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Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Additionally we are shipping DEP Domain Containing 2 Antibodies (8) and DEP Domain Containing 2 Kits (3) and many more products for this protein.
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The results of the present study suggested that PREX2a may act as an oncogene (show RAB1A Proteins) in osteosarcoma via the inhibition of PTEN activity and activation of PI3K (show PIK3CA Proteins) signaling.
findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator
second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation.
PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion.
CXCL9 (show CXCL9 Proteins) is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2.
Results demonstrate that miR (show MLXIP Proteins)-338-3p affects gastric cancer progression through PTEN-AKT (show AKT1 Proteins) signaling by targeting P-Rex2a in gastric cancer cells
P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin (show INS Proteins) sensitivity and glucose homeostasis
MiR (show MLXIP Proteins)-338-3p affects the PTEN/Akt (show AKT1 Proteins) pathway by down-regulating PREX2a.
Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 (show VAV3 Proteins) play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis.
Analysis of whole-genome sequence data identified PREX2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)--a PTEN-interacting protein and negative regulator of PTEN in breast cancer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independent extension cohort of 107 human melanomas
This study demonistrated that the P-Rex2, a GEF (show ARHGEF2 Proteins) that specifically activates Rac (show AKT1 Proteins) small GTPases, is expressed in a cell- and synapse-specific manner in the retina.
PI3K/P-Rex/Rac (show AKT1 Proteins) pathway is required for late phase long-term potentiation in the mouse cerebellum
P-Rex1 and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase (By similarity).
DEP domain-containing protein 2
, PtdIns(3,4,5)-dependent Rac exchanger 2
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
, DEP domain containing 2
, ptdIns(3,4,5)-dependent Rac exchanger 2