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anti-Cytohesin 2 (CYTH2) Antibodies

The protein encoded by CYTH2 is a member of the PSCD family. Additionally we are shipping Cytohesin 2 Proteins (9) and Cytohesin 2 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYTH2 9266 Q99418
CYTH2 116692 P63035
CYTH2 19158 P63034
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Top anti-Cytohesin 2 Antibodies at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PSCD2 Antibody (N-term) in mouse kidney tissu... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB ABIN238611 (0.5µg/ml) staining of Human Brain (Cerebellum) lysate (35µ... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Rabbit Un-conjugated WB PSCD2 Antibody (N-term) (ABIN656173) western blot analysis in mouse ki... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to CYTH2 on formalin-fixed par... Immunofluorescence of monoclonal antibody to CYTH2 on HeLa cell. [anti... 100 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated IF Immunofluorescence of monoclonal antibody to PSCD2 on HeLa cell  (anti... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, ELISA, WB 100 μg Log in to see 8 to 10 Days
$537.17
Details
Mouse Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IF, IP, WB Immunoprecipitation of CYTH2 transfected lysate using anti-CYTH2 MaxPa... Western Blot analysis of CYTH2 expression in transfected 293T cell lin... 100 μL Log in to see 9 Days
$418.57
Details

CYTH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Rat (Rattus) , , , ,
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Mouse (Murine) , , , ,
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Top referenced anti-Cytohesin 2 Antibodies

  1. Human Polyclonal Cytohesin 2 Primary Antibody for EIA, WB - ABIN951803 : Merkulova, Bakulina, Thaker, Grüber, Marshansky: Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO. in Biochimica et biophysica acta 2010 (PubMed)
    Show all 5 references for ABIN951803

  2. Dog (Canine) Polyclonal Cytohesin 2 Primary Antibody for WB - ABIN374897 : Kolanus: Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transduction. in Immunological reviews 2007 (PubMed)

  3. Human Monoclonal Cytohesin 2 Primary Antibody for IF, IHC (p) - ABIN564002 : Mannell, Pircher, Chaudhry, Alig, Koch, Mettler, Pohl, Krötz: ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression. in Cardiovascular research 2011 (PubMed)

More Antibodies against Cytohesin 2 Interaction Partners

Human Cytohesin 2 (CYTH2) interaction partners

  1. Data establish a role for cytohesin-2/ARNO as a regulator of R-Ras and integrin recycling and suggest that ARF (show CDKN2A Antibodies)-regulated trafficking of R-Ras is required for R-Ras-dependent effects on spreading and adhesion formation.

  2. The authors show that Shigella flexneri IpgD phosphatase activity is required for recruitment of the ARF6 (show ARF6 Antibodies) guanine nucleotide exchange factor (show RASGRF1 Antibodies) (GEF (show SLC2A4RG Antibodies)) ARF nucleotide binding site opener (ARNO) to bacterial entry sites.

  3. inhibiting cytohesins or ARNO as cytoplasmic activators of EGFR (show EGFR Antibodies) and IGF-I (show IGF1 Antibodies) in colorectal cancer resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth in vivo and in vitro.

  4. Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 (show ARF6 Antibodies) in a GTP (show AK3 Antibodies)-bound state

  5. Expression of CYTH2 mutant deficient of the EFh2 domain in cells also inhibits Arf6 (show ARF6 Antibodies) activation and neurite extension.

  6. Phosphorylation of Ser392 of ARNO stabilized the C-terminal alpha-helix via formation of salt bridges between phospho-Ser392 and Arg390, Lys395, and Lys396.

  7. There is an association between cytohesin-2 expression and overall survival and disease-free survival in patients with hepatocellular carcinoma.

  8. Arf6 (show ARF6 Antibodies)/ ARNO signaling mediates phospholipase-D (show PLD Antibodies), ERK1/2 (show MAPK1/3 Antibodies) and cofilin (show CFL1 Antibodies) activation in pancreatic beta-cells.

  9. Kinetics of interaction between ADP-ribosylation factor-1 (Arf1 (show ARF1 Antibodies)) and the Sec7 (show CYTH1 Antibodies) domain of Arno guanine nucleotide exchange factor (show RASGRF1 Antibodies), modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A

  10. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (show ATP6V1B2 Antibodies) (V-ATPase (show DNAH8 Antibodies)) and cytohesin-2

Mouse (Murine) Cytohesin 2 (CYTH2) interaction partners

  1. The RLIP76 (show RALBP1 Antibodies)/R-Ras/ARNO complex localizes to recycling endosomes.

  2. signaling through cytohesin-2 is required for myelination by Schwann cells, and cytohesin-2 is added to the list of molecules known to underlie PNS myelination

  3. results together suggest that cytohesin 2 activates ARF6 (show ARF6 Antibodies) in a PI3K dependent manner and then the active ARF6 (show ARF6 Antibodies) causes phosphorylation of ERK1/2 (show MAPK1/3 Antibodies) during preadipocyte migration.

  4. Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 (show ARF6 Antibodies) in a GTP (show AK3 Antibodies)-bound state

  5. Expression of CYTH2 mutant deficient of the EFh2 domain in cells also inhibits Arf6 (show ARF6 Antibodies) activation and neurite extension.

  6. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (show ATP6V1B2 Antibodies) (V-ATPase (show DNAH8 Antibodies)) and cytohesin-2

  7. role for endothelial ARNO in VEGF (show VEGFA Antibodies)-dependent initiation of angiogenesis by regulation of VEGFR-2 (show KDR Antibodies) internalization in endothelial cells, resulting in the activation of the Akt (show AKT1 Antibodies) pathway, vessel permeability, and ultimately endothelial proliferation

  8. cytohesin-2, through a previously unexplored complex formation with paxillin (show PXN Antibodies), regulates preadipocyte migration; paxillin (show PXN Antibodies) plays a previously unknown role as a scaffold protein (show HOMER1 Antibodies) of Arf (show CDKN2A Antibodies) guanine-nucleotide exchange factor (show ARHGEF12 Antibodies)

  9. Specific motifs of the V-ATPase a2 (show ATP6V0A2 Antibodies)-subunit isoform interact with catalytic and regulatory domains of ARNO.

  10. Arl4D (show ARL4D Antibodies) is a previously unknown regulator of neurite formation through cytohesin-2 and Arf6 (show ARF6 Antibodies), providing another example that the functional interaction of two different small GTPases controls an important cellular function.

Cytohesin 2 (CYTH2) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Cytohesin 2 (CYTH2) Antibodies

  • cytohesin-2 (PTRG_08834) antibody
  • cytohesin 2 (cyth2) antibody
  • cytohesin 2 (CYTH2) antibody
  • pleckstrin homology, Sec7 and coiled-coil domains 2 (pscd2) antibody
  • cytohesin 2 (Cyth2) antibody
  • Arno antibody
  • CLM2 antibody
  • CTS18 antibody
  • CTS18.1 antibody
  • CYTH2 antibody
  • MGC80440 antibody
  • MGC84366 antibody
  • Pscd2 antibody
  • PSCD2L antibody
  • Sec7 antibody
  • Sec7B antibody
  • SEC7L antibody
  • Sec7p-L antibody
  • Sec7p-like antibody

Protein level used designations for anti-Cytohesin 2 (CYTH2) Antibodies

cytohesin-2 , cytohesin 2 , pleckstrin homology, Sec7 and coiled/coil domains 2 , pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) , cytohesin-2-like , ARF exchange factor , ARF nucleotide-binding site opener , PH, SEC7 and coiled-coil domain-containing protein 2 , pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2) , ARF nucleotide binding site opener , CLM2 , SEC7 homolog B , pleckstrin homology, Sec7 and coiled-coil domains 2 , mSec7-2

GENE ID SPECIES
6347120 Pyrenophora tritici-repentis Pt-1C-BFP
444689 Xenopus laevis
448569 Xenopus (Silurana) tropicalis
718682 Macaca mulatta
746757 Pan troglodytes
779436 Xenopus laevis
100216436 Ovis aries
100387102 Callithrix jacchus
100440057 Pongo abelii
9266 Homo sapiens
116692 Rattus norvegicus
19158 Mus musculus
476423 Canis lupus familiaris
768035 Bos taurus
100240721 Sus scrofa
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