You are viewing an incomplete version of our website. Please click to reload the website as full version.

DIX Domain Containing 1 Proteins (DIXDC1)

The protein encoded by DIXDC1 is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. Additionally we are shipping DIX Domain Containing 1 Antibodies (43) and DIX Domain Containing 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DIXDC1 85458 Q155Q3
DIXDC1 330938 Q80Y83
DIXDC1 363062 Q2VUH7
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top DIX Domain Containing 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,958.17
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details

DIXDC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)
,
Rat (Rattus)

More Proteins for DIX Domain Containing 1 (DIXDC1) Interaction Partners

Human DIX Domain Containing 1 (DIXDC1) interaction partners

  1. DIXDC1 was overexpressed in gastric cancer and correlated with poor prognosis.

  2. DIXDC1 is associated with stage and prognosis in non-small cell lung cancer, and may promote invasion and migration through PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins)/AP-1 (show FOSB Proteins)-dependent activation of metalloproteinases

  3. DIXDC1 depletion results in upregulation of Snail1 (show SNAI1 Proteins) in a FAK (show PTK2 Proteins)-dependent manner, leading to increased cell invasion. MARK1 (show MARK1 Proteins) phosphorylation of DIXDC1 is required for its localization to focal adhesions and ability to suppress metastasis in mice.

  4. Transgenic DIXDC1 might contribute to pathophysiology underlying abnormal behaviors in sch (show DISC1 Proteins)izophrenia and other major psychiatric disorders in mice.

  5. a molecular mechanism for Ccd1 (show RUNX2 Proteins)-mediated Wnt (show WNT2 Proteins) activation in that Ccd1 (show RUNX2 Proteins) converts latent polymeric Dvl (show DVL2 Proteins) to a biologically active oligomer(s).

  6. This study reveal that Dixdc1 integrates DISC1 (show DISC1 Proteins) into Wnt (show WNT2 Proteins)-GSK3beta/beta-catenin (show CTNNB1 Proteins)-dependent and -independent signaling pathways during cortical development and further delineate how DISC1 (show DISC1 Proteins) contributes to neuropsychiatric disorders.

  7. Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway activation might upregulate DIXDC1 through a post-translational mechanism by inhibiting the ubiquitin-mediated degradation of the DIXDC1 protein.

  8. MTHDIX (KIAA1735) protein consists of Myosine-tail homologous (MTH) domain and C-terminal DIX domain.

  9. Ccd1 (show RUNX2 Proteins) inhibits Axin (show AXIN1 Proteins)-mediated JNK (show MAPK8 Proteins) activation by simultaneously adopting two distinct mechanisms, one through conformational changes that disallow MEKK1 (show MAP3K1 Proteins) binding and the other via direct sequestration of MEKK4 (show MAP3K4 Proteins).

  10. Thus, our data provide the first evidence that l-DIXDC1 may act as a novel branching component in the Wnt signaling pathway targeting both beta-catenin-TCF complex for gene expression and cytoskeleton for regulating dynamics of actin filaments.

Mouse (Murine) DIX Domain Containing 1 (DIXDC1) interaction partners

  1. Abnormal behavior in Dixdc1 mice could elucidate molecular pathophysiology involving Disc1 (show DISC1 Proteins) in major mental illnesses.

  2. crystals of the Ccd1 DIX domain belonged to space group P2(1)2(1)2(1), with unit-cell parameters a=72.9, b=75.7, c=125.6 A. An X-ray diffraction data set was collected at 3.0 A resolution

  3. a molecular mechanism for Ccd1-mediated Wnt (show WNT2 Proteins) activation in that Ccd1 converts latent polymeric Dvl (show DVL1 Proteins) to a biologically active oligomer(s).

  4. DIXDC1 encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain

  5. mouse Ccd1 functions as a positive regulator of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway. Furthermore, Ccd1 is highly expressed and co-localized with Wnt (show WNT2 Proteins) signaling molecules in the embryonic and adult brain.

Zebrafish DIX Domain Containing 1 (DIXDC1) interaction partners

  1. These results indicate that Ccd1 is a novel positive regulator in this Wnt (show WNT2 Proteins) signaling pathway during zebrafish neural patterning.

DIX Domain Containing 1 (DIXDC1) Protein Profile

Protein Summary

The protein encoded by this gene is a positive regulator of the Wnt signaling pathway and interacts with AXIN1, DVL2, and MAP3K1. The encoded protein is found associated with gamma tubulin at the centrosome. Three transcript variants, two protein-coding and the other non-protein coding, have been found for this gene. The longer isoform also associates with actin stress fibers while the shorter isoform does not.

Gene names and symbols associated with DIXDC1

  • DIX domain containing 1 (DIXDC1)
  • DIX domain containing 1 (dixdc1)
  • DIX domain containing 1 (Dixdc1)
  • DIX domain containing 1a (dixdc1a)
  • DIX domain containing 1b (dixdc1b)
  • 4930563F16Rik protein
  • BC048182 protein
  • ccd1 protein
  • Ccd1Aalpha1L protein
  • Ccd1Abeta1L protein
  • Ccd1BalphaL protein
  • Ccd1BbetaL protein
  • Ccd1CL protein
  • dixdc1 protein
  • im:7138279 protein
  • mKIAA1735 protein

Protein level used designations for DIXDC1

DIX domain containing 1 , dixin-like , coiled-coil protein DIX1 , dixin , DIX domain-containing protein 1 , coiled-coil-DIX1 , DIX domain-containing protein 1-A , coiled-coil DIX 1 , coiled-coil protein DIX1-A , coiled-coil-DIX1-A , dixin-A

GENE ID SPECIES
419798 Gallus gallus
466779 Pan troglodytes
710847 Macaca mulatta
100032288 Monodelphis domestica
100061990 Equus caballus
100225366 Taeniopygia guttata
100349631 Oryctolagus cuniculus
100411324 Callithrix jacchus
100462633 Pongo abelii
100497786 Xenopus (Silurana) tropicalis
100548570 Meleagris gallopavo
100581393 Nomascus leucogenys
85458 Homo sapiens
608957 Canis lupus familiaris
541211 Bos taurus
330938 Mus musculus
363062 Rattus norvegicus
360137 Danio rerio
794716 Danio rerio
Selected quality suppliers for DIX Domain Containing 1 Proteins (DIXDC1)
Did you look for something else?