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The protein encoded by DDO is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Additionally we are shipping D-Aspartate Oxidase Antibodies (55) and D-Aspartate Oxidase Kits (12) and many more products for this protein.
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In this framework, an epiallele is defined as a specific combination of methylated CpG within Ddo locus and can represent the epigenetic haplotype revealing a cell-to-cell methylation heterogeneity.
This study demonstraed that age-related reduction of free d-Asp (show C3 Proteins) levels in the mouse brain in dod (show PIN1 Proteins) knockout mice.
Ddo(-/-) mice display a significant reduction in schizophrenia related symptoms induced by phencyclidine. Increased D-aspartate in Ddo(-/-) animals affect the development of cortico-hippocampal connectivity networks potentially involved in schizophrenia.
Arg-216 and Arg-237 play crucial roles in the substrate specificity of DDO.
reports that the behavioral phenotype of the Dco (show CSNK1E Proteins)-/- mouse is characterized by deficits in prepulse inhibition of the acoustic startle reflex and in motor coordination on the RotoRod
Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes
There is a significant increase in DDO mRNA expression in the prefrontal cortex of patients with schizophrenia compared to controls.
data do not suggest that DDO plays a role in the etiology of schizophrenia in the German population
crystal of D-aspartate oxidase belonged to space group P2(1), with unit-cell parameters a = 79.38, b = 144.0, c = 80.46 A, beta = 101.1 degrees , and diffracted to 1.80 A resolution
newly identified D-aspartate oxidase-positive cells seem to actively degrade D-Asp (show ASIP Proteins) to prevent an excess of D-Asp (show ASIP Proteins) from exerting harmful effects on the respective functions of porcine tissues
DDO plays important roles to prevent undesirable off-target action of D-aspartate by strictly controlling local D-aspartate concentration in the pituitary and pineal glands
kinetic properties of DDO suggested that at high substrate concentrations, the FAD (show PSEN1 Proteins)-reduced form of the enzyme also catalyzes the reaction: the oxidative half-reaction precedes the reductive one.
The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene.
, d-aspartate oxidase
, D-aspartate oxidase, DDO
, aspartic oxidase