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Cytotoxic T-Lymphocyte-Associated Protein 4 Proteins (CTLA4)

CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. Additionally we are shipping CTLA4 Antibodies (441) and CTLA4 Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTLA4 12477 P09793
CTLA4 1493 P16410
CTLA4 63835  
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Top CTLA4 Proteins at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag Human CTLA-4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human B7-2, Fc Tag  with a linear range of 1-6.4 ng/mL. 100 μg Log in to see 2 to 3 Days
$121.00
Details
HOST_HEK-293 Cells Cynomolgus AVI tag,His tag,Biotin Biotinylated Cynomolgus CTLA-4 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 200 μg Log in to see 11 Days
$1,518.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_CHO Cells Human Fc Tag   10 μg Log in to see 10 to 12 Days
$81.53
Details
HOST_CHO Cells Human Un-conjugated 4 pack Log in to see 10 to 12 Days
$86.96
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_CHO Cells Mouse Fc Tag   10 μg Log in to see 10 to 12 Days
$81.53
Details

CTLA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , , , ,
, , , ,
Human , , , , , , , , , ,
, , , , , , , , , , , , ,
Rat (Rattus) , ,
, , ,

Top referenced CTLA4 Proteins

  1. Mouse (Murine) CTLA4 Protein expressed in CHO Cells - ABIN2666795 : Gerold, Zheng, Rainbow, Zernecke, Wicker, Kissler: The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function. in Diabetes 2011 (PubMed)
    Show all 7 references for ABIN2666795

  2. Human CTLA4 Protein expressed in CHO Cells - ABIN2666793 : Mittal, Chaturvedi, Rohlfsen, Gupta, Joshi, Hegde, Bociek, Joshi: Role of CTLA4 in the proliferation and survival of chronic lymphocytic leukemia. in PLoS ONE 2013 (PubMed)
    Show all 7 references for ABIN2666793

  3. Human CTLA4 Protein expressed in CHO Cells - ABIN2666967 : Lindsten, Lee, Harris, Petryniak, Craighead, Reynolds, Lombard, Freeman, Nadler, Gray: Characterization of CTLA-4 structure and expression on human T cells. in Journal of immunology (Baltimore, Md. : 1950) 1993 (PubMed)
    Show all 3 references for ABIN2666967

  4. Human CTLA4 Protein expressed in HEK-293 Cells - ABIN2487344 : Ross, Robinson, Amato, McMillan, Westcott, Wolf, Robinson: Therapeutic monoclonal antibodies in human breast milk: a case study. in Melanoma research 2014 (PubMed)
    Show all 2 references for ABIN2487344

  5. Human CTLA4 Protein expressed in Escherichia coli (E. coli) - ABIN1098772 : Rudd, Taylor, Schneider: CD28 and CTLA-4 coreceptor expression and signal transduction. in Immunological reviews 2009 (PubMed)
    Show all 2 references for ABIN1098772

  6. Cynomolgus CTLA4 Protein expressed in HEK-293 Cells - ABIN2180929 : Magistrelli, Jeannin, Herbault, Benoit De Coignac, Gauchat, Bonnefoy, Delneste: A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells. in European journal of immunology 1999 (PubMed)

More Proteins for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Interaction Partners

Mouse (Murine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Data suggest enhanced clinical benefit from combining CTLA-4 antigen blockade with poxvirus-based active immunotherapy.

  2. up-regulated expression correlates with the tolerogenic effect of syngeneic hematopoietic stem cell transplantation

  3. Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner

  4. CTLA-4 has a regulatory T cell-intrinsic role in limiting peripheral regulatory T cell expansion and activation, and in their capacity to control conventional T cells.

  5. The Ctla4 SNP (e2_77A/G) does not alter diabetes susceptibility, but does control mRNA alternative splicing.

  6. Sorafenib suppressed the expression of immunosuppressive factors in MDSCs. These data indicate that combination therapy of sorafenib and anti-CTLA-4 Ab may be effective in advanced kidney cancer patients.

  7. The co-stimulatory molecule CTLA-4 mediates in vitro differentiation of iTreg cells.

  8. The bullseye immunological synapse formation is mediated by CTLA4, and may negatively control T-cell activation as a suppressive synapse.

  9. this study reports that regulatory T (Treg) cells orchestrate memory T cell quiescence by suppressing effector and proliferation programs through inhibitory receptor, cytotoxic- T-lymphocyte-associated protein-4 (CTLA-4).

  10. Short-term blockade with anti-CTLA-4 antibody in wild-type mice is sufficient to elicit follicular helper T cell generation and germinal center development. The latter occurs in a CD28 (show CD28 Proteins)-dependent manner.

Human Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. This study showed that CTLA-4 affects the expression of the key regulators of G1 phase progression in chronic lymphocytic leukaemia cells as well as in normal B lymphocytes.

  2. There is an association between systemic inflammatory markers, oxidative stress and the cytotoxic T lymphocyte antigen-4 G-1661A GG+AG genotypes, malondialdehyde and neopterin which are the most conventional risk factors for coronary heart disease.

  3. genetic association studies in an Egyptian population: Data suggest an SNP in the promoter region of CTLA4 (rs5742909, -318C/T) is associated with rheumatoid arthritis in the population studied; severity of the disease does not appear to be associated with this SNP.

  4. It failed to show any association between CTLA-4 -318C/T polymorphism and the risk of malignant bone tumors.

  5. this study shows that CTLA-4 expression in the naive Treg is decreased in preterm newborns

  6. No significant association was found between +49A/G (rs231775), -318C/T (rs5742909), and +6230A/G (rs3087243) CTLA-4 gene polymorphisms and lymphoid malignancies.

  7. Studies suggest that the cytotoxic T lymphocyte associated protein 4 (CTLA4) polymorphisms of the three alleles are not associated with genetic susceptibility to non-Hodgkin's lymphoma (NHL) risk.

  8. Immune surveillance is an important mechanism in prevention of cancer development and inhibition of growth of tumors and metastasis. Checkpoint pathways prevent immune response through multiple methods including CTLA-4 and PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins) pathways.A variety of immune checkpoint inhibitors (PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins) and CTLA-4 inhibitors) have been studied in recurrent and metastatic head and neck cancers with encouraging efficacy

  9. n combination with anti-PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins), the CTLA-4-expanded T cells are prevented from being functionally inhibited when they enter into the tumor microenvironment.

  10. The CTLA-4 receptor was one of the first checkpoint inhibitors to be targeted with limited exploration and efficacy in sarcoma.The PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins) immunologic checkpoint pathway has demonstrated efficacy in many malignancies; studies are ongoing in sarcoma.

Pig (Porcine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Suggest a truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin as a novel approach for in vivo depletion of CD80 (show CD80 Proteins)-positive cells.

Cow (Bovine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. The surface expression of CTLA-4 was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 (show ZAP70 Proteins) were decreased in CD4 (show CD4 Proteins)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

  2. These results suggested that the expression level of CTLA-4 in CD4 (show CD4 Proteins)-positive T cells has a potentially immunosuppressive function in bovine leukemia infection.

  3. Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 (show FOXP3 Proteins) and CTLA4.

CTLA4 Protein Profile

Protein Summary

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Gene names and symbols associated with CTLA4

  • cytotoxic T-lymphocyte-associated protein 4 precursor (CTLA-4)
  • cytotoxic T-lymphocyte-associated protein 4 (CTLA4)
  • cytotoxic T-lymphocyte-associated protein 4 (LOC100222727)
  • cytotoxic T-lymphocyte-associated protein 4 (Ctla4)
  • CD protein
  • Cd152 protein
  • CELIAC3 protein
  • Ctla-4 protein
  • CTLA4 protein
  • GRD4 protein
  • GSE protein
  • IDDM12 protein
  • Ly-56 protein
  • sCTLA4 protein

Protein level used designations for CTLA4

cytotoxic T-lymphocyte-associated protein 4 precursor , CD152 protein , cytotoxic T-lymphocyte protein 4 , cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM , cytotoxic T-lymphocyte-associated protein 4 , costimulatory molecule B7 receptor , cytotoxic T lymphocyte-associated antigen 4 , CD152 antigen , cytotoxic T-lymphocyte-associated antigen 4 , CD152 isoform , celiac disease 3 , cytotoxic T lymphocyte associated antigen 4 short spliced form , cytotoxic T-lymphocyte antigen 4 , cytotoxic T-lymphocyte-associated serine esterase-4 , ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 , soluble form , transmembrane form , CTLA-4 , cytotoxic T lymphocyte-associated protein 4 , costimulatory molecule B7 receptor CD152

GENE ID SPECIES
443040 Ovis aries
705673 Macaca mulatta
100222727 Taeniopygia guttata
424106 Gallus gallus
470619 Pan troglodytes
493743 Felis catus
100126716 Papio anubis
12477 Mus musculus
1493 Homo sapiens
63835 Rattus norvegicus
100009412 Oryctolagus cuniculus
397286 Sus scrofa
403696 Canis lupus familiaris
281732 Bos taurus
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