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DDIT3 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. Additionally we are shipping DDIT3 Kits (28) and DDIT3 Proteins (20) and many more products for this protein.
Showing 10 out of 197 products:
Human Monoclonal DDIT3 Primary Antibody for GS, ICC - ABIN269517
Hull, Zraika, Udayasankar, Aston-Mourney, Subramanian, Kahn: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. in Diabetologia 2009
Show all 15 references for ABIN269517
Mouse (Murine) Polyclonal DDIT3 Primary Antibody for FACS, IF - ABIN655895
Park, Choi, Yang, Do, Kim, Moon: Repression of peroxisome proliferator-activated receptor gamma by mucosal ribotoxic insult-activated CCAAT/enhancer-binding protein homologous protein. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 3 references for ABIN655895
Human Polyclonal DDIT3 Primary Antibody for EIA, WB - ABIN952423
Goodall, Wu, Zhang, McNeill, Ellis, Saudek, Gaston: Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 3 references for ABIN952423
Human Polyclonal DDIT3 Primary Antibody for EIA, FACS - ABIN952424
Zhang, Ye, Su, Yuan, Liu, Stein, Yang: Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. in Journal of virology 2010
Show all 3 references for ABIN952424
Human Polyclonal DDIT3 Primary Antibody for IF, IHC - ABIN1531556
Park, Luethy, Wang, Fargnoli, Fornace, McBride, Holbrook: Isolation, characterization and chromosomal localization of the human GADD153 gene. in Gene 1992
Show all 3 references for ABIN1531556
Human Polyclonal DDIT3 Primary Antibody for IF (p), IHC (p) - ABIN685447
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
Show all 2 references for ABIN685447
Human Polyclonal DDIT3 Primary Antibody for IP, IHC - ABIN223141
Zenkel, Kruse, Naumann, Schlötzer-Schrehardt: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. in Investigative ophthalmology & visual science 2007
Deletion of CHOP attenuates dysfunction of the autophagy/lysosomal pathway in beta-cells of transgenic mice.
Interference with DOT1L (show DOT1L Antibodies) activity resulted in transcriptional activation of Atf4 (show ATF4 Antibodies) and Ddit3 accompanied by decreased levels of H3K79 dimethylation.
this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK (show EIF2AK3 Antibodies) and a downstream effector of its activation, CHOP, in tubule cell production of fibronectin (show FN1 Antibodies)
CHOP regulates not only apoptosis-related signaling but also ROS (show ROS1 Antibodies) formation and inflammation in renal tubular cells during ischemia/reperfusion (I/R). CHOP may play an important role in the pathophysiology of I/R-induced renal injury.
As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.
TFEB (show TFEB Antibodies)-regulated signaling pathway for osteoblast differentiation is involved in ATF4 (show ATF4 Antibodies)/CHOP-dependent signaling pathway.
CHOP expression in myeloid cells plays an important role in determining the magnitude and duration of inflammatory response in vivo by modulating expression of proinflammatory cytokines such as IL-6 (show IL6 Antibodies) in infiltrating macrophages.
the ER stress-induced transcription factor, CHOP, at least in part, plays an important role in the development of bleomycin-induced pulmonary fibrosis
Data indicate that transcription factor Chop does not play a significant causal role during retinal degeneration.
Upregulation of PD-1 (show PDCD1 Antibodies) and PD-L1 (show CD274 Antibodies) was associated with marked increases in GADD153 during myocardial ischemic reperfusion injury.
plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 Antibodies)), protein kinase (show CDK7 Antibodies) R (PKR (show PKLR Antibodies))like ER kinase (PERK (show EIF2AK3 Antibodies)), and inositolrequiring enzyme 1 (IRE1 (show ERN1 Antibodies)). Elevated expression of spliced Xbox binding protein 1 (XBP1 (show XBP1 Antibodies)) and CCAAT/enhancerbinding protein homologous protein (CHOP) further confirmed that ROS (show ROS1 Antibodies) generatedby NTGP induces apoptosis through the ER stress
High DDIT3 expression is associated with non-small-cell lung cancer.
CAPE/TRAIL stimulated apoptosis through the binding of TRAIL to DR5 (show TNFRSF10B Antibodies). Moreover, expression of transcription factor C/EBP homologous protein (CHOP) markedly increased in response to CAPE and transient knockdown of CHOP abolished CAPE/TRAIL-mediated apoptosis.
the C/EBPD (show CEBPD Antibodies) binding site is required for RU486-mediated activation of the CHOP promoter.
Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Antibodies) formation upstream of AMP-activated protein kinase (show PRKAA2 Antibodies) and protein kinase (show CDK7 Antibodies) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein pathways and p21 Cip1 (show CDKN1A Antibodies) expression.
Data suggest that HOXA-AS2 (show ARSA Antibodies) could be an oncogene (show RAB1A Antibodies) for GC partly through suppressing P21 (show CDKN1A Antibodies), PLK3 (show PLK3 Antibodies), and DDIT3 expression.
FUS (show FUS Antibodies)-DDIT3 is uniquely regulated at the transcriptional as well as the post-translational level and that its expression level is important for myxoid liposarcoma tumour development.
CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK (show EIF2AK3 Antibodies)/CHOP signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.
Combined administration inhibited the cells most potently and time-dependently, decreased the expression of HO-1 (show HMOX1 Antibodies), and significantly increased the expression of ATF4 (show ATF4 Antibodies), CHOP, and Ire-1 (show ERN1 Antibodies) proteins expression levels
Blockage of PERK (show EIF2AK3 Antibodies) signaling expression by siRNA not only significantly reduced the expression of CHOP.
CHOP (GADD153) is an inhibitor of Wnt (show WNT2 Antibodies)/TCF (show HNF4A Antibodies) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3