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anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) Antibodies

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNA (Cytosine-5-)-Methyltransferase 3 Like Proteins (10) and DNA (Cytosine-5-)-Methyltransferase 3 Like Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TRDMT1 445264  
TRDMT1 29947 Q9UJW3
TRDMT1 309680 Q1LZ50
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Top anti-DNA (Cytosine-5-)-Methyltransferase 3 Like Antibodies at antibodies-online.com

Showing 10 out of 162 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Mouse Dnmt3L Antibody (ABIN387907) in Hela cell line lysates (35 µg/lane). Dnmt3l (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DNMT3L Antibody (C-term) in Jurkat cell line lysates (35ug/lane). This demonstrates the DNMT3L antibody detected the DNMT3L protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Dnmt3L-R322 (ABIN387892) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the DNMT3L antibody detected the DNMT3L protein (arrow). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICC, IF, IP, IHC, WB SMC 341DNMT3LRat Tissue Mix Western Blotting. 100 μg Log in to see 3 to 4 Days
$383.90
Details
Human Rabbit Un-conjugated EIA, IP, WB Immunoblotting. Affinity Purified Rabbit anti-DNMT3L was used at a 1:1,500 dilution to detect human DNMT3L by western blot after immuno-precipitation using the same antibody. Transfection of U2OS cells (10cm dish) was accomplished using 3 ug of GAL4-DNMT3L. Protein extraction using IPH at 150mM. For IP and WB conditions see Fuks et al.(2000). For western blotting the antibody was used at 0.4ug/ml in TBS milk 2%, BSA 0.5%. Detection occurred using ECL. Note: this antibody works for western blotting only following immunoprecipitation. We have not had good success using the antibody directly for western blotting. The expected molecular weight of human DNMT3L is 43.6 kDa. Schematic representation of the Dnmt3 family members. The conserved N-terminal cysteine-rich region, the PHD-like motif, characteristic of the Dnmt3 family is shown. The C-terminal domain is the catalytic methyltransferase domain present in Dnmt3a and Dnmt3b whereas the key catalytic motifs are absent in Dnmt3L. Numbers indicate amino acid residues. 0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse HRP ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$422.40
Details
Human Mouse FITC ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) ICC, IF, IP, IHC, WB   100 μg Log in to see 3 to 4 Days
$429.00
Details

TRDMT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DNA (Cytosine-5-)-Methyltransferase 3 Like Antibodies

  1. Human Polyclonal TRDMT1 Primary Antibody for EIA, IP - ABIN118012 : Liu, Shen, Zhu, Cui, Gou: In vitro cytotoxicity study on platinum (II) complexes with epoxysuccinates as leaving groups. in Bioorganic & medicinal chemistry letters 2007 (PubMed)
    Show all 11 references for ABIN118012

  2. Human Monoclonal TRDMT1 Primary Antibody for ICC, IF - ABIN863134 : Bestor, Laudano, Mattaliano, Ingram: Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. in Journal of molecular biology 1989 (PubMed)
    Show all 8 references for ABIN863134

  3. Human Polyclonal TRDMT1 Primary Antibody for EIA, IHC (p) - ABIN356577 : Kierszenbaum: Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths. in Molecular reproduction and development 2002 (PubMed)
    Show all 5 references for ABIN356577

  4. Human Monoclonal TRDMT1 Primary Antibody for ICC, IF - ABIN2482691 : Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999 (PubMed)
    Show all 3 references for ABIN2482691

  5. Human Monoclonal TRDMT1 Primary Antibody for ICC, IF - ABIN2482687 : Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999 (PubMed)
    Show all 3 references for ABIN2482687

  6. Human Monoclonal TRDMT1 Primary Antibody for ICC, IF - ABIN2482690 : Reik, Kelsey, Walter: Dissecting de novo methylation. in Nature genetics 1999 (PubMed)
    Show all 3 references for ABIN2482690

  7. Human Polyclonal TRDMT1 Primary Antibody for IHC (p), WB - ABIN387892 : Chedin, Lieber, Hsieh: The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 references for ABIN387892

  8. Human Polyclonal TRDMT1 Primary Antibody for EIA, WB - ABIN356591 : Okazaki, Furuno, Kasukawa, Adachi, Bono, Kondo, Nikaido, Osato, Saito, Suzuki, Yamanaka, Kiyosawa, Yagi, Tomaru, Hasegawa, Nogami, Schönbach, Gojobori, Baldarelli, Hill, Bult, Hume, Quackenbush et al.: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. ... in Nature 2002 (PubMed)
    Show all 3 references for ABIN356591

  9. Human Polyclonal TRDMT1 Primary Antibody for WB - ABIN387907 : Bourchis, Xu, Lin, Bollman, Bestor: Dnmt3L and the establishment of maternal genomic imprints. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 2 references for ABIN387907

  10. Human Polyclonal TRDMT1 Primary Antibody for EIA, WB - ABIN951958 : Manderwad, Gokul, Kannabiran, Honavar, Khosla, Vemuganti: Hypomethylation of the DNMT3L promoter in ocular surface squamous neoplasia. in Archives of pathology & laboratory medicine 2010 (PubMed)
    Show all 2 references for ABIN951958

More Antibodies against DNA (Cytosine-5-)-Methyltransferase 3 Like Interaction Partners

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. Dnmt3l-KO donor cells may offer a more permissive epigenetic state that is beneficial for Nuclear transfer reprogramming

  2. By interacting with TRIM28 (show TRIM28 Antibodies), DNMT3L can attract various enzymes to form a DNMT3L-induced repressive complex to remove active marks and add repressive marks to histone proteins.

  3. Hypomethylation of highly methylated CpG islands was caused by the downregulation of Dnmt3L and Dnmt3a (show DNMT3A Antibodies) due to hepatitis B X-protein bound to their promoters.

  4. DNMT3L is required to delicately balance the cycling and quiescence of spermatogonial progenitor cells

  5. Study demonstrates that Dnmt3L interacts with the Polycomb (show CBX2 Antibodies) PRC2 complex in competition with the DNA methyltransferases Dnmt3a (show DNMT3A Antibodies) and Dnmt3b (show DNMT3B Antibodies) to maintain low methylation levels at the Histone 3 H3K27me3 regions.

  6. Data indicate that expression of Dnmt3a (show DNMT3A Antibodies), Dnmt3b (show DNMT3B Antibodies), Dnmt3L as well as maintenance Dnmt1o (show DNMT1 Antibodies) in oocytes and zygotes was not disrupted.

  7. Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells.

  8. The maternal store of Dnmt3L is not involved in embryonic de novo methylation.

  9. Dnmt3l is one of the key players in de novo DNA methylation (show HELLS Antibodies) of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)

  10. We observe evidence for a context-dependent contribution of Dnmt3l to set and maintain CpG and non-CpG methylation at distinct classes of repetitive elements and selected single copy genes

Human DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.

  2. DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history.

  3. crystal structures of DNMT3A (show DNMT3A Antibodies)-DNMT3L (autoinhibitory form) and DNMT3A (show DNMT3A Antibodies)-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively

  4. DNMT3L can address DNMT3A (show DNMT3A Antibodies)/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A (show DNMT3A Antibodies)/B

  5. CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX (show VAC14 Antibodies) response element

  6. DNMT3L is one of the key players in de novo DNA methylation (show HELLS Antibodies) of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)

  7. SNP rs2070565, as well as haplotypes AAA (show APP Antibodies) and GAA (show GAA Antibodies), may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans

  8. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis.

  9. mutation analysis of SYCP3 (show SYCP3 Antibodies), DNMT3L and MSH4 (show MSH4 Antibodies) in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.

  10. This study offers insights into the manner by which DNA methylation (show HELLS Antibodies) patterns are deposited and reveals a new level of interplay between members of the de novo DNMT (show DNMT1 Antibodies) family.

DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) Antigen Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TRDMT1

  • DNA methyltransferase 3-like, pseudogene 1 (Dnmt3l-ps1) antibody
  • DNA (cytosine-5-)-methyltransferase 3-like (DNMT3L) antibody
  • DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l) antibody
  • D6Ertd14e antibody
  • DNMT3L antibody
  • ecat7 antibody

Protein level used designations for TRDMT1

DNA (cytosine-5-)-methyltransferase 3-like , cytosine-5-methyltransferase 3-like protein , DNA (cytosine-5)-methyltransferase 3-like , human cytosine-5-methyltransferase 3-like protein

GENE ID SPECIES
445264 Mus musculus
470099 Pan troglodytes
608536 Canis lupus familiaris
613785 Bos taurus
100050680 Equus caballus
29947 Homo sapiens
54427 Mus musculus
309680 Rattus norvegicus
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