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DCLRE1A encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. Additionally we are shipping and many more products for this protein.
Showing 10 out of 38 products:
Human Polyclonal DCLRE1A Primary Antibody for ELISA, WB - ABIN185226
Richie, Peterson, Lu, Hittelman, Carpenter, Legerski: hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage. in Molecular and cellular biology 2002
Human Polyclonal DCLRE1A Primary Antibody for ELISA, WB - ABIN185528
Akhter, Richie, Deng, Brey, Zhang, Patrick, Behringer, Legerski: Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. in Molecular and cellular biology 2004
Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction.
Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B (show DCLRE1B Antibodies).
differences in the substrate selectivities of SNM1A and SNM1B (show DCLRE1B Antibodies) are likely to be relevant to their in vivo roles
collaboration between hSNM1A and XPF (show ERCC4 Antibodies)-ERCC1 (show ERCC1 Antibodies) is necessary to initiate interstrand cross-link repair in replicating human cells
RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger
Results suggest that 53BP1 and Snm1 may cooperate in the cellular response to genotoxic damage.
Snm1 and 53BP1 (show TP53BP1 Antibodies) are components of a mitotic stress checkpoint that negatively targets the APC (show APC Antibodies) prior to chromosome condensation
The SNM1 enzyme utilizes either DNA or RNA substrates, requires a 5'-phosphate moiety, shows very little activity on double-strand substrates, and functions at a size consistent with a monomer.
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.
hSNM1 appears to represent a second pathway for genome stability
Snm1 is a tumor suppressor in mice that in addition has a role in immunity
This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants.
DNA cross-link repair 1A
, DNA cross-link repair 1A protein-like
, DNA cross-link repair 1A protein
, DNA-crosslink repair gene SNM1
, SNM1 homolog A
, DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)