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The protein encoded by DCP2 is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). Additionally we are shipping DCP2 Antibodies (53) and DCP2 Proteins (6) and many more products for this protein.
ERK (show EPHB2 ELISA Kits)-phosphorylated Dcp1a (show DCP1A ELISA Kits) enhances its interaction with the decapping enzyme (show DCP1A ELISA Kits) Dcp2 during early differentiation of 3T3-L1 cells.
Recruitment of DCP1A (show DCP1A ELISA Kits) and DCP2 increases the mRNA degradation capacity of the maturing oocyte so that by the 2-cell stage, most of the maternal mRNA is degraded.
The results showed that DCP1A (show DCP1A ELISA Kits) and DCP2 are critical in the transition from mRNA stability to instability during meiotic maturation and that mRNA degradation must be successful to execute the oocyte-to-zygote transition.
In this study the increase in Irf-7 (show IRF7 ELISA Kits) mRNA within the background of reduced Dcp2 levels was attributed to a stabilization of the Irf-7 (show IRF7 ELISA Kits) mRNA, suggesting that Dcp2 normally modulates Irf-7 (show IRF7 ELISA Kits) mRNA stability.
Like Dcp2, Nudt16 (show NUDT16 ELISA Kits) also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis.
Human Dcp2 levels and activity are controlled by a competition between decapping complex assembly and Dcp2 degradation.
The data indicates that DCP2 activation by DCP1 (show ACE ELISA Kits) occurs preferentially on the EDC4 (show EDC4 ELISA Kits) scaffold, which may serve to couple DCP2 activation by DCP1 (show ACE ELISA Kits) with 5'-to-3' mRNA degradation by XRN1 (show XRN1 ELISA Kits) in human cells.
Data show that Y14 (show RBM8A ELISA Kits) interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping domains.
PNRC2 (show PNRC2 ELISA Kits) acts in synergy with Dcp1a (show DCP1A ELISA Kits) to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a (show DCP1A ELISA Kits) and Dcp2.
an mRNA decapping enzyme (show DCPS ELISA Kits) demonstrated to contain intrinsic decapping activity
Human Dcp2 is a catalytically active mRNA decapping enzyme (show DCPS ELISA Kits) that localizes to the cytoplasm
LSm1 (show LSM1 ELISA Kits)-7 proteins colocalize with DCP1 (show ACE ELISA Kits),DCP2 and Xrn1 (show XRN1 ELISA Kits) in cytoplasmic foci
These data support the novel notion of the association between Ro52 (show TRIM21 ELISA Kits) with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation.
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
mRNA-decapping enzyme 2
, DCP2 decapping enzyme homolog
, m7GpppN-mRNA hydrolase
, nudix (nucleoside diphosphate linked moiety X)-type motif 20