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DENN/MADD Domain Containing 1B Proteins (DENND1B)

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Additionally we are shipping DENND1B Antibodies (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DENND1B 163486 Q6P3S1
DENND1B 329260 Q3U1T9
Rat DENND1B DENND1B 289051  
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Top DENND1B Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

DENND1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for DENN/MADD Domain Containing 1B (DENND1B) Interaction Partners

Human DENN/MADD Domain Containing 1B (DENND1B) interaction partners

  1. Study reveals a previously unrecognized mechanism by which DENND1B regulates surface TCR dynamics to fine-tune TH2 cell signaling and effector functions. Dennd1b-/- TH2 cells exhibit delayed TCR downmodulation following TCR activation that is associated with enhanced TCR signaling and greater transcriptional activation and secretion of TH2-associated cytokines.

  2. Increased fraction of exhaled nitric oxide in healthy newborns seems strongly influenced by genetics including father's atopy and child's variants in the DENND1B locus at chromosome 1q31.3.

  3. The guanine nucleotide exchange factor (show RASGRF1 Proteins) activity of connecdenn 1 (show DENND1A Proteins) and 2 are autoinhibited, and this is regulated by Akt (show AKT1 Proteins) activation downstream of insulin (show INS Proteins) stimulation.

  4. Data indicate that folliculin (show FLCN Proteins)-CT is structurally similar to the DENN domain of DENND1B.

  5. analysis of DENND1B-S complexed with its substrate Rab35 (show RAB35 Proteins)

  6. We have identified a locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma.

Mouse (Murine) DENN/MADD Domain Containing 1B (DENND1B) interaction partners

  1. Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge. Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines.

DENND1B Protein Profile

Protein Summary

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2\; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010

Gene names and symbols associated with DENND1B

  • DENN/MADD domain containing 1B (DENND1B)
  • DENN/MADD domain containing 1B (LOC100220925)
  • DENN/MADD domain containing 1B (LOC100338926)
  • DENN/MADD domain containing 1B (dennd1b)
  • DENN/MADD domain containing 1B (Dennd1b)
  • 4632404N19Rik protein
  • 4930467M19Rik protein
  • 6820401H01Rik protein
  • C1ORF18 protein
  • C1orf218 protein
  • F730008N07Rik protein
  • Fam31b protein
  • si:ch211-195i21.1 protein

Protein level used designations for DENND1B

DENN/MADD domain containing 1B , DENN domain-containing protein 1B-like , DENN domain-containing protein 1B , connecdenn 2 , family with sequence similarity 31, member B , ASL1/9AS1-1 fusion

GENE ID SPECIES
100061134 Equus caballus
469627 Pan troglodytes
713131 Macaca mulatta
100026686 Monodelphis domestica
100074528 Ornithorhynchus anatinus
100220925 Taeniopygia guttata
100338926 Oryctolagus cuniculus
100386266 Callithrix jacchus
100566253 Anolis carolinensis
100603306 Nomascus leucogenys
163486 Homo sapiens
329260 Mus musculus
289051 Rattus norvegicus
560720 Danio rerio
424351 Gallus gallus
490259 Canis lupus familiaris
515939 Bos taurus
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