1) on chromosome 10 (corrected P=2.98 x 10(-5)). Elevated DNA methylation (show HELLS Antibodies) across this region was also associated with deprivation-related clinical markers of impaired social cognition.
A significant increase in the risk of non-small cell lung cancer was observed for the following combinations: TP53 (show TP53 Antibodies) codon72 variant with GSTM1 (show GSTM1 Antibodies) null (OR 2.22, 95 % CI 1.23-4.04; p=0.009), GSTT1 (show GSTT1 Antibodies) null (OR 2.98, 95 % CI 1.49-5.94; p=0.002), and GSTP1 (show GSTP1 Antibodies) (Ala114Val) variant genotypes (OR 3.38, 95 % CI 1.54-7.41; p=0.002).
Studied the possible relationship between cytochrome P450 (show CYP Antibodies), family 2, subfamily E and polypeptide 1 (show CYP Antibodies) (CYP2E1) polymorphisms with Kawasaki disease (KD). Found the KD patients with a CYP2E1 CC genotype of rs915906 demonstrated a greater proportion of coronary artery lesions (CALs (show CA8 Antibodies)) formation.
The results suggest that changes in coumarin pharmacokinetics and CYP2E1 subcellular distribution contribute to resistance to coumarin-induced hepatic necrosis, while cytotoxicity of metabolic conjugates shown in vitro may contribute to bile duct damage upon repeated coumarin administration.
Data suggest a homeostatic, gene dosage-insensitive regulation of CYP2E1 expression by unknown gene dosage compensation mechanisms.
Data suggest that microRNA-214-3p (but not microRNA-942-5p) suppresses expression of CYP2E1 in hepatocytes; microRNA-214-3p interacts with two binding sites located in protein coding region of CYP2E1 mRNA. (CYP2E1 = cytochrome P450 (show CYP Antibodies) family 2 subfamily E member 1)
The synergistic effect of VK2 and EtOH was also observed in QGY-7703 cells, which also express CYP2E1. However, in HepG2 cells, which do not express CYP2E1, the synergistic effect of VK2 and EtOH was not observed
The results suggest that there is no evidence for a major role of CYP2E1 polymorphism in liver carcinogenesis, but do not rule out the possibility in certain cases. [meta-analysis]
The CYP2E1-PPARalpha (show PPARA Antibodies) axis may play a role in ethanol-induced neurotoxicity via the alteration of the genes related with synaptic function
Results demonstrated that CYP2E1*5B and CYP2E1*6 minor alleles play a role in the development of sporadic colorectal neoplasms.
we show that TRPV4 (show TRPV4 Antibodies) is activated both by damage associated molecular pattern HMGB1 (show HMGB1 Antibodies) and collagen in diseased Kupffer cells that in turn activate the endothelial NOS (NOS3 (show NOS3 Antibodies)) to release nitric oxide (NO). The diffusible NO acts in a paracrine fashion in neighboring hepatocytes to deactivate the redox toxicity induced by CYP2E1
Data, including data from studies in knockout mice, suggest that the oxidative metabolism of 1,2-dichloropropane, a carcinogenic solvent/insecticide, is exclusively catalyzed by Cyp2e1; this biotransformation step is indispensable for manifestation of hepatotoxic effect of the solvent.
Taken together, these results suggested that 1,2-dichloroethane (1,2-DCE (show DHCR24 Antibodies)) could enhance CYP2E1 protein expression and enzymatic activity, which could cause oxidative damage in liver, serving as an important mechanism underlying 1,2-DCE (show DHCR24 Antibodies)-induced liver damage
CYP2E1 is important in causing aging-dependent hepatic steatosis, apoptosis and fibrosis possibly through increasing nitroxidative stress.
Our results support a significant role for CYP2E1 as a novel 4-Aminobiphenyl N-oxidizing enzyme in adult mice
Schisandrol B protects against APAP-induced liver injury, potentially through inhibition of CYP2E1/3A11-mediated APAP bioactivation and regulation of the p53 (show TP53 Antibodies), p21 (show D4S234E Antibodies), CCND1 (show CCND1 Antibodies), PCNA (show PCNA Antibodies), and BCL-2 (show BCL2 Antibodies) to promote liver regeneration.
Studied hepatic stellate cell cytoglobin (show CYGB Antibodies) involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1.
Data suggest that expression of Cyp2e1 in adipose tissue can be regulated by dietary factors; here, expression of Cyp2e1 in white adipose tissue is down-regulated in obesity caused by high-fat diet.
The Cyp2e1-null mice displayed a susceptibility to lung toxicity of styrene similar to that of the wild-type animals; however, Cyp2f2-null mice were resistant to styrene-induced pulmonary toxicity.
significant increases in Col1a1 (show COL1A1 Antibodies), serine/threonine-protein kinase 1, Ctnnb1 (show CTNNB1 Antibodies), CSRNP1 (show CSRNP1 Antibodies), Ddit4 (show DDIT4 Antibodies), Cyp2e1, and Krit1 (show KRIT1 Antibodies) expressions and great decreases inreceptor D2, Neu1 (show NEURL Antibodies), and Dhcr7 (show DHCR7 Antibodies) expressions following long-term exposure to TiO2 NPs (show NPS Antibodies)
A highly significant association was found between variation in skatole levels and SNPs within the CYP2E1 gene on chromosome 14.
The relationship between a single nucleotide polymorphism of CYP2E1 and boar taint in pork from Belgian swine is reported.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
cytochrome P450 2E1
, 4-nitrophenol 2-hydroxylase
, Cytochrome P450 2E1
, Cytochrome P450 LM3A
, Cytochrome P450 isozyme 3A
, Cytochrome P450-ALC
, Cytochrome P450-J
, cytochrome P-450j
, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
, cytochrome P450-J
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, xenobiotic monooxygenase
, cytochrome P450, 2e1, ethanol inducible
, cytochrome P450-ALC
, cytochrome P450 subfamily 2e1 (ethanol-inducible)
, cytochrome P450, subfamily 2E, polypeptide 1
, cytochrome P450RLM6
, cytochrome P-450-J
, cytochrome P450 CYP2E1