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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Kits (28) and DNA (Cytosine-5)-Methyltransferase 1 Proteins (8) and many more products for this protein.
Showing 10 out of 489 products:
Human Monoclonal DNMT1 Primary Antibody for ChIP, CyTOF - ABIN252481
Dennis, Fan, Geiman, Yan, Muegge: Lsh, a member of the SNF2 family, is required for genome-wide methylation. in Genes & development 2001
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Human Polyclonal DNMT1 Primary Antibody for ICC, IF - ABIN151732
Neumeister, Albanese, Balent, Greally, Pestell: Senescence and epigenetic dysregulation in cancer. in The international journal of biochemistry & cell biology 2002
Show all 26 Pubmed References
Human Monoclonal DNMT1 Primary Antibody for IF, WB - ABIN968896
Robertson, Ait-Si-Ali, Yokochi, Wade, Jones, Wolffe: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. in Nature genetics 2000
Show all 4 Pubmed References
Human Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN2668504
Schnekenburger, Talaska, Puga: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. in Molecular and cellular biology 2007
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Human Monoclonal DNMT1 Primary Antibody for IF, WB - ABIN968895
Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999
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Human Polyclonal DNMT1 Primary Antibody for DB, ELISA - ABIN4369817
Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003
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Human Polyclonal DNMT1 Primary Antibody for IHC (p), IHC - ABIN314281
Nanduri, Makarenko, Reddy, Yuan, Pawar, Wang, Khan, Zhang, Kinsman, Peng, Kumar, Fox, Godley, Semenza, Prabhakar: Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 2012
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Human Polyclonal DNMT1 Primary Antibody for FACS, WB - ABIN387878
Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003
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Human Polyclonal DNMT1 Primary Antibody for WB - ABIN387879
Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003
Show all 7 Pubmed References
Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358462
Liao, Siu, Chan, Wong, Ngan, Chan, Li, Khoo, Cheung: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. in International journal of cancer. Journal international du cancer 2008
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Dnmt1 stability requires UHRF1 (show UHRF1 Antibodies) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (show HELLS Antibodies) Is Essential for Maintaining Global DNA Methylation (show HELLS Antibodies) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Antibodies) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (show UHRF1 Antibodies) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Antibodies) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Antibodies) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
Data show that silencing DNA methyltransferase 1 (DNMT1) increased expression of tumor suppressor genes, RASSF1A (show RASSF1 Antibodies) and DAPK (show DAPK1 Antibodies), in esophageal squamous cell carcinoma (ESCC) cells and ESCC xenograft in nude mice.
DNMT1, DNMT3A (show DNMT3A Antibodies), and DNMT3B (show DNMT3B Antibodies) were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 A201G gene polymorphi
H19 (show NCKAP1 Antibodies) promoted proliferation and invasion of breast cancer through the miR (show MLXIP Antibodies)-152/DNMT1 axis, providing a novel mechanism about the occurrence and development of breast cancer.
Placental DNMT1 expression was found to be associated positively with placental weight and birth weight, specifically in the female appropriate for gestational age births.
Variability in placental telomere length is associated with alterations in DNAm at TERT (show TERT Antibodies), DNMT1, and DNMT3a (show DNMT3A Antibodies).
the regulatory and functional interplay between DNA methylation (show HELLS Antibodies) and tyrosine kinase (show TXK Antibodies) signaling in propelling tumorigenesis, providing a widely applicable approach for targeting lung cancer.
Dnmt1 and Dnmt3a (show DNMT3A Antibodies) are critical regulators for epigenetic silencing of endothelial cell marker genes.
malignant proliferation without differentiation, also referred to as cancer "stem" cell self-renewal, hinges on druggable corepressors. Inhibiting these corepressors (e.g., DNMT1) releases p53 (show TP53 Antibodies)-independent terminal differentiation in cancer stem cells but preserves self-renewal of normal stem cells that express stem cell transcription factors
Study demonstrated that the lncRNA H19 (show NCKAP1 Antibodies) promoted LSCC progression via miR (show MLXIP Antibodies)-148a-3p and DNMT1.
DNMT1 up-regulation induced by IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) signaling was indispensable for IL-6 (show IL6 Antibodies)-mediated hepaCAM (show HEPACAM Antibodies) loss in renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)) cell lines ACHN (show LARP6 Antibodies) and 769-P, while DNMT3b (show DNMT3B Antibodies) up-regulation was crucial for hepaCAM (show HEPACAM Antibodies) loss in A498.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (show NLRP5 Antibodies) cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (show MYLIP Antibodies)-29b promoter, up-regulated miR (show MYLIP Antibodies)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (show MYLIP Antibodies)-152 reduced Global DNA methylation (show HELLS Antibodies) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Antibodies) and Ppar gamma (show PPARG Antibodies).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Antibodies) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Antibodies), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (show VIM Antibodies) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Antibodies) and histone modification status in collaboration with MET1
VIM (show VIM Antibodies) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Antibodies) pathway.
Genetic studies indicate that the Polycomb (show CBX2 Antibodies) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (show HELLS Antibodies) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (show HELLS Antibodies) but ectopic hypermethylation of genes previously marked by H3K27m3.
An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.
Data from studies using mouse embryonic fibroblasts suggest that cell proliferation rate positively correlates with expression of Dnmt1 in G1 phase; global DNA methylation (show HELLS Antibodies) is significantly higher in G1 phase than in G2/M phase; larger methylation differences are observed on promoters of pluripotency-related genes; thus, high cell proliferation rates promote generation of induced pluripotent stem cells.
Dnmt1 and Ezh2 (show EZH2 Antibodies) play distinct roles in the different islet cell types
we extended this work by using a biotinylation tagging approach to characterize DNMT1 protein complexes in mouse erythroleukemic cells. We identified novel DNMT1 interactions with several hematopoietic transcription factors with essential roles in erythroid differentiation
The lack of Sirt7 (show SIRT7 Antibodies) is associated with reduced recruitment of DNMT1 and Sirt1 (show SIRT1 Antibodies) at rRNA genes leading to hyperacetylation of histones, reduced DNA methylation (show HELLS Antibodies), fragmentation of the nucleolar structure and loss of rDNA repeats leading to anincreased spontaneous immortalization of primary mouse embryonic fibroblasts.
The lethal Ogden syndrome-associated mutation of Naa10p disrupts its binding to the imprinting control region of H19 (show NCKAP1 Antibodies) and Dnmt1 recruitment.
The T1505 is crucial on the DNA methylation (show HELLS Antibodies) activity of DNMT1 through stabilizing its structure during ongoing round of DNA methylation (show HELLS Antibodies).
During neurogenesis, cortical neurons became protected from S-phase Chk1 (show CHEK1 Antibodies) pathway activation by the DNA methyltransferase Dnmt1, and underwent cell death after S-phase progression.
reciprocal regulation between miR (show MLXIP Antibodies)-148a/152 and DNMT1 in foam cells
indispensable role of DNMT1-mediated epigenetic regulation in postnatal liver growth and regeneration
SETDB1 (show SETDB1 Antibodies) maintains silencing of intracisternal A particle, but in the absence of DNMT1, prolonged binding of NP95 (show UHRF1 Antibodies) to hemimethylated DNA transiently disrupts SETDB1 (show SETDB1 Antibodies)-dependent H3K9me3 deposition.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI