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Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. Additionally we are shipping CYFIP1 Antibodies (24) and CYFIP1 Kits (3) and many more products for this protein.
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The studies suggest that MNK (show ATP7A Proteins)-eiF4E (show EIF4E Proteins) axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1. (Review)
rs4778298, a common variant at CYFIP1 is associated with inter-individual variation in surface area across the left supramarginal gyrus.
we show that stapled peptides targeting the interface between NCKAP1 (show NCKAP1 Proteins) and CYFIP1 destabilize the WASF3 (show WASF3 Proteins) complex... thereby suppressing invasion and metastasis of breast cancer cells.
Both mRNA and protein expression levels of Cyfip1 were significantly lower in ALL patients.
Reduced CYFIP1 in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks.
Hippocampal synapses with reduced Cyfip1 are larger and release neurotransmitter more rapidly.
Data confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time
This study confirmed that CYFIP2 (show CYFIP2 Proteins) were altered in postsynaptic density in patient with schizophrenia.
An imbalance of specific isoforms of CYFIP1, an FMRP (show FMR1 Proteins) interaction partner, and CAMK4 (show CAMK4 Proteins), a transcriptional regulator of the FMRP (show FMR1 Proteins) gene, modulates risk for autism spectrum disorders.
Protein complexes containing CYFIP/Sra (show SRA1 Proteins)/PIR121 (show CYFIP2 Proteins) coordinate Arf1 (show ARF1 Proteins) and Rac1 signalling during clathrin-AP-1 (show FOSB Proteins)-coated carrier biogenesis at the trans-golgi network.
In Cyfip1-deficient mice, parental origin determines the impairment of synaptic functions and behavior.
Data suggest that MAP kinase (show MAPK1 Proteins)-interacting kinases (Mnk1 (show MKNK1 Proteins), Mnk2 (show MKNK2 Proteins)) regulate cell migration/wound healing, expression of vimentin (show VIM Proteins), stability of vimentin (show VIM Proteins) protein, and binding of cytoplasmic eIF4E (eukaryotic translation initiation factor 4E (show EIF4E Proteins)) and Cyfip1.
CYFIP2 (show CYFIP2 Proteins) is a key regulator of cocaine response in mammals and present a framework to use mouse substrains to identify previously unknown genes and alleles regulating behavior.
This study demonistrated that CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.
haploinsufficiency of Cyfip1 mimics key aspects of the phenotype of Fmr1 (show FMR1 Proteins) knockout mice and are consistent with the hypothesis that these effects are mediated by interaction of Cyfip1 and Fmrp (show FMR1 Proteins) in regulating activity-dependent translation.
Sra-1 and Nap1 are constitutive and essential components of a WAVE2- and Abi-1-containing complex linking Rac to site-directed actin assembly.
The translational repression activity of FMRP (show FMR1 Proteins) in the brain is mediated, at least in part, by CYFIP1.
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
cytoplasmic FMR1 interacting protein 1
, cytoplasmic FMR1-interacting protein 1
, cytoplasmic FMRP interacting protein 1
, selective hybridizing clone
, specifically Rac1-associated protein 1
, cytoplasmic FMR1-interacting protein 1 homolog