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This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Additionally we are shipping DNMT3B Kits (7) and and many more products for this protein.
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Loss of DNMT3B results in hypomethylation of the miR (show MLXIP Antibodies)-196b promoter and increased miR (show MLXIP Antibodies)-196b expression, which directly targets the mTORC2 (show CRTC2 Antibodies) component Rictor (show RICTOR Antibodies).
The findings define PRMT7 (show PRMT7 Antibodies) as a regulator of the DNMT3b/p21 (show D4S234E Antibodies) axis required to maintain muscle stem cell regenerative capacity.
These results demonstrate that Dnmt1 (show DNMT1 Antibodies) and Dnmt3b cooperate to maintain DNA methylation (show HELLS Antibodies) and genomic integrity in the intestinal epithelium.
Downregulation of DNMT3B, one of the targets identified using this method, radiosensitizes cancer cells by disturbing multiple DNA damage responses.
High levels of Dnmt3b expression prolong leukemia latency.
The expression of DNMT1 (show DNMT1 Antibodies) and DNMT3b was decreased at 1 mT, and 50 Hz ELF (show SPTBN1 Antibodies)-EMF can increase the expression...the alterations of genome-wide methylation and DNMTs expression may play an important role in the biological effects of 50 Hz ELF (show SPTBN1 Antibodies)-EMF exposure
DKO cardiomyocytes showed virtual absence of targeted Dnmt3a (show DNMT3A Antibodies) and Dnmt3b mRNA transcripts.
An unexpected oncogenic role for Dnmt3a (show DNMT3A Antibodies) in MTCL through methylation-independent repression of Dnmt3b.
we report that cardiac specific deletion of Dnmt3b, the predominant DNA methyltransferase (show DNMT1 Antibodies) in adult mouse hearts, leads to an accelerated progression to severe systolic insufficiency and myocardial thinning without a preceding hypertrophic response.
These results indicated a role for the miR29b-Dnmt3a (show DNMT3A Antibodies)/3b-DNA methylation (show HELLS Antibodies) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
DNA (cytosine-5)-methyltransferase 3B
, DNA methyltransferase 3B
, DNA MTase MmuIIIB
, DNA methyltransferase MmuIIIB