Cytokine Receptor-Like Factor 2 Proteins (CRLF2)

The protein encoded by CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP). Additionally we are shipping CRLF2 Antibodies (115) and CRLF2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CRLF2 64109 Q9HC73
CRLF2 57914 Q8CII9
CRLF2 171499  
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Top CRLF2 Proteins at

Showing 9 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Mammalian Cells Mouse Fc Tag   50 μg Log in to see 4 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Human Mouse His tag   10 μg Log in to see 15 to 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days

CRLF2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) , ,
, ,
Rat (Rattus)

Top referenced CRLF2 Proteins

  1. Human CRLF2 Protein expressed in Escherichia coli (E. coli) - ABIN1098797 : Chen, Harvey, Mullighan, Gastier-Foster, Wharton, Kang, Borowitz, Camitta, Carroll, Devidas, Pullen, Payne-Turner, Tasian, Reshmi, Cottrell, Reaman, Bowman, Carroll, Loh, Winick, Hunger, Willman: Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study. in Blood 2012 (PubMed)
    Show all 2 references for 1098797

More Proteins for Cytokine Receptor-Like Factor 2 (CRLF2) Interaction Partners

Human Cytokine Receptor-Like Factor 2 (CRLF2) interaction partners

  1. CRLF2 overexpression is associated with childhood B-cell acute lymphoblastic leukemia.

  2. CRLF2 gene rearrangement is associated with acute lymphoblastic leukemia.

  3. TSLPR levels were found to be significantly higher in asthmatic than in nonasthmatic children. TSLPR expression in non-allergic asthmatic and allergic asthmatic groups was found to be significantly higher than in non-allergic nonasthmatic group

  4. In adult B-cell acute lymphoblastic leukemia without recurrent fusion genes , high CRLF2 expression is associated with distinct clinico-biological features and an unfavourable prognosis

  5. CD4 (show CD4 Proteins)+ T cells from atopic dermatitis patients directly interacted with TSLP (show TSLP Proteins) to produce a higher amount of IL-4 (show IL4 Proteins) than those from normal subjects, and this action was attenuated with anti-TSLPR antibody

  6. The levels of mRNA for TSLP (show TSLP Proteins) and TSLPR were significantly elevated in parotid gland tissues from the KD group as compared to the control group.

  7. Differences exist in the genetic profiles of Down syndrome-associated acute lymphoblastic leukemia patients in Japan and in Western countries, and that P2RY8 (show P2RY8 Proteins)-CRLF2 and EBF1 (show EBF1 Proteins) deletions may cooperate in leukemogenesis in a subset of Japanese DS-ALL patients.

  8. CRLF2 overexpression (OE) was detected in 30 (18%) of 167 patients, the P2RY8-CRLF2 fusion was identified in only 3 (1.8%) of 167 patients, all of which demonstrated CRLF2 OE.

  9. we report noncysteine in-frame mutations in IL7R (show IL7R Proteins) and CRLF2 located in a region of the transmembrane domain closer to the cytosolic domain in acute lymphoblastic leukemias

  10. The TSLPR in blood plateltes promotes platelet activation via activating the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.

Mouse (Murine) Cytokine Receptor-Like Factor 2 (CRLF2) interaction partners

  1. A novel mouse xenograft model to study the role of TSLP (show TSLP Proteins)-induced CRLF2 (show CRLF3 Proteins) signals in normal and malignant human B lymphopoiesis has been developed.

  2. High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt (show AKT1 Proteins) signal pathway.

  3. Activating thymic stromal lymphopoietin (show TSLP Proteins) promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model.

  4. Suggest that Treg defects in ApoE (show APOE Proteins)(-/-) mice might partially be attributed to the disruption of TSLP (show TSLP Proteins)-TSLPR-LAP signaling in epithelial cells and dendritic cells.

  5. The structure of the mouse TSLP (show TSLP Proteins)-mediated signaling complex reveals how TSLP (show TSLP Proteins) establishes extensive interfaces with its cognate receptor (TSLPR).

  6. TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.

  7. A previously unrecognized role was found for TSLP (show TSLP Proteins)/TSLPR signaling in type 2 immunity as an important enhancer for the development of alternately activated macrophages as well as for chemokine (show CCL1 Proteins) production.

  8. mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization.

  9. Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice.

  10. Presence of functional TSLP (show TSLP Proteins)-specific receptor chain is required for the development of T helper cell type (Th)2 contact hypersensitivity to the hapten fluorescein isothiocyanate (FITC).

CRLF2 Protein Profile

Protein Summary

The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CRLF2

  • cytokine receptor-like factor 2 (CRLF2)
  • cytokine receptor-like factor 2-like (LOC529792)
  • cytokine receptor-like factor 2 (Crlf2)
  • Crl2 protein
  • CRLF2 protein
  • CRLF2Y protein
  • CRLM2 protein
  • Ly114 protein
  • Tpte2 protein
  • Tslpr protein

Protein level used designations for CRLF2

cytokine receptor-like factor 2 , IL-XR , P2RY8/CRLF2 fusion , TSLP receptor , cytokine receptor CRL2 precusor , cytokine receptor-like 2 , thymic stromal lymphopoietin protein receptor , thymic stromal lymphopoietin receptor , thymic stromal-derived lymphopoietin receptor , CRLM-2 , cytokine receptor-like molecule 2 , delta 1 , lymphocyte antigen 114 , thymic stromal-derived lymphopoietin, receptor , transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 , type I cytokine receptor delta 1

491709 Canis lupus familiaris
529792 Bos taurus
749758 Pan troglodytes
100582238 Nomascus leucogenys
64109 Homo sapiens
57914 Mus musculus
171499 Rattus norvegicus
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