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Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Additionally we are shipping DENND1B Antibodies (51) and many more products for this protein.
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Study reveals a previously unrecognized mechanism by which DENND1B regulates surface TCR dynamics to fine-tune TH2 cell signaling and effector functions. Dennd1b-/- TH2 cells exhibit delayed TCR downmodulation following TCR activation that is associated with enhanced TCR signaling and greater transcriptional activation and secretion of TH2-associated cytokines.
Increased fraction of exhaled nitric oxide in healthy newborns seems strongly influenced by genetics including father's atopy and child's variants in the DENND1B locus at chromosome 1q31.3.
The guanine nucleotide exchange factor (show RASGRF1 Proteins) activity of connecdenn 1 (show DENND1A Proteins) and 2 are autoinhibited, and this is regulated by Akt (show AKT1 Proteins) activation downstream of insulin (show INS Proteins) stimulation.
Data indicate that folliculin (show FLCN Proteins)-CT is structurally similar to the DENN domain of DENND1B.
analysis of DENND1B-S complexed with its substrate Rab35 (show RAB35 Proteins)
We have identified a locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma.
Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge. Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines.
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2\; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010
DENN/MADD domain containing 1B
, DENN domain-containing protein 1B-like
, DENN domain-containing protein 1B
, connecdenn 2
, family with sequence similarity 31, member B
, ASL1/9AS1-1 fusion