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Cytohesin 2 Proteins (CYTH2)

The protein encoded by CYTH2 is a member of the PSCD family. Additionally we are shipping Cytohesin 2 Antibodies (85) and Cytohesin 2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYTH2 9266 Q99418
CYTH2 116692 P63035
CYTH2 19158 P63034
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Top Cytohesin 2 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,107.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,138.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CYTH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced Cytohesin 2 Proteins

  1. Human Cytohesin 2 Protein expressed in Escherichia coli (E. coli) - ABIN1098416 : Chardin, Paris, Antonny, Robineau, Béraud-Dufour, Jackson, Chabre: A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. in Nature 1997 (PubMed)
    Show all 2 references for ABIN1098416

More Proteins for Cytohesin 2 (CYTH2) Interaction Partners

Human Cytohesin 2 (CYTH2) interaction partners

  1. Data establish a role for cytohesin-2/ARNO as a regulator of R-Ras and integrin recycling and suggest that ARF-regulated trafficking of R-Ras is required for R-Ras-dependent effects on spreading and adhesion formation.

  2. The authors show that Shigella flexneri IpgD phosphatase activity is required for recruitment of the ARF6 (show ARF6 Proteins) guanine nucleotide exchange factor (show RASGRF1 Proteins) (GEF (show SLC2A4RG Proteins)) ARF nucleotide binding site opener (ARNO) to bacterial entry sites.

  3. inhibiting cytohesins or ARNO as cytoplasmic activators of EGFR (show EGFR Proteins) and IGF-I (show IGF1 Proteins) in colorectal cancer resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth in vivo and in vitro.

  4. Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 (show ARF6 Proteins) in a GTP (show AK3 Proteins)-bound state

  5. Expression of CYTH2 mutant deficient of the EFh2 domain in cells also inhibits Arf6 (show ARF6 Proteins) activation and neurite extension.

  6. Phosphorylation of Ser392 of ARNO stabilized the C-terminal alpha-helix via formation of salt bridges between phospho-Ser392 and Arg390, Lys395, and Lys396.

  7. There is an association between cytohesin-2 expression and overall survival and disease-free survival in patients with hepatocellular carcinoma.

  8. Arf6 (show ARF6 Proteins)/ ARNO signaling mediates phospholipase-D, ERK1/2 and cofilin (show CFL1 Proteins) activation in pancreatic beta-cells.

  9. Kinetics of interaction between ADP-ribosylation factor-1 (Arf1 (show ARF1 Proteins)) and the Sec7 (show CYTH1 Proteins) domain of Arno guanine nucleotide exchange factor (show RASGRF1 Proteins), modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A

  10. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2

Mouse (Murine) Cytohesin 2 (CYTH2) interaction partners

  1. The RLIP76 (show RALBP1 Proteins)/R-Ras/ARNO complex localizes to recycling endosomes.

  2. signaling through cytohesin-2 is required for myelination by Schwann cells, and cytohesin-2 is added to the list of molecules known to underlie PNS myelination

  3. results together suggest that cytohesin 2 activates ARF6 in a PI3K dependent manner and then the active ARF6 causes phosphorylation of ERK1/2 during preadipocyte migration.

  4. Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 (show ARF6 Proteins) in a GTP (show AK3 Proteins)-bound state

  5. Expression of CYTH2 mutant deficient of the EFh2 domain in cells also inhibits Arf6 (show ARF6 Proteins) activation and neurite extension.

  6. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2

  7. role for endothelial ARNO in VEGF (show VEGFA Proteins)-dependent initiation of angiogenesis by regulation of VEGFR-2 (show KDR Proteins) internalization in endothelial cells, resulting in the activation of the Akt (show AKT1 Proteins) pathway, vessel permeability, and ultimately endothelial proliferation

  8. cytohesin-2, through a previously unexplored complex formation with paxillin (show PXN Proteins), regulates preadipocyte migration; paxillin (show PXN Proteins) plays a previously unknown role as a scaffold protein (show HOMER1 Proteins) of Arf guanine-nucleotide exchange factor (show ARHGEF12 Proteins)

  9. Specific motifs of the V-ATPase a2 (show ATP6V0A2 Proteins)-subunit isoform interact with catalytic and regulatory domains of ARNO.

  10. Arl4D (show ARL4D Proteins) is a previously unknown regulator of neurite formation through cytohesin-2 and Arf6 (show ARF6 Proteins), providing another example that the functional interaction of two different small GTPases controls an important cellular function.

Cytohesin 2 (CYTH2) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Cytohesin 2 Proteins (CYTH2)

  • cytohesin-2 (PTRG_08834)
  • cytohesin 2 (cyth2)
  • cytohesin 2 (CYTH2)
  • pleckstrin homology, Sec7 and coiled-coil domains 2 (pscd2)
  • cytohesin 2 (Cyth2)
  • Arno protein
  • CLM2 protein
  • CTS18 protein
  • CTS18.1 protein
  • CYTH2 protein
  • MGC80440 protein
  • MGC84366 protein
  • Pscd2 protein
  • PSCD2L protein
  • Sec7 protein
  • Sec7B protein
  • SEC7L protein
  • Sec7p-L protein
  • Sec7p-like protein

Protein level used designations for Cytohesin 2 Proteins (CYTH2)

cytohesin-2 , cytohesin 2 , pleckstrin homology, Sec7 and coiled/coil domains 2 , pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) , cytohesin-2-like , ARF exchange factor , ARF nucleotide-binding site opener , PH, SEC7 and coiled-coil domain-containing protein 2 , pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2) , ARF nucleotide binding site opener , CLM2 , SEC7 homolog B , pleckstrin homology, Sec7 and coiled-coil domains 2 , mSec7-2

GENE ID SPECIES
6347120 Pyrenophora tritici-repentis Pt-1C-BFP
444689 Xenopus laevis
448569 Xenopus (Silurana) tropicalis
718682 Macaca mulatta
746757 Pan troglodytes
779436 Xenopus laevis
100216436 Ovis aries
100387102 Callithrix jacchus
100440057 Pongo abelii
9266 Homo sapiens
116692 Rattus norvegicus
19158 Mus musculus
476423 Canis lupus familiaris
768035 Bos taurus
100240721 Sus scrofa
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