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Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Additionally we are shipping DENN/MADD Domain Containing 1A Antibodies (18) and many more products for this protein.
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This meta-analysis suggested that rs2479106 and rs10818854 polymorphisms in the DENND1A gene were associated with increased risk of polycystic ovary syndrome
The guanine nucleotide exchange factor (show RASGRF1 Proteins) activity of connecdenn 1 and 2 are autoinhibited, and this is regulated by Akt (show AKT1 Proteins) activation downstream of insulin (show INS Proteins) stimulation.
We demonstrated lack of association of DENND1A SNPs rs10818854, rs2479106, and rs10986105, previously associated with PCOS in Asians, with PCOS in Bahraini Arab women.
sequence analysis of the DENND1A gene of patients with PCOS did not identify alterations that alone could be responsible for the PCOS pathogenesis
DENND1A, plays a key role in the hyperandrogenemia associated with polycystic ovary syndrome.
THADA and DENND1A, carry risk alleles that are associated with endocrine and metabolic disturbances in PCOS patients of Han Chinese descent.
Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR (show LHCGR Proteins) are associated with endometrioid adenocarcinoma.
Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry.
At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations.
Connecdenn is a component of the endocytic machinery functioning in synaptic vesicle endocytosis, providing the first evidence of a role for a DENN domain-containing protein in endocytosis.
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2\; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010
DENN domain-containing protein 1A
, DENN/MADD domain containing 1A
, connecdenn 1