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DIS3 Proteins

(Exosome Complex Exonuclease RRP44 (DIS3))

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities (By similarity).

recommended

DIS3 Protein (AA 861-956) (GST tag) (ABIN1351629)

DIS3 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

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recommended

DIS3 Protein (AA 1-958) (Strep Tag) (ABIN3137036)

Crystallography grade DIS3 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

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recommended

DIS3 Protein (AA 1-958) (Strep Tag) (ABIN3095104)

Crystallography grade DIS3 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

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DIS3 Proteins by Grade

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DIS3 Proteins by Origin

Find DIS3 Proteins for a variety of species such as anti-Human DIS3, anti-Mouse DIS3. The species listed below are among those available. Click on a link to go to the corresponding products.

DIS3 Proteins by Source

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DIS3 Proteins by Protein Type

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DIS3 Proteins by Application

Find DIS3 Proteins validated for a specific application such as ELISA, WB, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular DIS3 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

DIS3 Protein (AA 861-956) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1351629

Quantity 10 μg

Datasheet Datasheet

DIS3 Protein (AA 1-958) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3137036

Quantity 1 mg

Datasheet Datasheet

DIS3 Protein (AA 1-958) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3095104

Quantity 1 mg

Datasheet Datasheet

DIS3 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2719499

Quantity 20 μg

Datasheet Datasheet

Aliases for DIS3 Proteins

DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3) Proteins
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (Dis3) Proteins
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease (dis3) Proteins
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (dis3.L) Proteins
2810028N01Rik Proteins
bA555G22.1 Proteins
DIS3 Proteins
dis3 Proteins
dis3p Proteins
EXOSC11 Proteins
KIAA1008 Proteins
RGD1304646 Proteins
RP11-342J4.3 Proteins
RRP44 Proteins
wu:fb08g12 Proteins

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DIS3 Proteins by Grade

DIS3 Proteins by Origin

DIS3 Proteins by Source

DIS3 Proteins by Protein Type

DIS3 Proteins by Application

Popular DIS3 Proteins

Aliases for DIS3 Proteins

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