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Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 Proteins (CYP8B1)

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Additionally we are shipping CYP8B1 Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CYP8B1 CYP8B1 81924  
CYP8B1 1582 Q9UNU6
CYP8B1 13124 O88962
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Top CYP8B1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,415.50
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CYP8B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1) Interaction Partners

Human Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1) interaction partners

  1. RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum and liver cholesterol levels.

  2. The single nucleotide polymorphism rs3732860 in the 3'-untranslated region of the CYP8B1 gene is associated with risk of Gallstone Disease in Chinese Han.

  3. SNP rs3732860 of CYP8B1 gene is associated with gallstone disease in this Chinese population.

  4. Cholesterol loading reduces SREBP-1 (show SREBF1 Proteins) mRNA expression in addition to reducing functional SREBP-1 (show SREBF1 Proteins) protein, and results in decreasing CYP8B1 gene transcription.

  5. Studies indicate a homogenous pattern for CYP8B1 expression in human liver, which was even rather than zonal.

  6. T(3) dose-dependently decreased total bile acid formation in parallel with decreased expression of CYP7A1 (show CYP7A1 Proteins) and CYP8B1

  7. Isoflavone-related induction of 12-alpha-hydroxylase (CYP8B1) was studied in vitro and murine in vivo models.

Mouse (Murine) Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 (CYP8B1) interaction partners

  1. Absence of Cyp8b1 results in improved glucose tolerance, insulin (show INS Proteins) sensitivity, and beta-cell function, mediated by absence of cholic acid in Cyp8b1(-/-) mice.

  2. Cholesterol lowering properties of oats involve increased production of bile acids via the classic pathway with up-regulation of CYP7A1 (show CYP7A1 Proteins) and CYP8B1.

  3. RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum and liver cholesterol levels.

  4. Feedback regulation of the rate-limiting biosynthetic enzyme CYP7A1 (show CYP7A1 Proteins) is lost in Cyp8b1(-/-) mice, causing expansion of the bile acid pool and alterations in cholesterol metabolism.

  5. In the intercross between C57BL/6J and CASA (show CSN1S1 Proteins)/Rk mice, Cyp8b1 is not responsible for biliary bile acid composition.

  6. The expression pattern of Cyp8b1 was studied in hepatocytes.

  7. Isoflavone-related induction of 12-alpha-hydroxylase (CYP8B1) was studied in vitro and murine in vivo models.

CYP8B1 Protein Profile

Protein Summary

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.

Gene names and symbols associated with CYP8B1

  • cytochrome P450, family 8, subfamily b, polypeptide 1 (Cyp8b1)
  • cytochrome P450, family 8, subfamily B, polypeptide 1 (cyp8b1)
  • cytochrome P450, family 8, subfamily B, polypeptide 1 (CYP8B1)
  • CP8B protein
  • CYP8B protein
  • CYP12 protein
  • MGC64456 protein

Protein level used designations for CYP8B1

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase , cytochrome P450 8b1 sterol 12 alpha-hydrolase , cytochrome P450, 8b1, sterol 12 alpha-hydrolase , cytochrome P450, family 8, subfamily B, polypeptide 1 , cytochrome P450, family 8, subfamily B , 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase , 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase , CYPVIIIB1 , cytochrome P450 8B1 , cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1 , sterol 12-alpha-hydroxylase , sterol 12-alpha-hydrolase , sterol 12-alpha hydroxylase

GENE ID SPECIES
81924 Rattus norvegicus
379482 Xenopus laevis
425055 Gallus gallus
538964 Bos taurus
1582 Homo sapiens
13124 Mus musculus
100009301 Oryctolagus cuniculus
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