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anti-DENN/MADD Domain Containing 1B (DENND1B) Antibodies

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Additionally we are shipping DENND1B Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DENND1B 163486 Q6P3S1
DENND1B 329260 Q3U1T9
DENND1B 289051  
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Top anti-DENND1B Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-DENND1B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-DENND1B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of NCI-H460 cells using DENND1B Antibody (N-term) Cat.-No AP51240PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin fixed, paraffin embedded human lymph tissue stained with DENND1B Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB DENND1B Antibody (N-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the DENND1B antibody detected the DENND1B protein (arrow). DENND1B antibody (N-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the DENND1B antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using DENND1B, antibody at 1:200 dilution. WB Image Sample (30 ug of whole cell lysate) A: MOLT4 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ICC, WB   100 μL Log in to see 8 to 10 Days
$507.83
Details

DENND1B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DENND1B Antibodies

  1. Human Polyclonal DENND1B Primary Antibody for EIA, FACS - ABIN951885 : Marat, McPherson: The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN951885

  2. Chicken Polyclonal DENND1B Primary Antibody for WB - ABIN2785086 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)

More Antibodies against DENND1B Interaction Partners

Human DENN/MADD Domain Containing 1B (DENND1B) interaction partners

  1. Study reveals a previously unrecognized mechanism by which DENND1B regulates surface TCR dynamics to fine-tune TH2 cell signaling and effector functions. Dennd1b-/- TH2 cells exhibit delayed TCR downmodulation following TCR activation that is associated with enhanced TCR signaling and greater transcriptional activation and secretion of TH2-associated cytokines.

  2. Increased fraction of exhaled nitric oxide in healthy newborns seems strongly influenced by genetics including father's atopy and child's variants in the DENND1B locus at chromosome 1q31.3.

  3. The guanine nucleotide exchange factor (show RASGRF1 Antibodies) activity of connecdenn 1 (show DENND1A Antibodies) and 2 are autoinhibited, and this is regulated by Akt (show AKT1 Antibodies) activation downstream of insulin (show INS Antibodies) stimulation.

  4. Data indicate that folliculin (show FLCN Antibodies)-CT is structurally similar to the DENN (show MADD Antibodies) domain of DENND1B.

  5. analysis of DENND1B-S complexed with its substrate Rab35 (show RAB35 Antibodies)

  6. We have identified a locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma.

Mouse (Murine) DENN/MADD Domain Containing 1B (DENND1B) interaction partners

  1. Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge. Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines.

DENND1B Antigen Profile

Protein Summary

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2\; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010

Gene names and symbols associated with DENND1B

  • DENN/MADD domain containing 1B (DENND1B) antibody
  • DENN/MADD domain containing 1B (LOC100220925) antibody
  • DENN/MADD domain containing 1B (LOC100338926) antibody
  • DENN/MADD domain containing 1B (dennd1b) antibody
  • DENN/MADD domain containing 1B (Dennd1b) antibody
  • 4632404N19Rik antibody
  • 4930467M19Rik antibody
  • 6820401H01Rik antibody
  • C1ORF18 antibody
  • C1orf218 antibody
  • F730008N07Rik antibody
  • Fam31b antibody
  • si:ch211-195i21.1 antibody

Protein level used designations for DENND1B

DENN/MADD domain containing 1B , DENN domain-containing protein 1B-like , DENN domain-containing protein 1B , connecdenn 2 , family with sequence similarity 31, member B , ASL1/9AS1-1 fusion

GENE ID SPECIES
100061134 Equus caballus
469627 Pan troglodytes
713131 Macaca mulatta
100026686 Monodelphis domestica
100074528 Ornithorhynchus anatinus
100220925 Taeniopygia guttata
100338926 Oryctolagus cuniculus
100386266 Callithrix jacchus
100566253 Anolis carolinensis
100603306 Nomascus leucogenys
163486 Homo sapiens
329260 Mus musculus
289051 Rattus norvegicus
560720 Danio rerio
424351 Gallus gallus
490259 Canis lupus familiaris
515939 Bos taurus
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