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Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Additionally we are shipping DENND1B Proteins (4) and many more products for this protein.
Showing 10 out of 46 products:
Human Polyclonal DENND1B Primary Antibody for EIA, FACS - ABIN951885
Marat, McPherson: The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. in The Journal of biological chemistry 2010
Show all 3 references for ABIN951885
Human Polyclonal DENND1B Primary Antibody for WB - ABIN2785085
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Study reveals a previously unrecognized mechanism by which DENND1B regulates surface TCR dynamics to fine-tune TH2 cell signaling and effector functions. Dennd1b-/- TH2 cells exhibit delayed TCR downmodulation following TCR activation that is associated with enhanced TCR signaling and greater transcriptional activation and secretion of TH2-associated cytokines.
Increased fraction of exhaled nitric oxide in healthy newborns seems strongly influenced by genetics including father's atopy and child's variants in the DENND1B locus at chromosome 1q31.3.
The guanine nucleotide exchange factor (show RASGRF1 Antibodies) activity of connecdenn 1 (show DENND1A Antibodies) and 2 are autoinhibited, and this is regulated by Akt (show AKT1 Antibodies) activation downstream of insulin (show INS Antibodies) stimulation.
Data indicate that folliculin (show FLCN Antibodies)-CT is structurally similar to the DENN (show MADD Antibodies) domain of DENND1B.
analysis of DENND1B-S complexed with its substrate Rab35 (show RAB35 Antibodies)
We have identified a locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma.
Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge. Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines.
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2\; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010
DENN/MADD domain containing 1B
, DENN domain-containing protein 1B-like
, DENN domain-containing protein 1B
, connecdenn 2
, family with sequence similarity 31, member B
, ASL1/9AS1-1 fusion