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DENN/MADD Domain Containing 1A Proteins (DENND1A)

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Additionally we are shipping DENN/MADD Domain Containing 1A Antibodies (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat DENND1A DENND1A 311913  
DENND1A 57706 Q8TEH3
DENND1A 227801 Q8K382
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Top DENN/MADD Domain Containing 1A Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

DENND1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for DENN/MADD Domain Containing 1A (DENND1A) Interaction Partners

Human DENN/MADD Domain Containing 1A (DENND1A) interaction partners

  1. The guanine nucleotide exchange factor (show RASGRF1 Proteins) activity of connecdenn 1 and 2 are autoinhibited, and this is regulated by Akt (show AKT1 Proteins) activation downstream of insulin (show INS Proteins) stimulation.

  2. We demonstrated lack of association of DENND1A SNPs rs10818854, rs2479106, and rs10986105, previously associated with PCOS in Asians, with PCOS in Bahraini Arab women.

  3. sequence analysis of the DENND1A gene of patients with PCOS did not identify alterations that alone could be responsible for the PCOS pathogenesis

  4. DENND1A, plays a key role in the hyperandrogenemia associated with polycystic ovary syndrome.

  5. THADA and DENND1A, carry risk alleles that are associated with endocrine and metabolic disturbances in PCOS patients of Han Chinese descent.

  6. Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR (show LHCGR Proteins) are associated with endometrioid adenocarcinoma.

  7. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry.

  8. At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations.

Mouse (Murine) DENN/MADD Domain Containing 1A (DENND1A) interaction partners

  1. Connecdenn is a component of the endocytic machinery functioning in synaptic vesicle endocytosis, providing the first evidence of a role for a DENN domain-containing protein in endocytosis.

DENN/MADD Domain Containing 1A (DENND1A) Protein Profile

Protein Summary

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2\; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010

Gene names and symbols associated with DENND1A

  • DENN/MADD domain containing 1A (Dennd1a)
  • DENN/MADD domain containing 1A (DENND1A)
  • DENN/MADD domain containing 1A (dennd1a)
  • DENN/MADD domain containing 1A (LOC100219282)
  • 6030446I19Rik protein
  • connecdenn protein
  • fam31a protein
  • KIAA1608 protein
  • RGD1307927 protein
  • RP11-230L22.3 protein

Protein level used designations for DENND1A

DENN domain-containing protein 1A , DENN/MADD domain containing 1A , connecdenn 1 , connecdenn

GENE ID SPECIES
311913 Rattus norvegicus
417102 Gallus gallus
473055 Pan troglodytes
514134 Bos taurus
556150 Danio rerio
609706 Canis lupus familiaris
698028 Macaca mulatta
100018155 Monodelphis domestica
100067362 Equus caballus
100219282 Taeniopygia guttata
100340700 Oryctolagus cuniculus
100384916 Callithrix jacchus
100471360 Ailuropoda melanoleuca
100512328 Sus scrofa
100550463 Meleagris gallopavo
100592544 Nomascus leucogenys
57706 Homo sapiens
227801 Mus musculus
447295 Xenopus laevis
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