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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Additionally we are shipping DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 Kits (19) and DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 Proteins (4) and many more products for this protein.
Showing 10 out of 67 products:
Human Polyclonal DDX11 Primary Antibody for FACS, WB - ABIN655503
Leman, Noguchi, Lee, Noguchi: Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion. in Journal of cell science 2010
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Human Polyclonal DDX11 Primary Antibody for EIA, FACS - ABIN951861
Parish, Bean, Park, Androphy: ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance. in Molecular cell 2006
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Human Polyclonal DDX11 Primary Antibody for EIA, FACS - ABIN951862
Farina, Shin, Kim, Bermudez, Kelman, Seo, Hurwitz: Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. in The Journal of biological chemistry 2008
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Human Polyclonal DDX11 Primary Antibody for FACS, WB - ABIN654411
Parish, Rosa, Wang, Lahti, Doxsey, Androphy: The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. in Journal of cell science 2006
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In this study, we found that cohesion establishment factors, like CHlR1, cooperatively stimulate endonuclease activity of hFen1 in in vivo mimic condition, including replication protein-A (show GPR153 Antibodies)-coated DNA and high salt.
DDX11 and Tim proteins physically and functionally interact and act in concert to preserve replication fork progression in perturbed conditions.
Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase
our results indicate that DDX11 functions as a positive regulator of rRNA transcription and provides a novel insight into the pathogenesis of WABS.
A distinct triplex DNA unwinding activity of ChlR1 helicase.
ChlR1 plays a critically important role in cellular replication and/or DNA repair. [review]
Data indicate a homozygous mutation (c.788G>A [p.R263Q]) in DDX11 in three affected siblings with severe intellectual disability and many of the congenital abnormalities reported in the Warsaw breakage syndrome (WABS) original case.
helicase DDX11 is expressed at high levels in primary and metastatic melanoma, and that interfering with its expression leads to severe chromosome segregation defects, telomere shortening, and massive melanoma cell apoptosis.
The results identify novel roles of Ddx11 during embryo morphogenesis and demonstrate that the activity of its motif V is essential for DDX11 function.
Wild-type ChlR1 required a minimal 5' single-stranded DNA tail of 15 nucleotides to efficiently unwind a simple duplex DNA substrate.
ChlR1 is essential for embryonic development and the prevention of aneuploidy in mammals.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
, CHL1-like helicase homolog
, CHL1-related helicase gene-1
, CHL1-related protein 1
, DEAD/H box protein 11
, keratinocyte growth factor-regulated gene 2 protein
, probable ATP-dependent RNA helicase DDX11