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May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Additionally we are shipping DET1 and DDB1 Associated 1 Antibodies (44) and many more products for this protein.
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the c-Abl (show ABL1 Proteins) non-receptor kinase phosphorylates DDB1 (show DDB1 Proteins) at residue Tyr (show TYR Proteins)-316 to recruit a small regulatory protein, DDA1, leading to increased substrate ubiquitination
PCIA1 gene expression correlates with tumor formation, invasion and metastasis
Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with cullin-RING E3 ligases complexes.
Data describe the characterization of the testis-specific effects of absence of the high-affinity thiamin transporter, Tht1.
Pancreatic beta cells and islets take up thiamine by a regulated THTR1/2-mediated process.
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD- E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity).
DET1- and DDB1-associated protein 1
, cross-immune reaction antigen PCIA1
, placenta cross-immune reaction antigen 1
, thiamine transporter 1