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Cytoplasmic FMR1 Interacting Protein 1 Proteins (CYFIP1)

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. Additionally we are shipping CYFIP1 Antibodies (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYFIP1 23191 Q7L576
CYFIP1 20430 Q7TMB8
Rat CYFIP1 CYFIP1 308666  
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Top CYFIP1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days

CYFIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1) Interaction Partners

Human Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1) interaction partners

  1. Reduced CYFIP1 in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks.

  2. Hippocampal synapses with reduced Cyfip1 are larger and release neurotransmitter more rapidly.

  3. Data confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time

  4. This study confirmed that CYFIP2 (show CYFIP2 Proteins) were altered in postsynaptic density in patient with schizophrenia.

  5. An imbalance of specific isoforms of CYFIP1, an FMRP (show FMR1 Proteins) interaction partner, and CAMK4 (show CAMK4 Proteins), a transcriptional regulator of the FMRP (show FMR1 Proteins) gene, modulates risk for autism spectrum disorders.

  6. Protein complexes containing CYFIP/Sra (show SRA1 Proteins)/PIR121 (show CYFIP2 Proteins) coordinate Arf1 (show ARF1 Proteins) and Rac1 signalling during clathrin-AP-1 (show FOSB Proteins)-coated carrier biogenesis at the trans-golgi network.

  7. CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation

  8. quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 (show TUBGCP5 Proteins) in Prader-Willi syndrome and correlated levels with psychological and behavior scales

  9. Study found that Cyfip1, a subunit of the WAVE complex, which regulates cytoskeletal dynamics, is commonly deleted in human epithelial cancers.

Mouse (Murine) Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1) interaction partners

  1. In Cyfip1-deficient mice, parental origin determines the impairment of synaptic functions and behavior.

  2. Data suggest that MAP kinase (show MAPK1 Proteins)-interacting kinases (Mnk1 (show MKNK1 Proteins), Mnk2 (show MKNK2 Proteins)) regulate cell migration/wound healing, expression of vimentin (show VIM Proteins), stability of vimentin (show VIM Proteins) protein, and binding of cytoplasmic eIF4E (eukaryotic translation initiation factor 4E (show EIF4E Proteins)) and Cyfip1.

  3. CYFIP2 (show CYFIP2 Proteins) is a key regulator of cocaine response in mammals and present a framework to use mouse substrains to identify previously unknown genes and alleles regulating behavior.

  4. This study demonistrated that CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.

  5. haploinsufficiency of Cyfip1 mimics key aspects of the phenotype of Fmr1 (show FMR1 Proteins) knockout mice and are consistent with the hypothesis that these effects are mediated by interaction of Cyfip1 and Fmrp (show FMR1 Proteins) in regulating activity-dependent translation.

  6. Sra-1 and Nap1 are constitutive and essential components of a WAVE2- and Abi-1-containing complex linking Rac to site-directed actin assembly.

  7. The translational repression activity of FMRP (show FMR1 Proteins) in the brain is mediated, at least in part, by CYFIP1.

CYFIP1 Protein Profile

Protein Summary

Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.

Gene names and symbols associated with CYFIP1

  • cytoplasmic FMR1 interacting protein 1 (CYFIP1)
  • cytoplasmic FMR1 interacting protein 1 (cyfip1)
  • cytoplasmic FMR1 interacting protein 1 (Cyfip1)
  • CY protein
  • CYFIP protein
  • E030028J09Rik protein
  • fb15a06 protein
  • l(7)1Rl protein
  • l7Rl1 protein
  • l71Rl protein
  • mKIAA0068 protein
  • P140SRA-1 protein
  • P140sra1 protein
  • pl-1 protein
  • Shyc protein
  • Sra-1 protein
  • Sra1 protein
  • TUBGCP5 protein
  • wu:fb15a06 protein

Protein level used designations for CYFIP1

cytoplasmic FMR1 interacting protein 1 , cytoplasmic FMR1-interacting protein 1 , cytoplasmic FMRP interacting protein 1 , selective hybridizing clone , specifically Rac1-associated protein 1 , sra-1 , cytoplasmic FMR1-interacting protein 1 homolog

418677 Gallus gallus
453278 Pan troglodytes
586128 Strongylocentrotus purpuratus
719579 Macaca mulatta
100411412 Callithrix jacchus
100459206 Pongo abelii
100564778 Anolis carolinensis
23191 Homo sapiens
479001 Canis lupus familiaris
100141021 Bos taurus
20430 Mus musculus
308666 Rattus norvegicus
336613 Danio rerio
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