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Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Proteins (CYP46A1)

CYP46A1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Antibodies (58) and Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP46A1 10858 Q9Y6A2
CYP46A1 13116 Q9WVK8
Rat CYP46A1 CYP46A1 362782  
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Top Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CYP46A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) Interaction Partners

Human Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) interaction partners

  1. hippocampal CYP46A1 protein and 24S-hydroxycholesterol levels were reduced in a mouse model of Alzheimer's Disease-like Tau neuropathology

  2. under conditions of membrane cholesterol reduction by increased CYP46A1 expression, neurons increase isoprenoid synthesis and sGTPase prenylation. This leads to a reduction in liver X receptor activity

  3. Human CYP46A1 oxidizes 7-dehydrocholesterol to 24-hydroxy-7-dehydrocholesterol and 25-hydroxy-7-dehydrocholesterol.

  4. While there were no differences in cognitive performance between participants with and those without metabolic syndrome, ApoE (show APOE Proteins) and CYP46 genotypes did correlate with mental manipulation scores.

  5. results of meta-analysis suggested that CYP46A1 rs754203 is a minor risk factor for Alzheimer's disease

  6. An meta-analysis has successfully proved that CC genotype of the CYP46A1 T/C polymorphism could increase the risk of Alzheimer's disease.

  7. A meta-analysis indicates that the CYP46 gene SNP rs754203 is not significantly associated with sporadic Alzheimer's disease susceptibility in Chinese Han populations.

  8. To identify the determinants of tight azole binding to CYP46A1.

  9. analysis of binding of the cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1

  10. The intronic polymorphism in CYP46A1 is associated with Alzheimer disease in a Chinese Han population, and the CYP46A1 T allele might be a risk factor.

Cow (Bovine) Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) interaction partners

  1. EFV enhanced CYP46A1 activity and cerebral cholesterol turnover in animals with no effect on the levels of brain cholesterol.

  2. analysis of binding of the cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1

Mouse (Murine) Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) interaction partners

  1. Increased expression of CYP46A1 in the striatum decreased neuronal atrophy in a Huntington's disease model.

  2. under conditions of membrane cholesterol reduction by increased CYP46A1 expression, neurons increase isoprenoid synthesis and sGTPase prenylation. This leads to a reduction in liver X receptor activity

  3. EFV enhanced CYP46A1 activity and cerebral cholesterol turnover in animals with no effect on the levels of brain cholesterol.

  4. the CYP46 gene locus may predispose to Alzheimer's disease by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain.

  5. The expression of CYP46A1, as well as other cytochrome P450s involved in cholesterol homeostasis, are potently regulated by histone acetylation status.

Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1) Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Gene names and symbols associated with CYP46A1

  • cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1)
  • cytochrome P450, family 46, subfamily A, polypeptide 1 (cyp46a1)
  • cytochrome P450, family 46 (cyp46a1)
  • cytochrome P450 46A1 (PTRG_08343)
  • cytochrome P450 46A1 (PTRG_09667)
  • cholesterol 24-hydroxylase (Sgly_1093)
  • cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1)
  • CP46 protein
  • Cyp46 protein
  • CYP46A1 protein
  • MGC147389 protein
  • zgc:109896 protein

Protein level used designations for CYP46A1

cholesterol 24-hydroxylase , cytochrome P450, family 46, subfamily A, polypeptide 1 , cytochrome P450, family 46 , cytochrome P450 46A1 , CH24H , cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) , cholesterol-24S-hydroxylase , cholestrol 24-hydroxylase , cytochrome P450, 46 (cholesterol 24-hydroxylase) , cytochrome P450, 46a1 (cholesterol 24-hydroxylase)

GENE ID SPECIES
423450 Gallus gallus
453154 Pan troglodytes
553543 Danio rerio
780005 Xenopus (Silurana) tropicalis
100145328 Xenopus (Silurana) tropicalis
6346625 Pyrenophora tritici-repentis Pt-1C-BFP
6347960 Pyrenophora tritici-repentis Pt-1C-BFP
10248273 Syntrophobotulus glycolicus DSM 8271
10858 Homo sapiens
379470 Xenopus laevis
506438 Bos taurus
13116 Mus musculus
362782 Rattus norvegicus
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