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DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. Additionally we are shipping DIRAS3 Proteins (5) and many more products for this protein.
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Human Polyclonal DIRAS3 Primary Antibody for ELISA, WB - ABIN563932
Li, Ramani, Sun, Zee, Grant, Yang, Xia, Oh, Ko, Mato, Lu: Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. in The American journal of pathology 2010
polymorphism-based approach was used to detect the imprinting status of NNAT (show NNAT Antibodies) and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids
Transcriptional, but not post-transcriptional, silencing of GNG12-AS1 (show PTGDR Antibodies) causes concomitant upregulation of DIRAS3, indicating a function in transcriptional interference.
ARHI mRNA and protein expression is markedly decreased in osteosarcoma MG-63 cells lines. Overexpression of ARHI inhibits cell viability and proliferation.
ARHI-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.
EZH2 (show EZH2 Antibodies)-''induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in epithelial ovarian cancer
ARHI competes with RanGTPase and interacts with importin beta (show KPNB1 Antibodies) via basic-acidic patch interaction, which leads to inhibition of STAT3 (show STAT3 Antibodies) translocation.
Letter: ARHI suppresses pancreatic cancer by regulating ERK 1 (show MAPK3 Antibodies)/2 signaling.
JMJD2A (show KDM4A Antibodies)-dependent silencing of Sp1 (show PSG1 Antibodies) in advanced breast cancer promotes metastasis by downregulation of DIRAS3.
suggest that DIRAS3 not only regulates the autophagosome initiation complex, but induces autophagy in dormant, nutrient-deprived ovarian cancer cells that remain after conventional chemotherapy, facilitating their survival
ARHI is required for autophagy-meditated cancer cell arrest and ARHI inhibits signaling through PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and Ras/MAP by enhancing internalization and degradation of the epidermal growth factor receptor (show EGFR Antibodies).
The silence of ARHI expression in vitro seems to accelerate the malignant transformation of healthy ovarian cells by restraining apoptosis and autophagy.
This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers.
DIRAS family, GTP-binding RAS-like 3
, GTP-binding protein Di-Ras3
, GTP-binding RAS-like protein 3
, distinct subgroup of the Ras family member 3
, ras homolog gene family, member I
, rho-related GTP-binding protein RhoI