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DNA (Cytosine-5-)-Methyltransferase 3 Like Proteins (TRDMT1)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNA (Cytosine-5-)-Methyltransferase 3 Like Antibodies (162) and DNA (Cytosine-5-)-Methyltransferase 3 Like Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRDMT1 445264  
TRDMT1 29947 Q9UJW3
TRDMT1 309680 Q1LZ50
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Top DNA (Cytosine-5-)-Methyltransferase 3 Like Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,175.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TRDMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , , ,
,
Rat (Rattus)

More Proteins for DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) Interaction Partners

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. Dnmt3l-KO donor cells may offer a more permissive epigenetic state that is beneficial for Nuclear transfer reprogramming

  2. By interacting with TRIM28 (show TRIM28 Proteins), DNMT3L can attract various enzymes to form a DNMT3L-induced repressive complex to remove active marks and add repressive marks to histone proteins.

  3. Hypomethylation of highly methylated CpG islands was caused by the downregulation of Dnmt3L and Dnmt3a (show DNMT3A Proteins) due to hepatitis B X-protein bound to their promoters.

  4. DNMT3L is required to delicately balance the cycling and quiescence of spermatogonial progenitor cells

  5. Study demonstrates that Dnmt3L interacts with the Polycomb (show CBX2 Proteins) PRC2 complex in competition with the DNA methyltransferases Dnmt3a (show DNMT3A Proteins) and Dnmt3b (show DNMT3B Proteins) to maintain low methylation levels at the Histone 3 H3K27me3 regions.

  6. Data indicate that expression of Dnmt3a (show DNMT3A Proteins), Dnmt3b (show DNMT3B Proteins), Dnmt3L as well as maintenance Dnmt1o (show DNMT1 Proteins) in oocytes and zygotes was not disrupted.

  7. Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells.

  8. The maternal store of Dnmt3L is not involved in embryonic de novo methylation.

  9. Dnmt3l is one of the key players in de novo DNA methylation (show HELLS Proteins) of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)

  10. We observe evidence for a context-dependent contribution of Dnmt3l to set and maintain CpG and non-CpG methylation at distinct classes of repetitive elements and selected single copy genes

Human DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.

  2. DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history.

  3. crystal structures of DNMT3A (show DNMT3A Proteins)-DNMT3L (autoinhibitory form) and DNMT3A (show DNMT3A Proteins)-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively

  4. DNMT3L can address DNMT3A (show DNMT3A Proteins)/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A (show DNMT3A Proteins)/B

  5. CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX (show VAC14 Proteins) response element

  6. DNMT3L is one of the key players in de novo DNA methylation (show HELLS Proteins) of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)

  7. SNP rs2070565, as well as haplotypes AAA (show APP Proteins) and GAA (show GAA Proteins), may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans

  8. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis.

  9. mutation analysis of SYCP3 (show SYCP3 Proteins), DNMT3L and MSH4 (show MSH4 Proteins) in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.

  10. This study offers insights into the manner by which DNA methylation (show HELLS Proteins) patterns are deposited and reveals a new level of interplay between members of the de novo DNMT (show DNMT1 Proteins) family.

DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) Protein Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TRDMT1

  • DNA methyltransferase 3-like, pseudogene 1 (Dnmt3l-ps1)
  • DNA (cytosine-5-)-methyltransferase 3-like (DNMT3L)
  • DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l)
  • D6Ertd14e protein
  • DNMT3L protein
  • ecat7 protein

Protein level used designations for TRDMT1

DNA (cytosine-5-)-methyltransferase 3-like , cytosine-5-methyltransferase 3-like protein , DNA (cytosine-5)-methyltransferase 3-like , human cytosine-5-methyltransferase 3-like protein

GENE ID SPECIES
445264 Mus musculus
470099 Pan troglodytes
608536 Canis lupus familiaris
613785 Bos taurus
100050680 Equus caballus
29947 Homo sapiens
54427 Mus musculus
309680 Rattus norvegicus
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