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DNA-Damage-Inducible Transcript 3 Proteins (DDIT3)

DDIT3 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. Additionally we are shipping DDIT3 Antibodies (170) and DDIT3 Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DDIT3 13198 P35639
DDIT3 29467  
DDIT3 1649 P35638
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Top DDIT3 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$756.80
Details
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
$2,387.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,387.00
Details
HOST_Escherichia coli (E. coli) Human GST tag   1 mg Log in to see 3 to 4 Days
$3,035.21
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$4,009.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$467.86
Details

DDIT3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)
Human ,
,

Top referenced DDIT3 Proteins

  1. Human DDIT3 Protein expressed in Escherichia coli (E. coli) - ABIN667718 : Oyadomari, Mori: Roles of CHOP/GADD153 in endoplasmic reticulum stress. in Cell death and differentiation 2004 (PubMed)
    Show all 2 references for ABIN667718

More Proteins for DNA-Damage-Inducible Transcript 3 (DDIT3) Interaction Partners

Mouse (Murine) DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK (show EIF2AK3 Proteins) and a downstream effector of its activation, CHOP, in tubule cell production of fibronectin (show FN1 Proteins)

  2. CHOP regulates not only apoptosis-related signaling but also ROS (show ROS1 Proteins) formation and inflammation in renal tubular cells during ischemia/reperfusion (I/R). CHOP may play an important role in the pathophysiology of I/R-induced renal injury.

  3. As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.

  4. TFEB (show TFEB Proteins)-regulated signaling pathway for osteoblast differentiation is involved in ATF4 (show ATF4 Proteins)/CHOP-dependent signaling pathway.

  5. CHOP expression in myeloid cells plays an important role in determining the magnitude and duration of inflammatory response in vivo by modulating expression of proinflammatory cytokines such as IL-6 (show IL6 Proteins) in infiltrating macrophages.

  6. the ER stress-induced transcription factor, CHOP, at least in part, plays an important role in the development of bleomycin-induced pulmonary fibrosis

  7. Data indicate that transcription factor Chop does not play a significant causal role during retinal degeneration.

  8. Upregulation of PD-1 (show PDCD1 Proteins) and PD-L1 (show CD274 Proteins) was associated with marked increases in GADD153 during myocardial ischemic reperfusion injury.

  9. Chop deficiency prevents unilateral ureteral obstruction-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1 (show HMGB1 Proteins)/TLR4 (show TLR4 Proteins)/NFkappaB/IL-1beta (show IL1B Proteins) signaling.

  10. findings suggest that the balance between XBP1 (show XBP1 Proteins)-mediated adaptive and CHOP-dependent apoptotic UPR is critically important for beta-cell survival during ER stress.

Human DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Proteins) formation upstream of AMP-activated protein kinase (show PRKAA2 Proteins) and protein kinase (show CDK7 Proteins) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein pathways and p21 Cip1 (show CDKN1A Proteins) expression.

  2. Data suggest that HOXA-AS2 (show ARSA Proteins) could be an oncogene (show RAB1A Proteins) for GC partly through suppressing P21 (show CDKN1A Proteins), PLK3 (show PLK3 Proteins), and DDIT3 expression.

  3. FUS (show FUS Proteins)-DDIT3 is uniquely regulated at the transcriptional as well as the post-translational level and that its expression level is important for myxoid liposarcoma tumour development.

  4. CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK (show EIF2AK3 Proteins)/CHOP signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.

  5. Combined administration inhibited the cells most potently and time-dependently, decreased the expression of HO-1 (show HMOX1 Proteins), and significantly increased the expression of ATF4 (show ATF4 Proteins), CHOP, and Ire-1 (show ERN1 Proteins) proteins expression levels

  6. Blockage of PERK (show EIF2AK3 Proteins) signaling expression by siRNA not only significantly reduced the expression of CHOP.

  7. Up-regulation of CHOP is associated with Pancreatic Neuroendocrine Tumors.

  8. knockdown of a proton-sensing G protein-coupled receptor (show ADRA1A Proteins) GPR4 (show GPR4 Proteins) markedly reduced CHOP expression and endothelial cell apoptosis after hypoxia exposure.

  9. These data show that altered/impaired expression of mtDNA induces CHOP-10 expression in a signaling pathway that depends on the eIF2alpha (show EIF2A Proteins)/ATF4 (show ATF4 Proteins) axis of the integrated stress response rather than on the mitochondrial unfolded protein response.

  10. In a GRP78 (show HSPA5 Proteins)-positive breast cancer subset, CHOP overexpression correlated with a lower risk of recurrence.

Xenopus laevis DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. CHOP (GADD153) is an inhibitor of Wnt (show WNT2 Proteins)/TCF (show HNF4A Proteins) signals

DDIT3 Protein Profile

Protein Summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Gene names and symbols associated with DDIT3

  • DNA-damage-inducible transcript 3 (ddit3)
  • DNA-damage inducible transcript 3 (Ddit3)
  • DNA-damage-inducible transcript 3 (DDIT3)
  • DNA-damage-inducible transcript 3 (Ddit3)
  • DNA-damage-inducible transcript 3 (LOC100338439)
  • CEBPZ protein
  • CHOP protein
  • CHOP-10 protein
  • Chop10 protein
  • GADD153 protein
  • Xchop protein

Protein level used designations for DDIT3

C/EBP homoologous protein 10 , C/EBP zeta , CCAAT/enhancer-binding protein homologous protein , DDIT-3 , DNA damage-inducible transcript 3 protein , c/EBP-homologous protein 10 , growth arrest and DNA-damage-inducible protein GADD153 , C/EBP homologous protein , growth arrest and DNA damage-inducible protein GADD153 , growth arrest and DNA damage-inducible , transcription factor GADD153 , C/EBP-homologous protein 10 , DNA-damage inducible transcript 3

GENE ID SPECIES
733816 Xenopus (Silurana) tropicalis
13198 Mus musculus
29467 Rattus norvegicus
1649 Homo sapiens
398615 Xenopus laevis
777788 Bos taurus
607439 Canis lupus familiaris
100857832 Gallus gallus
101787388 Cavia porcellus
100240743 Sus scrofa
100338439 Oryctolagus cuniculus
541600 Ovis aries
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