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Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 Proteins (CYP7A1)

CYP7A1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP7A1 Kits (50) and CYP7A1 Antibodies (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP7A1 1581 P22680
CYP7A1 13122 Q64505
CYP7A1 25428 P18125
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Top CYP7A1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$823.90
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$806.30
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,426.50
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CYP7A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)
,
Rat (Rattus) ,
,

More Proteins for Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 (CYP7A1) Interaction Partners

Human Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 (CYP7A1) interaction partners

  1. Macrophage cholesterol efflux in patients with type II diabetes mellitus was significantly reduced, and that this reduction was associated with the down-regulation of CYP7A1 expression.

  2. CYP7A1 and APOE (show APOE Proteins) isoform are associated with the extent of reduction in circulating LDL cholesterol in response to plant sterols consumption.

  3. The CYP7A1 rs7833904 polymorphism may modify the risk of CAD.

  4. The CYP7A1 crystallographic models identify residues involved in cholest-4-en-3 (show EN1 Proteins)-one binding.

  5. we identified for the first time a significant association of the A-204C polymorphism of the CYP7A1 gene and development of tuberculosis in a Moroccan population

  6. The CYP7A1 -204A>C polymorphism is significantly associated with serum lipid levels in Asian population, but not gallbladder stone disease. [Meta-analysis]

  7. Cyp7a1 is a direct Thyroid hormone receptor (show THRA Proteins) (TR) target gene that responds to physiologic TR levels through a set of distinct response elements in its promoter.

  8. Activation of the VDR (show CYP27B1 Proteins) represses hepatic SHP (show LAMC1 Proteins) to increase levels of CYP7A1 and reduce cholesterol.

  9. Two known single nucleotide polymorphisms were identified in the 5'-UTR of CYP7A1 and both were associated with neuromyelitis optica but not with Multiple sclerosis.

  10. Genetic variants of CYP7A1 and its transcriptional activators (HNF4A and PPARGC1A) may activate bile acid synthesis, resulting in the accumulation of bile acids in hepatocytes leading primary biliary cirrhosis progression.

Mouse (Murine) Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 (CYP7A1) interaction partners

  1. Mice deficient in cholesterol 7 alpha-hydroxylase, supplemented with chenodeoxycholic acid, have altered liver and intestinal bile acids.

  2. Activation of the VDR (show CYP27B1 Proteins) represses hepatic SHP (show LAMC1 Proteins) to increase levels of CYP7A1 and reduce cholesterol.

  3. Cholesterol lowering properties of oats involve increased production of bile acids via the classic pathway with up-regulation of CYP7A1 and CYP8B1 (show CYP8B1 Proteins).

  4. A CYP7A1/SREBP2 (show SREBF2 Proteins)/miR (show MLXIP Proteins)-33a axis plays a critical role in regulation of hepatic cholesterol, bile acid, and fatty acid synthesis.

  5. Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt (show SLC10A2 Proteins)(-/-)apoE (show APOE Proteins)(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1).

  6. HNF4alpha (show HNF4A Proteins) and LRH-1 (show NR5A2 Proteins) promote active transcription histone marks on the Cyp7a1 promoter that are reversed by FGF19 (show FGF19 Proteins) in a SHP (show LAMC1 Proteins)-dependent manner

  7. these data suggest that FGF7 (show FGF7 Proteins) is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis.

  8. Results indicate that although PPARgamma (show PPARG Proteins) activation increased PCSK9 (show PCSK9 Proteins) expression, PPARgamma (show PPARG Proteins) activation induced LDLR (show LDLR Proteins) and CYP7A1 expression that enhanced LDL cholesterol metabolism.

  9. Cyanidin-3-O-beta-glucoside consumption reduced hypercholesterolemia, promoted fecal bile acid excretion and upregulated hepatic cholesterol 7a-hydroxylase expression (CYP7A1).

  10. Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice

Pig (Porcine) Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 (CYP7A1) interaction partners

  1. the effect of polymorphism in the cholesterol 7-alpha hydroxylase gene locus and dietary cholesterol on cerebrum cholesterol in neonatal pigs fed sow's milk formulas are reported.

CYP7A1 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis.

Gene names and symbols associated with CYP7A1

  • cholesterol 7-alpha-hydroxylase (Cyp7a1)
  • cytochrome P450, family 7, subfamily A, polypeptide 1 (CYP7A1)
  • cytochrome P450, family 7, subfamily a, polypeptide 1 (Cyp7a1)
  • CHAP protein
  • CP7A protein
  • CYP7 protein
  • CYP7S1 protein
  • CYPVII protein

Protein level used designations for CYP7A1

cholesterol 7-alpha-hydroxylase , cholesterol 7-alpha-monooxygenase , cytochrome P450 7A1 , cytochrome P450, subfamily VIIA polypeptide 1 , CYPVII , cholesterol 7 alpha hydroxylase , cytochrome P450, 7a1 , cholesterol 7-alpha hydroxylase , cytochrome P450 (cholesterol hydroxylase 7 alpha) , cholesterol 7alpha-hydroxylase , cholesterol 7 alpha-hydroxylase

GENE ID SPECIES
100337633 Cavia porcellus
1581 Homo sapiens
13122 Mus musculus
25428 Rattus norvegicus
448985 Sus scrofa
100328551 Oryctolagus cuniculus
414834 Gallus gallus
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