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DMAP1 encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. Additionally we are shipping DNA Methyltransferase 1-Associated Protein 1 Antibodies (60) and DNA Methyltransferase 1-Associated Protein 1 Proteins (4) and many more products for this protein.
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A novel tumour suppressor gene, MDGA2 (show MDGA2 ELISA Kits), which is frequently inactivated by promoter methylation in Gastric cancer, exerts a tumour suppressive function by cooperating with DMAP1 to activate the p53 (show TP53 ELISA Kits)/p21 (show CDKN1A ELISA Kits) signalling cascade.
Targeted knockdown of human DNA methyltransferase 1 (show DNMT1 ELISA Kits) expression restores the expression levels of tumor suppressor genes, thus inhibiting the proliferation of cholangiocarcinoma cell line cells.
These results suggest that DMAP1 is a critical regulator of ATM (show ATM ELISA Kits) activity and function
positive staining for DNMT1 (show DNMT1 ELISA Kits) in clinical cancer specimens was significantly linked to lower rates of response to treatments and shorter survival of patients with pharyngeal cancer.
Knocking down DMAP1 caused hypomethylation of the DNA repair products.
MMTR is an intrinsic negative cell cycle regulator that modulates the CAK (show CCNH ELISA Kits) kinase activity via interaction with MAT1 (show MAT1A ELISA Kits).
RGS6 (show RGS6 ELISA Kits) inhibited the transcriptional repressor activity of DMAP1.
Localization of DNA methyltransferase-1 (show DNMT1 ELISA Kits) during oocyte differentiation, in vitro maturation and early embryonic development in cow.(
Consistent with the phenotypes of loss of other members of the TIP60 (show KAT5 ELISA Kits)-p400 (show ITPR1 ELISA Kits) complex, Dmap1(-/-) mice died during preimplantation in both Dnmt1 (show DNMT1 ELISA Kits)(+/+) and Dnmt1 (show DNMT1 ELISA Kits)(V)(/)(V) backgrounds.
Dmap1 plays a crucial role in DNA repair, and is indispensable for the maintenance of chromosomal integrity
In this study, two-hybrid screening leads to the identification of DNMT1 (show DNMT1 ELISA Kits) associated protein, DMAP1, as a Daax-interacting protein.
Findings suggest that Bmi1 (show BMI1 ELISA Kits) incorporates Dmap1 in polycomb (show CBX2 ELISA Kits) gene silencing.
Data suggest that MAT1-mediated transcriptional repressor (MMTR) is part of the basic cellular machinery for a wide range of transcriptional regulation via interaction with TFIIH and HDAC1 (show HDAC1 ELISA Kits).
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
DNA methyltransferase 1-associated protein DMAP1
, DNA methyltransferase 1-associated protein 1
, DNA methyltransferase 1 associated protein 1
, DNMT1 associated protein 1
, DNMT1-associated protein 1
, DNMT1 associated protein-1
, MAT1-mediated transcriptional repressor