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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNA (Cytosine-5-)-Methyltransferase 3 Like Proteins (10) and DNA (Cytosine-5-)-Methyltransferase 3 Like Kits (1) and many more products for this protein.
Showing 10 out of 165 products:
Human Polyclonal TRDMT1 Primary Antibody for EIA, IP - ABIN118012
Liu, Shen, Zhu, Cui, Gou: In vitro cytotoxicity study on platinum (II) complexes with epoxysuccinates as leaving groups. in Bioorganic & medicinal chemistry letters 2007
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Human Monoclonal TRDMT1 Primary Antibody for ICC, IF - ABIN863134
Bestor, Laudano, Mattaliano, Ingram: Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. in Journal of molecular biology 1989
Show all 8 references for ABIN863134
Human Polyclonal TRDMT1 Primary Antibody for EIA, IHC (p) - ABIN356577
Kierszenbaum: Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths. in Molecular reproduction and development 2002
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Human Monoclonal TRDMT1 Primary Antibody for ICC, IF - ABIN2482690
Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999
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Human Monoclonal TRDMT1 Primary Antibody for ICC, IF - ABIN2482687
Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999
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Human Monoclonal TRDMT1 Primary Antibody for ICC, IF - ABIN2482691
Reik, Kelsey, Walter: Dissecting de novo methylation. in Nature genetics 1999
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Human Polyclonal TRDMT1 Primary Antibody for IHC (p), WB - ABIN387892
Chedin, Lieber, Hsieh: The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Polyclonal TRDMT1 Primary Antibody for EIA, WB - ABIN356591
Okazaki, Furuno, Kasukawa, Adachi, Bono, Kondo, Nikaido, Osato, Saito, Suzuki, Yamanaka, Kiyosawa, Yagi, Tomaru, Hasegawa, Nogami, Schönbach, Gojobori, Baldarelli, Hill, Bult, Hume, Quackenbush et al.: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. ... in Nature 2002
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Human Polyclonal TRDMT1 Primary Antibody for WB - ABIN387907
Bourchis, Xu, Lin, Bollman, Bestor: Dnmt3L and the establishment of maternal genomic imprints. in Science (New York, N.Y.) 2001
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Human Polyclonal TRDMT1 Primary Antibody for EIA, WB - ABIN951958
Manderwad, Gokul, Kannabiran, Honavar, Khosla, Vemuganti: Hypomethylation of the DNMT3L promoter in ocular surface squamous neoplasia. in Archives of pathology & laboratory medicine 2010
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Dnmt3l-KO donor cells may offer a more permissive epigenetic state that is beneficial for Nuclear transfer reprogramming
By interacting with TRIM28 (show TRIM28 Antibodies), DNMT3L can attract various enzymes to form a DNMT3L-induced repressive complex to remove active marks and add repressive marks to histone proteins.
Hypomethylation of highly methylated CpG islands was caused by the downregulation of Dnmt3L and Dnmt3a (show DNMT3A Antibodies) due to hepatitis B X-protein bound to their promoters.
DNMT3L is required to delicately balance the cycling and quiescence of spermatogonial progenitor cells
Study demonstrates that Dnmt3L interacts with the Polycomb (show CBX2 Antibodies) PRC2 complex in competition with the DNA methyltransferases Dnmt3a (show DNMT3A Antibodies) and Dnmt3b (show DNMT3B Antibodies) to maintain low methylation levels at the Histone 3 H3K27me3 regions.
Data indicate that expression of Dnmt3a (show DNMT3A Antibodies), Dnmt3b (show DNMT3B Antibodies), Dnmt3L as well as maintenance Dnmt1o (show DNMT1 Antibodies) in oocytes and zygotes was not disrupted.
Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells.
The maternal store of Dnmt3L is not involved in embryonic de novo methylation.
Dnmt3l is one of the key players in de novo DNA methylation (show HELLS Antibodies) of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)
We observe evidence for a context-dependent contribution of Dnmt3l to set and maintain CpG and non-CpG methylation at distinct classes of repetitive elements and selected single copy genes
the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.
DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history.
crystal structures of DNMT3A (show DNMT3A Antibodies)-DNMT3L (autoinhibitory form) and DNMT3A (show DNMT3A Antibodies)-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively
DNMT3L can address DNMT3A (show DNMT3A Antibodies)/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A (show DNMT3A Antibodies)/B
CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX (show VAC14 Antibodies) response element
DNMT3L is one of the key players in de novo DNA methylation (show HELLS Antibodies) of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)
SNP rs2070565, as well as haplotypes AAA (show APP Antibodies) and GAA (show GAA Antibodies), may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans
Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis.
mutation analysis of SYCP3 (show SYCP3 Antibodies), DNMT3L and MSH4 (show MSH4 Antibodies) in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.
This study offers insights into the manner by which DNA methylation (show HELLS Antibodies) patterns are deposited and reveals a new level of interplay between members of the de novo DNMT (show DNMT1 Antibodies) family.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5-)-methyltransferase 3-like
, cytosine-5-methyltransferase 3-like protein
, DNA (cytosine-5)-methyltransferase 3-like
, human cytosine-5-methyltransferase 3-like protein