Cytotoxic T-Lymphocyte-Associated Protein 4 Proteins (CTLA4)

CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. Additionally we are shipping CTLA4 Antibodies (453) and CTLA4 Kits (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CTLA4 12477 P09793
CTLA4 1493 P16410
CTLA4 63835  
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Top CTLA4 Proteins at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,649.05
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$714.00
Details
HEK-293 Cells Human His tag Human CTLA-4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human B7-2, Fc Tag  with a linear range of 1-6.4 ng/mL. 100 μg Log in to see 2 to 3 Days
$121.00
Details
HEK-293 Cells Cynomolgus AVI tag,Biotin,His tag Biotinylated Cynomolgus CTLA-4 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 200 μg Log in to see 11 Days
$1,518.00
Details
HEK-293 Cells Rat Fc Tag Immobilized Mouse B7-2, His Tag  with a linear range of 0.2-6 ng/mL. Rat CTLA-4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 5 Days
$275.00
Details
HEK-293 Cells Rabbit Fc Tag Rabbit CTLA-4 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 5 Days
$385.00
Details
HEK-293 Cells Human Fc Tag Human CTLA-4, mouse IgG2a Fc Tag, low endotoxin on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 5 Days
$319.00
Details
HEK-293 Cells Mouse Fc Tag Immobilized Mouse B7-1, Fc Tag  with a linear range of 0.1-3 ng/mL. Immobilized Mouse B7-2, Fc Tag  with a linear range of 0.4-3 ng/mL. 100 μg Log in to see 5 Days
$319.00
Details
HOST_HEK-293T Cells Human His-DYKDDDDK-Strep II Tag 2 μg Log in to see 11 to 12 Days
$614.87
Details

CTLA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , , , ,
, , , ,
Human , , , , , , , , ,
, , , , , , , , , , , , , , ,
Rat (Rattus) , ,
, , ,

Top referenced CTLA4 Proteins

  1. Human CTLA4 Protein expressed in HEK-293 Cells - ABIN2487344 : Ross, Robinson, Amato, McMillan, Westcott, Wolf, Robinson: Therapeutic monoclonal antibodies in human breast milk: a case study. in Melanoma research 2014 (PubMed)
    Show all 2 Pubmed References

More Proteins for Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Interaction Partners

Rhesus Monkey Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Data show that CTLA-4(+)PD-1 (show PDCD1 Proteins)(-) memory CD4 (show CD4 Proteins)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (show GUSB Proteins), and contained replication-competent and infectious virus.

Mouse (Murine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Tregs were observed to regulate CD4 (show CD4 Proteins)(+), but not CD8 (show CD8A Proteins)(+), T cell infiltration into tumors through a CTLA-4/CD80 (show CD80 Proteins) dependent mechanism. Disrupting CTLA-4 interaction with CD80 (show CD80 Proteins) was sufficient to induce CD4 (show CD4 Proteins) T cell infiltration into tumors.

  2. These results suggest that CD44 (show CD44 Proteins)(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 pathway.

  3. data suggest that increased expression of checkpoint blockade molecules PD-1 (show PDCD1 Proteins) and CTLA-4 on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients

  4. Treg cells expand in both humans and mice in blood-stage malaria and interfere with conventional T helper cell responses and follicular T helper (TFH)-B cell interactions in germinal centers. Mechanistically, Treg cells function in a critical temporal window to impede protective immunity through cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4).

  5. CTLA-4 expressed by FOXP3 (show FOXP3 Proteins)(+) regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.

  6. results are consistent with a complex pathway in which CD28 (show CD28 Proteins) is the primary driver of Treg proliferation and CTLA-4 functions as the main brake but is also dependent on TCR signals and interactions with CD80 (show CD80 Proteins)/CD86 (show CD86 Proteins)

  7. CTLA-4(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.

  8. this study shows that miR (show MLXIP Proteins)-155 is modulated by a major dust mite allergen, Dermatophagoides farinae (Df1), and increases CD4 (show CD4 Proteins)+ T cell proliferation through the downregulation of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expression

  9. CTLA-4 regulates atherosclerosis by suppressing proatherogenic immune responses.

  10. Data suggest enhanced clinical benefit from combining CTLA-4 antigen blockade with poxvirus-based active immunotherapy.

Human Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. These results indicate that CTLA-4 expression in the tumor environment of esophageal carcinoma is associated with poorer prognosis

  2. Of several immunotherapies being investigated, antibodies that target the programmed cell death protein-1 (show PDCD1 Proteins) (nivolumab and pembrolizumab) and cytotoxic T-lymphocyte antigen-4 (ipilimumab) immune checkpoint pathways are among the most promising for patients with Small cell lung cancer (SCLC), and are the focus of this review.

  3. In oncology, the two main classes of Checkpoint inhibitors (CPI), which are the most advanced in clinical development are the anti-CTLA-4 and anti-PD-1/PD-L1 antibodies (Abs). Three of these Abs have been approved by the FDA for clinical use.CPI can have efficacy across several types of cancer.

  4. No significant associations with RHD were found for the IL1RN (show IL1RN Proteins) rs447713 and CTLA4 rs3087243 SNPs.

  5. Data show that interleukin-21 (show IL21 Proteins)-primed cytotoxic T-cell lymphocytes (CTL) with cytotoxic T-lymphocyte associated protein 4 (CTLA-4) blockade is safe and produces durable clinical responses.

  6. Analysis of copy number alterations identified a higher burden of copy number loss in nonresponders to CTLA-4 and PD-1 (show PDCD1 Proteins) blockade and found that it was associated with decreased expression of genes in immune-related pathways.

  7. the upregulation of others syncytial molecules, including LAG3 (show LAG3 Proteins), CTLA4, CD28 (show CD28 Proteins) and CD3 (show CD3 Proteins), assisting the formation of syncytia with APC (show APC Proteins) cells.

  8. Tregs were observed to regulate CD4 (show CD4 Proteins)(+), but not CD8 (show CD8A Proteins)(+), T cell infiltration into tumors through a CTLA-4/CD80 (show CD80 Proteins) dependent mechanism. Disrupting CTLA-4 interaction with CD80 (show CD80 Proteins) was sufficient to induce CD4 (show CD4 Proteins) T cell infiltration into tumors.

  9. Our study reports a novel association of SNPs within CD86 (show CD86 Proteins) and CTLA4 genes with pemphigus. The CD86 (show CD86 Proteins) rs1129055 A allele appears to confer susceptibility to Pemphigus vulgaris (show DSG3 Proteins) but not to pemphigus foliaceus (show DSG1 Proteins).

  10. nasopharyngeal carcinoma patients with high tumor CTLA-4 expression had a poorer prognosis than those with low expression.

Pig (Porcine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Suggest a truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin as a novel approach for in vivo depletion of CD80 (show CD80 Proteins)-positive cells.

Cow (Bovine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. The surface expression of CTLA-4 was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 (show ZAP70 Proteins) were decreased in CD4 (show CD4 Proteins)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

  2. These results suggested that the expression level of CTLA-4 in CD4 (show CD4 Proteins)-positive T cells has a potentially immunosuppressive function in bovine leukemia infection.

  3. Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 (show FOXP3 Proteins) and CTLA4.

CTLA4 Protein Profile

Protein Summary

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Gene names and symbols associated with CTLA4

  • cytotoxic T-lymphocyte associated protein 4 (CTLA4)
  • cytotoxic T-lymphocyte-associated protein 4 (Ctla4)
  • CD protein
  • Cd152 protein
  • CELIAC3 protein
  • Ctla-4 protein
  • CTLA4 protein
  • GRD4 protein
  • GSE protein
  • IDDM12 protein
  • Ly-56 protein
  • sCTLA4 protein

Protein level used designations for CTLA4

cytotoxic T-lymphocyte-associated protein 4 precursor , CD152 protein , cytotoxic T-lymphocyte protein 4 , cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM , cytotoxic T-lymphocyte-associated protein 4 , costimulatory molecule B7 receptor , cytotoxic T lymphocyte-associated antigen 4 , CD152 antigen , cytotoxic T-lymphocyte-associated antigen 4 , CD152 isoform , celiac disease 3 , cytotoxic T lymphocyte associated antigen 4 short spliced form , cytotoxic T-lymphocyte antigen 4 , cytotoxic T-lymphocyte-associated serine esterase-4 , ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 , soluble form , transmembrane form , CTLA-4 , cytotoxic T lymphocyte-associated protein 4 , costimulatory molecule B7 receptor CD152

GENE ID SPECIES
443040 Ovis aries
705673 Macaca mulatta
100222727 Taeniopygia guttata
424106 Gallus gallus
470619 Pan troglodytes
493743 Felis catus
100126716 Papio anubis
12477 Mus musculus
1493 Homo sapiens
63835 Rattus norvegicus
100009412 Oryctolagus cuniculus
397286 Sus scrofa
403696 Canis lupus familiaris
281732 Bos taurus
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