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DEP Domain Containing 2 Proteins (DEPDC2)

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Additionally we are shipping DEP Domain Containing 2 Antibodies (7) and DEP Domain Containing 2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DEPDC2 80243 Q70Z35
DEPDC2 109294 Q3LAC4
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Top DEP Domain Containing 2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DEPDC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for DEP Domain Containing 2 (DEPDC2) Interaction Partners

Human DEP Domain Containing 2 (DEPDC2) interaction partners

  1. findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator

  2. second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation.

  3. PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion.

  4. CXCL9 (show CXCL9 Proteins) is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2.

  5. Results demonstrate that miR (show MLXIP Proteins)-338-3p affects gastric cancer progression through PTEN-AKT (show AKT1 Proteins) signaling by targeting P-Rex2a in gastric cancer cells

  6. P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin (show INS Proteins) sensitivity and glucose homeostasis

  7. MiR (show MLXIP Proteins)-338-3p affects the PTEN/Akt (show AKT1 Proteins) pathway by down-regulating PREX2a.

  8. Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 (show VAV3 Proteins) play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis.

  9. Analysis of whole-genome sequence data identified PREX2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)--a PTEN-interacting protein and negative regulator of PTEN in breast cancer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independent extension cohort of 107 human melanomas

  10. suggests that aberrant control of PTEN by P-REX2a may represent a key tumorigenic mechanism, in agreement with recent studies supporting the pathological relevance of several other proposed PTEN regulators

Mouse (Murine) DEP Domain Containing 2 (DEPDC2) interaction partners

  1. P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin (show INS Proteins) sensitivity and glucose homeostasis

  2. This study demonistrated that the P-Rex2, a GEF (show ARHGEF2 Proteins) that specifically activates Rac (show AKT1 Proteins) small GTPases, is expressed in a cell- and synapse-specific manner in the retina.

  3. PI3K/P-Rex/Rac (show AKT1 Proteins) pathway is required for late phase long-term potentiation in the mouse cerebellum

  4. P-Rex1 and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function

DEP Domain Containing 2 (DEPDC2) Protein Profile

Protein Summary

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase (By similarity).

Gene names and symbols associated with DEPDC2

  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2)
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (Prex2)
  • 6230420N16Rik protein
  • AI316880 protein
  • AI553603 protein
  • C030045D06Rik protein
  • D430013K02 protein
  • DEP.2 protein
  • Depdc2 protein
  • P-Rex2 protein

Protein level used designations for DEPDC2

DEP domain-containing protein 2 , PtdIns(3,4,5)-dependent Rac exchanger 2 , phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein , DEP domain containing 2 , ptdIns(3,4,5)-dependent Rac exchanger 2

GENE ID SPECIES
80243 Homo sapiens
109294 Mus musculus
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