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DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 Proteins (DDX58)

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. Additionally we are shipping DDX58 Antibodies (170) and DDX58 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DDX58 23586 O95786
DDX58 230073 Q6Q899
Rat DDX58 DDX58 297989  
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Top DDX58 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 16 Days
$818.13
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
$831.88
Details

DDX58 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,

Top referenced DDX58 Proteins

  1. Human DDX58 Protein expressed in Human - ABIN2719304 : Zhao, Tian, Edeh, Brasier: Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry. in Molecular & cellular proteomics : MCP 2013 (PubMed)

More Proteins for DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Interaction Partners

Human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Modulates RIG-I-dependent antiviral response is through post-translational modifications of or protein-protein interactions with RIG-I. [review]

  2. Study demonstrates how the coordinated interplay of RIG-I, TRIM25 (show TRIM25 Proteins), and FAT10 (show UBD Proteins) regulate the antiviral innate inflammatory response.

  3. Pyruvate carboxylase activates the RIG-I-like receptor-mediated antiviral immune response by targeting the MAVS (show MAVS Proteins) signalosome.

  4. This study shows that RIG-I activation results in MKP-1 (show DUSP1 Proteins)-mediated inhibition of cell proliferation in melanoma cells via controlling the p38 (show CRK Proteins)-HSP27 (show HSPB1 Proteins), c-Jun (show JUN Proteins) and rpS6 (show RPS6 Proteins) pathways

  5. HepaRG cells express a similar pattern of functional TLR/RLR (show DHX58 Proteins) as compared to PHH, thus qualifying HepaRG cells as a surrogate model to study pathogen interactions within a hepatocyte innate system.

  6. COPD (show ARCN1 Proteins) patients had higher interleukin (IL)-1 (show IL1A Proteins) and IL-8 (show IL8 Proteins) mRNA expression levels, and these inflammatory cytokines positively correlate with MDA-5 (show IFIH1 Proteins) levels. However, there was no difference in the expression of RIG-I between COPD (show ARCN1 Proteins) patients and control subjects.

  7. In cell culture, Marburg virus infection results in a greater upregulation of IFN responses as compared to Ebolavirus infection, which correlates with differences in the efficiencies by which EBOV and MARV VP35s antagonize RIG-I signaling.

  8. These findings collectively support the conclusion that IKK (show CHUK Proteins) modulates innate immune signaling cascades via phosphorylating the RIG-I cytosolic sensor, providing a feedback regulatory mechanism.

  9. ATP hydrolysis displaces wild-type RIG-I from this self-RNA but not from 5' triphosphate dsRNA.

  10. that miR-4516 mediated down-regulation of UBE2N promotes p53 nuclear translocation and pro-apoptotic activity of PUVA is independent of IRF3 but is mediated by the RIG-I in a p53 and NFkappaB dependent manner

Mouse (Murine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation

  2. identifies DDX58 and MTHFSD as two TDP-43 (show TARDBP Proteins) targets that are misregulated in amyotrophic lateral sclerosis. 1

  3. Data show that preconditioning with poly(I:C) alters toll (show TLR4 Proteins)-like receptors (TLR) and RIG-I-like receptors (RLRs) responses in opposite directions.

  4. Cytosolic LMW FGF2 (show FGF2 Proteins) functions as a negative regulator in RIG-I-mediated antiviral signaling.

  5. results indicate that Lyn (show LYN Proteins) plays a positive regulatory role in RIG-I-mediated interferon (show IFNA Proteins) expression as a downstream component of IPS-1 (show ISYNA1 Proteins)

  6. In lung epithelial cells, retinoic acid-inducible gene-1 (show RARRES3 Proteins) (RIG-I) was identified as the major RIG-I-like receptor required for RSV-induced protease expression via MAVS (show MAVS Proteins).

  7. findings suggest that RIG-I directs a typical IFN-dependent antiviral response against an RNA virus capable of suppressing the RNAi response

  8. The results describe a novel, interactive relationship between RIG-I downstream signalling molecules resulting in efficient anti-viral immunity.

  9. senses hepatitis B virus RNA, and counteracts HBV polymerase

  10. RIG-I-like receptor (RLR (show DHX58 Proteins)) signaling pathway was significantly affected by Yersinia pestis infection

Pig (Porcine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Viral RNA polymerase components PB2, PB1, and PA directly target RIG-I.

  2. These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 (show IFIH1 Proteins) to initiate the RIG-I signaling pathway to trigger innate defenses against infection.

  3. DDX58 had two nonsynonymous SNPs in the helicase domain.

DDX58 Protein Profile

Protein Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.

Gene names and symbols associated with DDX58

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58)
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Ddx58)
  • 6430573D20Rik protein
  • C330021E21 protein
  • RHIV-1 protein
  • RIG-1 protein
  • RIG-I protein
  • RIGI protein
  • RLR-1 protein

Protein level used designations for DDX58

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I , probable ATP-dependent RNA helicase DDX58 , putative ATP-dependent RNA helicase DDX58 , retinoic acid-inducible protein I , DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 , probable ATP-dependent RNA helicase DDX58-like , DEAD box protein 58 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide , RIG-1 , RIG-I-like receptor 1 , RNA helicase RIG-I , retinoic acid inducible gene I , retinoic acid-inducible gene 1 protein , retinoic acid-inducible gene I protein , DEAD-box protein 58 , DEAD/H box polypeptide RIG-I , retinoic acid-inducible gene-I , RNA helicase induced by virus

GENE ID SPECIES
465035 Pan troglodytes
704638 Macaca mulatta
100067920 Equus caballus
100347707 Oryctolagus cuniculus
100408692 Callithrix jacchus
100443290 Pongo abelii
23586 Homo sapiens
230073 Mus musculus
297989 Rattus norvegicus
100686785 Canis lupus familiaris
396723 Sus scrofa
504760 Bos taurus
101107257 Ovis aries
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