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DAOA encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Additionally we are shipping D-Amino Acid Oxidase Activator Antibodies (20) and D-Amino Acid Oxidase Activator Kits (6) and many more products for this protein.
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DAOA gene may contribute to the risk for Psychotic disorders and that this gene may play a role as a modulator of executive function.
pLG72 level being significantly increased in the serum of patients with schizophrenia, have led us to propose that the ROS (show ROS1 Proteins) enhancement in mental diseases may be from the overexpression of pLG72 in brain cells.
Report in silico analysis of DAOA for the design of inhibitors for treatment of schizophrenia.
This study suggested that structural lipid alterations in oligodendrocyte glycosynapses are responsible for dysconnectivity in schizophrenia and that increased expression of G72 protein may play a role in the development of abnormal glycosynapses.
DAOA (or G72) gene encodes for a protein that binds to and activates the D-serine amino acid oxidase that acts as a coactivator of the glycine binding site on the glutamatergic N-methyl D-aspartate (NMDA) receptor.
the mitochondrial methionine-R-sulfoxide reductase B2 (MSRB2 (show MSRB2 Proteins)) is a specific interaction partner of LG72.
DAOA genetic polymorphism were not found to confer a statistically significant increased risk of Schizophrenia, bipolar disorder or depressive disorder.
Suggest chronic nicotine administration improves cognitive symptoms in G72 mouse model of schizophrenia.
study reports G72/G30 expression profiles and behavioral changes in a G72/G30 transgenic mouse model; the transcriptome profile changes and multiple mouse behavioral effects suggest that the G72 gene may play a role in modulating behaviors relevant to psychiatric disorders
Results demonstrate that expression of the human G72/G30 gene locus in mice produces behavioral phenotypes that are relevant to schizophrenia and implicate LG72-induced mitochondrial and synaptic defects as a possible pathomechanism of this disease.
tadpoles contained high concentrations of D-proline close to the final developmental stage and nearly no D-amino acids were detected in the adult frog, indicating that D-amino acid oxidase (show DAO Proteins) functions in metamorphosis.
This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
, schizophrenia- and bipolar disorder-associated protein G72
, D-amino-acid oxidase
, D-amino acid oxidase
, D-amino-acid oxidase-like