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Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Additionally we are shipping DEP Domain Containing 2 Kits (6) and DEP Domain Containing 2 Proteins (4) and many more products for this protein.
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complex signaling mechanisms that involve PREX2, PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/PTEN (show PTEN Antibodies) and downstream epigenetic machinery to deregulate expression of key cell cycle regulators
PREX2 was identified as a frequently mutated gene in human melanoma. .. mutation of PREX2 can accelerate human melanoma growth.
The rapid tumor onset observed in this replication attempt, compared to the original study, makes the detection of accelerated tumor growth in PREX2 expressing NRAS (show NRAS Antibodies)(G12D) melanocytes extremely difficult.
Elevated PREX2 protein expression is associated with pathogenesis of hepatocellular carcinoma.
The results of the present study suggested that PREX2a may act as an oncogene (show RAB1A Antibodies) in osteosarcoma via the inhibition of PTEN (show PTEN Antibodies) activity and activation of PI3K (show PIK3CA Antibodies) signaling.
findings identify PREX2 as a mediator of NRAS (show NRAS Antibodies)-mutant melanoma development that acts through the PI3K (show PIK3CA Antibodies)/PTEN (show PTEN Antibodies)/Akt (show AKT1 Antibodies) pathway to regulate gene expression of a cell cycle regulator (show CDKN2A Antibodies)
second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation.
PREX2 mutants are likely selected in cancer to escape PTEN (show PTEN Antibodies)-mediated inhibition of invasion.
CXCL9 (show CXCL9 Antibodies) is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2.
Results demonstrate that miR (show MLXIP Antibodies)-338-3p affects gastric cancer progression through PTEN (show PTEN Antibodies)-AKT (show AKT1 Antibodies) signaling by targeting P-Rex2a in gastric cancer cells
complex signaling mechanisms that involve PREX2, PI3K/AKT (show AKT1 Antibodies)/PTEN (show PTEN Antibodies) and downstream epigenetic machinery to deregulate expression of key cell cycle regulators
P-REX2 PH-domain-mediated inhibition of PTEN (show PTEN Antibodies) has a role in regulating insulin (show INS Antibodies) sensitivity and glucose homeostasis
This study demonistrated that the P-Rex2, a GEF (show ARHGEF2 Antibodies) that specifically activates Rac (show AKT1 Antibodies) small GTPases, is expressed in a cell- and synapse-specific manner in the retina.
PI3K/P-Rex/Rac (show AKT1 Antibodies) pathway is required for late phase long-term potentiation in the mouse cerebellum
P-Rex1 (show PREX1 Antibodies) and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase (By similarity).
DEP domain-containing protein 2
, PtdIns(3,4,5)-dependent Rac exchanger 2
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
, DEP domain containing 2
, ptdIns(3,4,5)-dependent Rac exchanger 2