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DENN/MADD Domain Containing 1B (DENND1B) ELISA Kits

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Additionally we are shipping DENND1B Antibodies (49) and DENND1B Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human DENND1B DENND1B 163486 Q6P3S1
Anti-Mouse DENND1B DENND1B 329260 Q3U1T9
Anti-Rat DENND1B DENND1B 289051  
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More ELISA Kits for DENND1B Interaction Partners

Human DENN/MADD Domain Containing 1B (DENND1B) interaction partners

  1. Study reveals a previously unrecognized mechanism by which DENND1B regulates surface TCR dynamics to fine-tune TH2 cell signaling and effector functions. Dennd1b-/- TH2 cells exhibit delayed TCR downmodulation following TCR activation that is associated with enhanced TCR signaling and greater transcriptional activation and secretion of TH2-associated cytokines.

  2. Increased fraction of exhaled nitric oxide in healthy newborns seems strongly influenced by genetics including father's atopy and child's variants in the DENND1B locus at chromosome 1q31.3.

  3. The guanine nucleotide exchange factor (show RASGRF1 ELISA Kits) activity of connecdenn 1 (show DENND1A ELISA Kits) and 2 are autoinhibited, and this is regulated by Akt (show AKT1 ELISA Kits) activation downstream of insulin (show INS ELISA Kits) stimulation.

  4. Data indicate that folliculin (show FLCN ELISA Kits)-CT is structurally similar to the DENN (show MADD ELISA Kits) domain of DENND1B.

  5. analysis of DENND1B-S complexed with its substrate Rab35 (show RAB35 ELISA Kits)

  6. We have identified a locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma.

Mouse (Murine) DENN/MADD Domain Containing 1B (DENND1B) interaction partners

  1. Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge. Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines.

DENND1B Antigen Profile

Antigen Summary

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2\; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010

Gene names and symbols associated with DENND1B

  • DENN/MADD domain containing 1B (DENND1B) antibody
  • DENN/MADD domain containing 1B (LOC100220925) antibody
  • DENN/MADD domain containing 1B (LOC100338926) antibody
  • DENN/MADD domain containing 1B (dennd1b) antibody
  • DENN/MADD domain containing 1B (Dennd1b) antibody
  • 4632404N19Rik antibody
  • 4930467M19Rik antibody
  • 6820401H01Rik antibody
  • C1ORF18 antibody
  • C1orf218 antibody
  • F730008N07Rik antibody
  • Fam31b antibody
  • si:ch211-195i21.1 antibody

Protein level used designations for DENND1B

DENN/MADD domain containing 1B , DENN domain-containing protein 1B-like , DENN domain-containing protein 1B , connecdenn 2 , family with sequence similarity 31, member B , ASL1/9AS1-1 fusion

GENE ID SPECIES
100061134 Equus caballus
469627 Pan troglodytes
713131 Macaca mulatta
100026686 Monodelphis domestica
100074528 Ornithorhynchus anatinus
100220925 Taeniopygia guttata
100338926 Oryctolagus cuniculus
100386266 Callithrix jacchus
100566253 Anolis carolinensis
100603306 Nomascus leucogenys
163486 Homo sapiens
329260 Mus musculus
289051 Rattus norvegicus
560720 Danio rerio
424351 Gallus gallus
490259 Canis lupus familiaris
515939 Bos taurus
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