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The protein encoded by DMC1 is essential for meiotic homologous recombination. Additionally we are shipping DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) Antibodies (128) and DMC1 Dosage Suppressor of Mck1 Homolog, Meiosis-Specific Homologous Recombination (Yeast) Kits (3) and many more products for this protein.
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The DMC1 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 (show MLH1 Proteins) showed little variability.
RAD51AP1 (show RAD51AP1 Proteins) foci colocalize with a subset of DMC1 foci in spermatocytes.
p53 (show TP53 Proteins) might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells
TBPIP/HOP2 (show PSMC3IP Proteins) directly binds to DNA and functions as an activator for DMC1 during the homologous pairing step in meiosis
data reveal an interplay among Hop2 (show PSMC3IP Proteins), Mnd1 (show MND1 Proteins) and Rad51 (show RAD51 Proteins) and Dmc1 in the formation of the first recombination intermediates during meiosis
Mei1 (show MEI1 Proteins) can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis
Dmc1(Mei11) exposes a sex difference in recombination in that a significant portion of female oocytes can compensate for DMC1 deficiency to undergo crossing-over and complete gametogenesis.
Data indicate that ahomologous pairing by DMC1 protein or RAD51 (show RAD51 Proteins) recombinase (show RAG1 Proteins) in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions.
BRCA2 (show BRCA2 Proteins) protein stimulates DMC1-mediated DNA strand exchange between RPA (show RPA1 Proteins)-ssDNA complexes and duplex DNA, thus identifying BRCA2 (show BRCA2 Proteins) as a mediator of DMC1 recombination function.
Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence.
In contrast to RAD51 (show RAD51 Proteins), stabilization of the presynaptic filament via ATP hydrolysis attenuation is insufficient for enhancement of the DMC1-catalyzed recombination reaction.
truncated DMC1 octamers further stack with alternate polarity into a filament
results suggested mutations in the coding sequence of DMC1 are not associated with premature ovarian failure in Chinese women
The results suggested that PSF (show IGFBP7 Proteins) may function as an activator for the meiosis-specific recombinase (show RAG1 Proteins) DMC1.
RAD51-associated protein 1 (RAD51AP1 (show RAD51AP1 Proteins)) interacts with the meiotic recombinase (show RAG1 Proteins) DMC1 through a conserved motif.
D-loops in a human DMC1-driven reaction are substantially more resistant to dissociation by branch-migration proteins such as RAD54 (show ATRX Proteins) than those formed by RAD51 (show RAD51 Proteins).
The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined.
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
, RecA homolog Dmc1
, disrupted meiotic cDNA 1
, meiotic recombination protein DMC1/LIM15 homolog
, meiotic recombination protein DMC1/LIM15 homolog-like
, meiotic recombination protein dmc1/lim15-like protein
, disrupted meiotic cDNA 1 homolog
, DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
, disrupted meiotic cDNA1, yeast, homolog of