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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3B Kits (11) and DNMT3B Proteins (6) and many more products for this protein.
Showing 10 out of 132 products:
Human Monoclonal DNMT3B Primary Antibody for ChIP, CyTOF - ABIN252478
Santoro, Li, Grummt: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. in Nature genetics 2002
Show all 97 Pubmed References
Human Polyclonal DNMT3B Primary Antibody for ICC, IF - ABIN151734
Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003
Show all 16 Pubmed References
Human Polyclonal DNMT3B Primary Antibody for IHC (p), WB - ABIN387884
Lu, Markowetz, Unwin, Leek, Airoldi, MacArthur, Lachmann, Rozov, Maayan, Boyer, Troyanskaya, Whetton, Lemischka: Systems-level dynamic analyses of fate change in murine embryonic stem cells. in Nature 2009
Show all 13 Pubmed References
Human Polyclonal DNMT3B Primary Antibody for ChIP, IHC - ABIN152675
Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999
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Human Monoclonal DNMT3B Primary Antibody for ChIP, WB - ABIN2668954
Castro, Breiling, Luetkenhaus, Ceteci, Hausmann, Kress, Lyko, Rudel, Rapp: MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma. in Molecular cancer research : MCR 2013
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Human Polyclonal DNMT3B Primary Antibody for IF (p), IHC (p) - ABIN727623
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
Show all 2 Pubmed References
Human Polyclonal DNMT3B Primary Antibody for ICC, IF - ABIN314552
Fűri, Sipos, Spisák, Kiszner, Wichmann, Schöller, Tulassay, Műzes, Molnár: Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status. in TheScientificWorldJournal 2014
Human Monoclonal DNMT3B Primary Antibody for WB - ABIN2668953
Felle, Joppien, Németh, Diermeier, Thalhammer, Dobner, Kremmer, Kappler, Längst: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. in Nucleic acids research 2011
Mouse (Murine) Polyclonal DNMT3B Primary Antibody for WB - ABIN2668253
Ajj, Chesnel, Pinel, Plenat, Flament, Dumond: An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism. in PLoS ONE 2013
dnmt7 specifically methylates no tail gene in the genome
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.
Definitive diagnosis should be done using metaphase analysis to identify centromeric instability and/or ICF disease gene mutations analysis. Bilateral VUR may occur in ICF patients with homozygous DNMT3B mutations in early childhood. Renal ultrasonography should be included in ICF1 patients for the screening of congenital anomalies.
DNMT 3B was upregulated in invasive subclones and exerted on influence of E-cad gene methylation.
Transduction of miR (show MLXIP Antibodies)-339 and miR (show MLXIP Antibodies)-766 expressing viruses into colon cancer cell lines (SW480 and HCT116) decreased DNMT3B expression (1.5, 3-fold) and (3, 4-fold), respectively. In addition, DNA methylation (show HELLS Antibodies) of some tumor suppressor genes decreased.
Immunodeficiency, centromere instability and facial anomalies syndrome specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing.
nickel exposure results in DNMT3b induction and MEG3 (show FAM129B Antibodies) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (show JUN Antibodies) and in turn increasing c-Jun (show JUN Antibodies) inhibition of PHLPP1 (show PHLPP1 Antibodies) transcription, leading to the Akt (show AKT1 Antibodies)/p70S6K (show RPS6KB1 Antibodies)/S6 axis activation, and HIF-1alpha (show HIF1A Antibodies) protein translation, as well as malignant transformation of human bronchial epithelial cells.
Overexpression of MAEL (show MAEL Antibodies) in UCB cells substantially enhanced the enrichment of DNA methyltrans-ferase (DNMT (show DNMT1 Antibodies))3B and histone deacetylase (HDAC)1 (show HDAC1 Antibodies)/2 on the promoter of the MTSS1 (show MTSS1 Antibodies), and thereby epigenetically suppressing the MTSS1 (show MTSS1 Antibodies) transcription.
Data suggest that the overexpression of DNMT3B4 may play an important role in human kidney tumorigenesis through chromosomal instability and methylation of RASSF1A (show RASSF1 Antibodies).
MUC1 (show MUC1 Antibodies)-C is of functional importance to induction of DNMT1 (show DNMT1 Antibodies) and DNMT3b and, in turn, changes in DNA methylation (show HELLS Antibodies) patterns in cancer cells.
Dnmt3b plays a tumor suppressive role in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) AML (show RUNX1 Antibodies) progression
Studies indicate that DNA methylation (show HELLS Antibodies) is mediated by three DNA (Cytosine-5-)-Methyltransferase (DNMTs): DNMT1 (show DNMT1 Antibodies) is responsible for the maintenance of methylation patterns after DNA replication whereas DNMT3A (show DNMT3A Antibodies) and DNMT3B carry out de novo methylation, and DNMT (show DNMT1 Antibodies) inhibitors have showed promising results in clinical trials of prostate cancer.
The epiblast expressed epithelial markers, MUC1 (show MUC1 Antibodies) and E-CADHERIN (show CDH1 Antibodies), and the pluripotency markers, DNMT3B and CRIPTO (show TDGF1 Antibodies).
Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.
The expression levels of DNMT3a (show DNMT3A Antibodies) and DNMT3b were associated with several beef quality traits.
a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation.
Together, this study described the regulation of Chk2 (show CHEK2 Antibodies) expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 (show CHEK2 Antibodies) during neuronal differentiation, which is independent of its previously known function in DNA damage response.
in mouse embryonic stem cells, Dnmt3b-dependent intragenic DNA methylation protects the gene body from spurious RNA polymerase II entry and cryptic transcription initiation
three DNA methyltransferases, Dnmt1 (show DNMT1 Antibodies), Dnmt3a (show DNMT3A Antibodies), and Dnmt3b, have been identified. Dnmt3a (show DNMT3A Antibodies) and Dnmt3b are responsible for establishing DNA methylation (show HELLS Antibodies) patterns produced through their de novo-type DNA methylation (show HELLS Antibodies) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (show TRDMT1 Antibodies)), which is a member of the Dnmt3 family but does not possess DNA methylation (show HELLS Antibodies)
While lens epithelial cell survival requires DNMT1 (show DNMT1 Antibodies), morphologically normal lenses develop in the absence of both DNMT3A (show DNMT3A Antibodies) and DNMT3B.
Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b.
a miR (show MLXIP Antibodies)-125b-DNMT3b-p53 (show TP53 Antibodies) signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine.
miR (show MLXIP Antibodies)-29a mimic transfection lowered collagen 1alpha1, DNMT1 (show DNMT1 Antibodies), DNMT3b and SET1A (show SETD1A Antibodies) expression in hepatic stellate cells.
Loss of DNMT3B results in hypomethylation of the miR (show MLXIP Antibodies)-196b promoter and increased miR (show MLXIP Antibodies)-196b expression, which directly targets the mTORC2 (show CRTC2 Antibodies) component Rictor (show RICTOR Antibodies).
The findings define PRMT7 (show PRMT7 Antibodies) as a regulator of the DNMT3b/p21 (show D4S234E Antibodies) axis required to maintain muscle stem cell regenerative capacity.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
DNA (cytosine-5)-methyltransferase 3B
, DNA (cytosine-5-)-methyltransferase 3 beta
, DNA cytosine-5 methyltransferase 3 beta
, DNA (cytosine-5)-methyltransferase 3B-like
, DNA methyl transferase beta
, DNA methyltransferase 3B
, DNA MTase HsaIIIB
, DNA methyltransferase HsaIIIB
, DNA (cytosine-5-)-methyltransferase 3 beta, like
, DNA (cytosine-5-)-methyltransferase 7
, DNA MTase MmuIIIB
, DNA methyltransferase MmuIIIB