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CKAP2 is a cytoskeleton-associated protein involved in mitotic progression (Seki and Fang, 2007 [PubMed 17376772]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Cytoskeleton Associated Protein 2 Antibodies (27) and many more products for this protein.
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Chromatin CKAP2 is an independent prognostic marker for relapse-free survival in early-stage breast cancer, and could potentially replace the mitotic activity index in clinical evaluation of proliferation activity.
The transcriptional activity of RHOA (show RHOA Proteins), SEMA3B (show SEMA3B Proteins), and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors.
CKAP2 is involved in the maintenance of microtubule nucleation sites
GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1 (show PSG1 Proteins), possibly by Cyclin A (show CCNA2 Proteins)/Cdk (show CDK4 Proteins) complex.
Findings suggest that the motif surrounding Ser627 ((625) RRSRRL (630)) is a critical for kinase-substrate recognition and for regulation of the subcellular localization of TMAP during mitosis.
TMAP is limited to pre-anaphase stages and suggest that the multiple phosphorylation may not act in concert but serve diverse functions.
CKAP2 comprises nine exons ranging 70-1442 bp and is about 22 kb in size (regulatory regions included). The CKAP2 promoter contains CCAAT (-39...-33) rather than the canonical TATA box, and harbors nine binding sites for six transcription factors
Data show that degradation of TMAP/CKAP2 during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 (show CDH1 Proteins) and that the KEN box motif near the N terminus is necessary for its destruction.
CKAP2 is a physiological substrate of anaphase-promoting complex (show CDC26 Proteins)/cyclosome during mitotic exit and that a tight regulation of the CKAP2 protein level is critical for the normal mitotic progression.
Cdk1 (show CDK1 Proteins)-cyclin B1 (show CCNB1 Proteins)-mediated phosphorylation of TMAP is important for and contributes to proper regulation of microtubule dynamics and establishment of functional bipolar spindles during mitosis
These findings suggest that CKAP2 is a new MAP with microtubule-stabilizing properties
Data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy.
The cellular functions of TMAP/CKAP2 might be regulated by timely phosphorylation and dephosphorylation during the course of mitosis.
Our present findings demonstrate that TMAP/CKAP2 is essential for proper chromosome segregation and for maintaining genomic stability.
CKAP2 is a cytoskeleton-associated protein involved in mitotic progression (Seki and Fang, 2007
cytoskeleton-associated protein 2
, intracellular protein
, cytoskeleton associated protein 2
, cytoskeleton-associated protein 2-like
, CTCL tumor antigen se20-10
, tumor- and microtubule-associated protein
, tumor-associated microtubule-associated protein