D-Amino Acid Oxidase Activator Proteins (DAOA)

DAOA encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Additionally we are shipping D-Amino Acid Oxidase Activator Antibodies (19) and D-Amino Acid Oxidase Activator Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DAOA 267012 P59103
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Top D-Amino Acid Oxidase Activator Proteins at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
$341.00
Details

DAOA Proteins by Origin and Source

Origin Expressed in Conjugate
Human
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More Proteins for D-Amino Acid Oxidase Activator (DAOA) Interaction Partners

Human D-Amino Acid Oxidase Activator (DAOA) interaction partners

  1. pLG72 interacts with neosynthesized d-amino acid oxidase (show DAO Proteins) (hDAAO), promoting its inactivation and degradation. In this work, we used low-resolution techniques to characterize the surface topology of the hDAAO-pLG72 complex.

  2. Data show that the R30K D-amino acid oxidase activator pLG72 is significantly more prone to degradation than the R30 and the K62E variants in a cell system.

  3. Studies successfully predicted the structures of the N- and C-terminal domains (ND and CD, respectively) of G72.

  4. We suggest that serum G72 protein levels may represent a candidate biomarker for schizophrenia and have confirmed the results of the previous preliminary study.

  5. A Mutation in DAOA Modifies the Age of Onset in PSEN1 (show PSEN1 Proteins) E280A Alzheimer's Disease. Findings strongly suggest that this new conspicuous functional age of onset modifier within the G72 (DAOA) gene could be pivotal for understanding the genetic basis of Alzheimer's disease.

  6. DAOA gene may contribute to the risk for Psychotic disorders and that this gene may play a role as a modulator of executive function.

  7. pLG72 level being significantly increased in the serum of patients with schizophrenia, have led us to propose that the ROS (show ROS1 Proteins) enhancement in mental diseases may be from the overexpression of pLG72 in brain cells.

  8. Report in silico analysis of DAOA for the design of inhibitors for treatment of schizophrenia.

  9. This study suggested that structural lipid alterations in oligodendrocyte glycosynapses are responsible for dysconnectivity in schizophrenia and that increased expression of G72 protein may play a role in the development of abnormal glycosynapses.

  10. DAOA (or G72) gene encodes for a protein that binds to and activates the D-serine amino acid oxidase that acts as a coactivator of the glycine binding site on the glutamatergic N-methyl D-aspartate (NMDA) receptor.

Xenopus laevis D-Amino Acid Oxidase Activator (DAOA) interaction partners

  1. tadpoles contained high concentrations of D-proline close to the final developmental stage and nearly no D-amino acids were detected in the adult frog, indicating that D-amino acid oxidase (show DAO Proteins) functions in metamorphosis.

D-Amino Acid Oxidase Activator (DAOA) Protein Profile

Protein Summary

This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with DAOA

  • D-amino acid oxidase activator (DAOA)
  • D-amino-acid oxidase (DAO)
  • D-amino-acid oxidase (dao)
  • D-amino-acid oxidase (SJAG_02496)
  • D-amino acid oxidase (Dao)
  • D-amino-acid oxidase (oxda)
  • daao protein
  • damox protein
  • DAO protein
  • DKFZp469N2232 protein
  • LG72 protein
  • MGC114783 protein
  • oxda protein
  • SG72 protein

Protein level used designations for DAOA

G72 transcript , schizophrenia- and bipolar disorder-associated protein G72 , D-amino-acid oxidase , D-amino acid oxidase , D-amino-acid oxidase-like

GENE ID SPECIES
267012 Homo sapiens
416894 Gallus gallus
706373 Macaca mulatta
735104 Xenopus laevis
743881 Pan troglodytes
7049247 Schizosaccharomyces japonicus yFS275
9794199 Arthrobacter arilaitensis Re117
100036595 Xenopus (Silurana) tropicalis
100171568 Pongo abelii
100192327 Cavia porcellus
100306742 Salmo salar
100414426 Callithrix jacchus
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