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anti-DIS3 Mitotic Control Homolog (S. Cerevisiae) (DIS3) Antibodies

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. Additionally we are shipping DIS3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DIS3 22894 Q9Y2L1
DIS3 72662 Q9CSH3
DIS3 306103  
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Top anti-DIS3 Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DIS3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB DIS3 Antibody (Center)  western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the DIS3 antibody detected DIS3 protein (arrow). DIS3 antibody (Center)  immunohistochemistry analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the DIS3 antibody (Center) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin fixed and paraffin embedded human testis carcinoma reacted with DIS3 Antibody  followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of DIS3 Antibody  in mouse bladder tissue lysates (15ug/lane). This demonstrates the DIS3 antibody detected DIS3 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.67 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Schizosaccharomyces pombe Rabbit Un-conjugated IF, WB 100 μL Log in to see 7 to 8 Days
$385.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of DIS3 expression in transfected 293T cell line by DIS3 MaxPab polyclonal antibody.Lane 1: KIAA1008 transfected lysate(105.38 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to KIAA1008 on HeLa cell. [antibody concentration 10 ug/ml] 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human, Skin; Formalin-Fixed Paraffin-Embedded (FFPE) 200 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit PE IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

DIS3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Rat (Rattus) ,


Top referenced anti-DIS3 Antibodies

  1. Human Polyclonal DIS3 Primary Antibody for IHC (p), WB - ABIN654155 : Tomecki, Kristiansen, Lykke-Andersen, Chlebowski, Larsen, Szczesny, Drazkowska, Pastula, Andersen, Stepien, Dziembowski, Jensen: The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. in The EMBO journal 2010 (PubMed)
    Show all 3 references for ABIN654155

  2. Schizosaccharomyces pombe Polyclonal DIS3 Primary Antibody for IF, WB - ABIN2451952 : Kinoshita, Goebl, Yanagida: The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control. in Molecular and cellular biology 1991 (PubMed)
    Show all 2 references for ABIN2451952

  3. Human Polyclonal DIS3 Primary Antibody for IF, WB - ABIN524835 : Xie, Li, Vilborg, Lee, Shu, Yartseva, Šestan, Steitz: Mammalian 5'-capped microRNA precursors that generate a single microRNA. in Cell 2013 (PubMed)

  4. Cow (Bovine) Polyclonal DIS3 Primary Antibody for WB - ABIN2779073 : Andersen, Lam, Leung, Ong, Lyon, Lamond, Mann: Nucleolar proteome dynamics. in Nature 2005 (PubMed)

  5. Human Polyclonal DIS3 Primary Antibody for ELISA, WB - ABIN564954 : Niemelä, Oghabian, Staals, Greco, Pruijn, Frilander: Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome. in Nucleic acids research 2014 (PubMed)

More Antibodies against DIS3 Interaction Partners

Human DIS3 Mitotic Control Homolog (S. Cerevisiae) (DIS3) interaction partners

  1. Data indicate the pathological relevance of exosome component 11 protein (DIS3) mutations in plasma cell dyscrasias and suggest that DIS3 may represent a potential tumor suppressor gene in such disorders.

  2. structure and function of DIS3

  3. The study establishes that the ribonuclease DIS3, targeting LIN28B (show LIN28B Antibodies), sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation.

  4. seven novel somatic DIS3 single nucleotide variants (SNVs) and defined three hot spot mutations within the RNB domain.

  5. Overexpression of DIS3 and LRCH1 (show LRCH1 Antibodies) associated with adenoma to carcinoma progression is linked to the colorectal cancer specific gain of 13q.

  6. Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing. Similar to S. cerevisiae Dis3p, human Dis3p enhanced RCC1 (show RCC1 Antibodies)-stimulated nucleotide release from Ran, in a dose-dependent manner, and bound to GTP (show AK3 Antibodies)- or GDP-Ran.

  7. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase (show PNPT1 Antibodies)-like ring. There appears to be no interaction between human dis3 and other exosome subunits, however.

Mouse (Murine) DIS3 Mitotic Control Homolog (S. Cerevisiae) (DIS3) interaction partners

  1. The study establishes that the ribonuclease DIS3, targeting LIN28B (show LIN28B Antibodies), sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation.

DIS3 Antigen Profile

Protein Summary

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities (By similarity).

Gene names and symbols associated with DIS3

  • DIS3 mitotic control homolog (S. cerevisiae) (DIS3) antibody
  • DIS3 mitotic control homolog (S. cerevisiae) (Dis3) antibody
  • 2810028N01Rik antibody
  • bA555G22.1 antibody
  • DIS3 antibody
  • dis3p antibody
  • EXOSC11 antibody
  • KIAA1008 antibody
  • RGD1304646 antibody
  • RP11-342J4.3 antibody
  • RRP44 antibody

Protein level used designations for DIS3

exosome complex exonuclease RRP44 , DIS3 mitotic control homolog (S. cerevisiae) , 2810028N01Rik , exosome component 11 , mitotic control protein dis3 homolog , protein DIS3 homolog , ribosomal RNA-processing protein 44

GENE ID SPECIES
100051938 Equus caballus
452595 Pan troglodytes
694048 Macaca mulatta
22894 Homo sapiens
485491 Canis lupus familiaris
767887 Bos taurus
72662 Mus musculus
306103 Rattus norvegicus
Selected quality suppliers for anti-DIS3 (DIS3) Antibodies
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