You are viewing an incomplete version of our website. Please click to reload the website as full version.

DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 Proteins (DCUN1D1)

Part of an E3 ubiquitin ligase complex for neddylation.

list all proteins Gene Name GeneID UniProt
DCUN1D1 54165 Q96GG9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 Proteins at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

DCUN1D1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1) Interaction Partners

Human DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1) interaction partners

  1. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.

  2. SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO

  3. Distinct preferences of UBC12 (show ube2m Proteins) and UBE2F (show UBE2F Proteins) peptides for inhibiting different DCNLs, including the oncogenic DCNL1.

  4. substrate engagement prompts DCNL1 recruitment that facilitates the initiation of CUL2 (show CUL2 Proteins) neddylation and define DCNL1 as a "substrate sensor switch" for ECV activation.

  5. a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.

  6. Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors.

  7. SCCRO regulates Gli1 (show GLI1 Proteins)--a key regulator of the hedgehog (show SHH Proteins) (HH) pathway.

  8. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

  9. SCCRO-induced invasion involves activation of MMP2 (show MMP2 Proteins) transcription in an AP2 (show GTF3A Proteins)- and p53 (show TP53 Proteins)-dependent manner.

  10. The GG genotype of the DCUN1D1 rs4859147 Single Nucleotide Polymorphism represents a risk factor for the development of frontotemporal lobar degeneration , increasing the risk of about fourfold.

DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1) Protein Profile

Protein Summary

Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Gene names and symbols associated with DCUN1D1

  • DCN1, defective in cullin neddylation 1, domain containing 1 (DCUN1D1)
  • DCNL1 protein
  • DCUN1L1 protein
  • RP42 protein
  • SCCRO protein
  • SCRO protein
  • Tes3 protein

Protein level used designations for DCUN1D1

DCN1-like protein 1 , DCUN1 domain-containing protein 1 , RP42 homolog , defective in cullin neddylation protein 1-like protein 1 , squamous cell carcinoma related oncogene , squamous cell carcinoma-related oncogene

GENE ID SPECIES
54165 Homo sapiens
Selected quality suppliers for DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 Proteins (DCUN1D1)
Did you look for something else?