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Inhibits differentiation of intermediate mesoderm from an early stage to inhibit pronephric differentiation but induce neural differentiation. Additionally we are shipping CPEB3 Antibodies (39) and CPEB3 Proteins (3) and many more products for this protein.
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Data suggest that the RNA recognition motif (RRM) domain of CPEB3 (as a soluble peptide fragment) exhibits protein conformation distinct from those of the canonical RRM domain.
cleavage of CPEB3 by NMDA-activated calpain 2 (show CAPN2 ELISA Kits) accounts for the activity-related translation of CPEB3-targeted RNAs
Together, these results indicate that Tob (show TDO2 ELISA Kits) mediates the recruitment of Caf1 (show CHAF1B ELISA Kits) to the target of CPEB3 and elicits deadenylation and decay of the mRNA.
Secondary structure determination and native gel analyses reveal that the cleaved population of the CPEB3 ribozyme has a single, secondary structure that closely resembles the HDV ribozyme
isolation of a ribozyme conserved mammalian sequence that resides in an intron of the CPEB3 gene
CPEB3-regulated translation of TRPV1 (show TRPV1 ELISA Kits) RNA may play a role in fine-tuning thermal sensitivity of nociceptors.
CPEB3 is SUMOylated in hippocampal neurons. CPEB3 regulates SUMO-2 (show SUMO2 ELISA Kits) translation.
CPEB3 interacts with the actin cytoskeleton in yeast and at mouse synapses. CPEB3 is a functional prion (show PRNP ELISA Kits) with a tripartite prion (show PRNP ELISA Kits) domain architecture.
The main finding of our study is that CPEB3-mediated protein synthesis is required for long-term hippocampal-based memory storage.
Cpeb3 null mice exhibited enhanced short-term fear memory and translationally elevated PSD95 (show DLG4 ELISA Kits), NMDA receptors and GluA1 (show GRIA1 ELISA Kits).
These results suggest a model whereby Neuralized1-dependent ubiquitination facilitates hippocampal plasticity and hippocampal-dependent memory storage by modulating the activity of CPEB3 and CPEB3-dependent protein synthesis and synapse formation.
CPEB3 has a novel function in the nucleus as to suppress Stat5b (show STAT5B ELISA Kits)-dependent EGFR (show EGFR ELISA Kits) gene transcription
show that CPEB3 expression is increased in a time-dependent manner during the course of postnatal development, and CPEB3 is localized mostly in the inner retina, including retinal ganglion cells.
CPEB3 is expressed in the principal cell layers of the hippocampus
Inhibits differentiation of intermediate mesoderm from an early stage to inhibit pronephric differentiation but induce neural differentiation.
cytoplasmic polyadenylation element-binding protein 3
, CPE-binding protein 3
, cytoplasmic polyadenylation element binding protein 3
, cytoplasmatic polyadenylation element binding protein 3