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Part of an E3 ubiquitin ligase complex for neddylation.
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The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO
Distinct preferences of UBC12 (show ube2m Proteins) and UBE2F (show UBE2F Proteins) peptides for inhibiting different DCNLs, including the oncogenic DCNL1.
substrate engagement prompts DCNL1 recruitment that facilitates the initiation of CUL2 (show CUL2 Proteins) neddylation and define DCNL1 as a "substrate sensor switch" for ECV activation.
a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.
Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors.
SCCRO regulates Gli1 (show GLI1 Proteins)--a key regulator of the hedgehog (show SHH Proteins) (HH) pathway.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
SCCRO-induced invasion involves activation of MMP2 (show MMP2 Proteins) transcription in an AP2 (show GTF3A Proteins)- and p53 (show TP53 Proteins)-dependent manner.
The GG genotype of the DCUN1D1 rs4859147 Single Nucleotide Polymorphism represents a risk factor for the development of frontotemporal lobar degeneration , increasing the risk of about fourfold.
Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
DCN1-like protein 1
, DCUN1 domain-containing protein 1
, RP42 homolog
, defective in cullin neddylation protein 1-like protein 1
, squamous cell carcinoma related oncogene
, squamous cell carcinoma-related oncogene