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anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antibodies

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. Additionally we are shipping DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DOT1L 84444 Q8TEK3
DOT1L 362831  
DOT1L 208266  
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Top anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Image DOT1L antibody detects DOT1L protein by Western blot analysis. A. H1299 whole cell lysate/extract % SDS-PAGE DOT1L antibody , dilution: 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ChIP, ICC, IF, IHC (p), IP, IHC, WB Western Blot and Immunoprecipitation: DOT1L Antibody [ABIN251529] - Detection of Human DOT1L by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DOT1L antibody ABIN251529 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). DOT1L was also immunoprecipitated by another rabbit anti-DOT1L antibody and ABIN251530, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). 0.1 mL Log in to see 5 to 7 Days
$477.75
Details
Human Rabbit Un-conjugated WB DOT1L antibody (pAb) tested by Western blot. Nuclear extract of HEK293 cells (40 µg per lane) probed with DOT1L antibody (pAb) at a dilution of 1:500. 100 μL Log in to see 1 to 2 Days
$466.67
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p)   100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p)   100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IP, IHC   100 μg Log in to see 8 to 10 Days
$793.83
Details
Human Rabbit Biotin IHC (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

DOT1L Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies

  1. Human Polyclonal DOT1L Primary Antibody for ChIP, ICC - ABIN251529 : Steger, Lefterova, Ying, Stonestrom, Schupp, Zhuo, Vakoc, Kim, Chen, Lazar, Blobel, Vakoc: DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. in Molecular and cellular biology 2008 (PubMed)
    Show all 5 references for ABIN251529

More Antibodies against DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Interaction Partners

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. Report drug formulation/delivery of DOT1L inhibitor pinometostat in leukemia.

  2. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Antibodies).

  3. These data converge on a possible mechanism for hDot1L stimulation in which histone H2B physically 'corrals' the enzyme into a productive binding orientation.

  4. analysis of a functional hotspot on ubiquitin that is required for the stimulation of human Dot1

  5. Three candidate variants were identified: p.Glu1313Lys in Insulin receptor (INSR (show INSR Antibodies)), p.Arg81Pro in F-box protein 24 (FBXO24 (show FBXO24 Antibodies)) and p.Pro1146Leu in DOT1-like histone H3K79 methyltransferase

  6. The graded reduction of the DOT1L interaction with MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) results in differential loss of H3K79me2 and me3 (show ME3 Antibodies) at MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) target genes.

  7. The PZP (show PZP Antibodies) domain of AF10 (show MLLT10 Antibodies) senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79.

  8. Targeting DOT1L and HOX (show MSH2 Antibodies) gene expression in MLL (show MLL Antibodies)-rearranged leukemia and beyond.

  9. A genome-wide association study identifies PLCL2 (show PLCL2 Antibodies) and AP3D1 (show AP3D1 Antibodies)-DOT1L-SF3A2 (show SF3A2 Antibodies) as new susceptibility loci for myocardial infarction in Japanese

  10. DOT1L rs12982744 G to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Antibodies).

  2. DOT1L has a role in inhibiting SIRT1 (show SIRT1 Antibodies)-mediated epigenetic silencing to maintain leukemic gene expression in MLL (show MLL Antibodies)-rearranged leukemia

  3. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.

  4. Results provide evidence that transformation driven by MLL (show MLL Antibodies) fusions as well as the recurrent AML (show RUNX1 Antibodies)-associated NUP98 (show NUP98 Antibodies)-NSD1 (show NSD1 Antibodies) fusion oncogene (show RAB1A Antibodies) is critically dependent on the ability of AF10 (show MLLT10 Antibodies) to stimulate DOT1L activity.

  5. The cytological distribution of the evolutionarily conserved DOT1L methyltransferase and the different H3K79 methylation states resulting from its activity during meiotic prophase I in mouse spermatocytes.

  6. The absence of DOT1L, which is involved in the formation of a specific configuration of heterochromatin at the two-cell stage, is essential for early preimplantation development (show MTA2 Antibodies).

  7. Impaired alphaENaC (show SCNN1A Antibodies) expression due to failure to inhibit Dot1a-Af9 (show MLLT3 Antibodies) may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  8. Our data suggest that DOT1L secures an open chromatin structure in order to reactivate RNA Pol II (show POLR2F Antibodies) transcription initiation after a genotoxic attack.

  9. Therefore, Dot1a and Af9 (show MLLT3 Antibodies) as aldosterone-downregulated targets are negative regulators of endothelin-1 (show EDN1 Antibodies) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  10. Upregulated Aqp5 (show AQP5 Antibodies) may contribute to polyuria, possibly by impairing Aqp2 (show AQP2 Antibodies) membrane localization, in Dot1l(AC) mice and in patients with diabetic nephropathy.

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antigen Profile

Protein Summary

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Gene names and symbols associated with DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (Dot1l) antibody
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L) antibody
  • C terminus is similar to that of S. cerevisiae DOT1 (YDR440W) nucleosomal histone H3-Lys79 methylase involved in meiosis and transcriptional silencing (DOT1) antibody
  • DOT1-like histone H3K79 methyltransferase (DOT1L) antibody
  • DOT1-like histone H3K79 methyltransferase (Dot1l) antibody
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l) antibody
  • A630076O07 antibody
  • AW907654 antibody
  • Dot1 antibody
  • DOT1L antibody
  • KMT4 antibody
  • mDot1 antibody
  • NV11307 antibody

Protein level used designations for DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPECIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
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