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HELB encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. Additionally we are shipping DNA Helicase B Proteins (3) and many more products for this protein.
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Human Polyclonal HELB Primary Antibody for WB - ABIN2775262
Taneja, Gu, Peng, Carrick, Uchiumi, Ott, Gustafson, Podust, Fanning: A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication. in The Journal of biological chemistry 2002
Conclude that mammalian DNA end resection triggers its own inhibition via the recruitment of HELB.
HDHB promotes homologous recombination in vivo and stimulates 5'-3' heteroduplex extension during Rad51 (show RAD51 Antibodies)-mediated strand exchange in vitro
The depletion of HDHB from human cells diminishes Cdc45 (show CDC45 Antibodies) association with chromatin, suggesting that HDHB may facilitate Cdc45 (show CDC45 Antibodies) recruitment at G1/S in human cells.
Replication stress-induced recruitment of HDHB to chromatin is independent of checkpoint signaling but correlates with the level of replication protein A (RPA (show RPA1 Antibodies)) recruited to chromatin.
This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle.
DNA helicase B