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DCAF7 encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. Additionally we are shipping DCAF7 Proteins (6) and many more products for this protein.
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we show that while a GFP-Wdr68 fusion functionally substituted for craniofacial development in the zebrafish, that a Nuclear Export Signal (NES (show NES Antibodies)) fusion protein (GFPNESWdr68) failed to support craniofacial development
The initial characterization of wdr68 suggests an important role in craniofacial development for the highly conserved Wdr68-Dyrk1 (show DYRK1A Antibodies) protein complexes.
results demonstrate that the molecular chaperone (show HSP90AA1 Antibodies) TRiC/CCT (show TCP1 Antibodies) is essential for correct protein folding, DYRK1A (show DYRK1A Antibodies) binding, and nuclear accumulation of WDR68.
DYRK1A (show DYRK1A Antibodies) binds specifically to WDR68 in cells; the binding, but not the phosphorylation event, induces the nuclear translocation of WDR68.
Han11 was required to allow coupling of MEKK1 (show MAP3K1 Antibodies) to DYRK1 (show DYRK1A Antibodies) and HIPK2 (show HIPK2 Antibodies).
that AN11 may be a physiological regulator of GLI1 (show GLI1 Antibodies) transcriptional activity
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signalling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants.
DDB1- and CUL4-associated factor 7
, dirty south
, AN11 homolog
, WD repeat domain 68
, DDB1 and CUL4 associated factor 7
, WD-repeat protein
, WD repeat-containing protein 68
, WD repeat-containing protein An11 homolog
, human anthocyanin
, seven-WD-repeat protein of the AN11 family-1