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anti-Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1) Antibodies

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Additionally we are shipping CYP8B1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYP8B1 81924  
CYP8B1 1582 Q9UNU6
CYP8B1 13124 O88962
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Top anti-CYP8B1 Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CYP8B1 Antibody (C-term) in K562 cell line lysates (35ug/lane). CYP8B1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CYP8B1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate WB Suggested Anti-CYP8B1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CYP8B1 Antibody (C-term) (ABIN652734) in K562 cell line lysates (35 µg/lane). CYP8B1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with MAPRE1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Cytochrome P450 8B1 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated IHC   100 μL Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB   400 μL Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated WB Western Blot showing CYP8B1 antibody used at a concentration of 1-2 ug/ml to detect its target protein. 50 μg Log in to see 7 to 9 Days
$473.93
Details

CYP8B1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)


Human , ,


Mouse (Murine)


Top referenced anti-CYP8B1 Antibodies

  1. Human Polyclonal CYP8B1 Primary Antibody for IHC, ELISA - ABIN1452042 : Gåfvels, Olin, Chowdhary, Raudsepp, Andersson, Persson, Jansson, Björkhem, Eggertsen: Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. in Genomics 1999 (PubMed)
    Show all 2 references for ABIN1452042

  2. Human Polyclonal CYP8B1 Primary Antibody for EIA, WB - ABIN453612 : Zhang, Chiang: Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression. in The Journal of biological chemistry 2001 (PubMed)

More Antibodies against CYP8B1 Interaction Partners

Human Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1) interaction partners

  1. RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum and liver cholesterol levels.

  2. The single nucleotide polymorphism rs3732860 in the 3'-untranslated region of the CYP8B1 gene is associated with risk of Gallstone Disease in Chinese Han.

  3. SNP rs3732860 of CYP8B1 gene is associated with gallstone disease in this Chinese population.

  4. Cholesterol loading reduces SREBP-1 (show SREBF1 Antibodies) mRNA expression in addition to reducing functional SREBP-1 (show SREBF1 Antibodies) protein, and results in decreasing CYP8B1 gene transcription.

  5. Studies indicate a homogenous pattern for CYP8B1 expression in human liver, which was even rather than zonal.

  6. T(3) dose-dependently decreased total bile acid formation in parallel with decreased expression of CYP7A1 (show CYP7A1 Antibodies) and CYP8B1

  7. Isoflavone-related induction of 12-alpha-hydroxylase (CYP8B1) was studied in vitro and murine in vivo models.

Mouse (Murine) Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1) interaction partners

  1. Absence of Cyp8b1 results in improved glucose tolerance, insulin (show INS Antibodies) sensitivity, and beta-cell function, mediated by absence of cholic acid in Cyp8b1(-/-) mice.

  2. Cholesterol lowering properties of oats involve increased production of bile acids via the classic pathway with up-regulation of CYP7A1 (show CYP7A1 Antibodies) and CYP8B1.

  3. RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum and liver cholesterol levels.

  4. Feedback regulation of the rate-limiting biosynthetic enzyme CYP7A1 (show CYP7A1 Antibodies) is lost in Cyp8b1(-/-) mice, causing expansion of the bile acid pool and alterations in cholesterol metabolism.

  5. In the intercross between C57BL/6J and CASA (show CSN1S1 Antibodies)/Rk mice, Cyp8b1 is not responsible for biliary bile acid composition.

  6. The expression pattern of Cyp8b1 was studied in hepatocytes.

  7. Isoflavone-related induction of 12-alpha-hydroxylase (CYP8B1) was studied in vitro and murine in vivo models.

CYP8B1 Antigen Profile

Protein Summary

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.

Gene names and symbols associated with CYP8B1

  • cytochrome P450, family 8, subfamily b, polypeptide 1 (Cyp8b1) antibody
  • cytochrome P450, family 8, subfamily B, polypeptide 1 (cyp8b1) antibody
  • cytochrome P450, family 8, subfamily B, polypeptide 1 (CYP8B1) antibody
  • CP8B antibody
  • CYP8B antibody
  • CYP12 antibody
  • MGC64456 antibody

Protein level used designations for CYP8B1

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase , cytochrome P450 8b1 sterol 12 alpha-hydrolase , cytochrome P450, 8b1, sterol 12 alpha-hydrolase , cytochrome P450, family 8, subfamily B, polypeptide 1 , cytochrome P450, family 8, subfamily B , 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase , 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase , CYPVIIIB1 , cytochrome P450 8B1 , cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1 , sterol 12-alpha-hydroxylase , sterol 12-alpha-hydrolase , sterol 12-alpha hydroxylase

GENE ID SPECIES
81924 Rattus norvegicus
379482 Xenopus laevis
425055 Gallus gallus
538964 Bos taurus
1582 Homo sapiens
13124 Mus musculus
100009301 Oryctolagus cuniculus
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