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The protein encoded by DIXDC1 is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. Additionally we are shipping DIX Domain Containing 1 Antibodies (43) and DIX Domain Containing 1 Kits (3) and many more products for this protein.
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DIXDC1 was overexpressed in gastric cancer and correlated with poor prognosis.
DIXDC1 is associated with stage and prognosis in non-small cell lung cancer, and may promote invasion and migration through PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins)/AP-1 (show FOSB Proteins)-dependent activation of metalloproteinases
DIXDC1 depletion results in upregulation of Snail1 (show SNAI1 Proteins) in a FAK (show PTK2 Proteins)-dependent manner, leading to increased cell invasion. MARK1 (show MARK1 Proteins) phosphorylation of DIXDC1 is required for its localization to focal adhesions and ability to suppress metastasis in mice.
Transgenic DIXDC1 might contribute to pathophysiology underlying abnormal behaviors in sch (show DISC1 Proteins)izophrenia and other major psychiatric disorders in mice.
a molecular mechanism for Ccd1 (show RUNX2 Proteins)-mediated Wnt (show WNT2 Proteins) activation in that Ccd1 (show RUNX2 Proteins) converts latent polymeric Dvl (show DVL2 Proteins) to a biologically active oligomer(s).
This study reveal that Dixdc1 integrates DISC1 (show DISC1 Proteins) into Wnt (show WNT2 Proteins)-GSK3beta/beta-catenin (show CTNNB1 Proteins)-dependent and -independent signaling pathways during cortical development and further delineate how DISC1 (show DISC1 Proteins) contributes to neuropsychiatric disorders.
Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway activation might upregulate DIXDC1 through a post-translational mechanism by inhibiting the ubiquitin-mediated degradation of the DIXDC1 protein.
MTHDIX (KIAA1735) protein consists of Myosine-tail homologous (MTH) domain and C-terminal DIX domain.
Ccd1 (show RUNX2 Proteins) inhibits Axin (show AXIN1 Proteins)-mediated JNK (show MAPK8 Proteins) activation by simultaneously adopting two distinct mechanisms, one through conformational changes that disallow MEKK1 (show MAP3K1 Proteins) binding and the other via direct sequestration of MEKK4 (show MAP3K4 Proteins).
Thus, our data provide the first evidence that l-DIXDC1 may act as a novel branching component in the Wnt signaling pathway targeting both beta-catenin-TCF complex for gene expression and cytoskeleton for regulating dynamics of actin filaments.
Abnormal behavior in Dixdc1 mice could elucidate molecular pathophysiology involving Disc1 (show DISC1 Proteins) in major mental illnesses.
crystals of the Ccd1 DIX domain belonged to space group P2(1)2(1)2(1), with unit-cell parameters a=72.9, b=75.7, c=125.6 A. An X-ray diffraction data set was collected at 3.0 A resolution
a molecular mechanism for Ccd1-mediated Wnt (show WNT2 Proteins) activation in that Ccd1 converts latent polymeric Dvl (show DVL1 Proteins) to a biologically active oligomer(s).
DIXDC1 encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain
mouse Ccd1 functions as a positive regulator of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway. Furthermore, Ccd1 is highly expressed and co-localized with Wnt (show WNT2 Proteins) signaling molecules in the embryonic and adult brain.
These results indicate that Ccd1 is a novel positive regulator in this Wnt (show WNT2 Proteins) signaling pathway during zebrafish neural patterning.
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. The encoded protein is found associated with gamma tubulin at the centrosome. Three transcript variants, two protein-coding and the other non-protein coding, have been found for this gene. The longer isoform also associates with actin stress fibers while the shorter isoform does not.
DIX domain containing 1
, coiled-coil protein DIX1
, DIX domain-containing protein 1
, DIX domain-containing protein 1-A
, coiled-coil DIX 1
, coiled-coil protein DIX1-A