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DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins (DOT1L)

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. Additionally we are shipping DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DOT1L 84444 Q8TEK3
Rat DOT1L DOT1L 362831  
Mouse DOT1L DOT1L 208266  
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Top DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human GST tag 25 μg Log in to see 2 to 3 Days
$262.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag DOT1L (1-416), active activity assay using Recombinant Nucleosomes as substrates. Recombinant Nucleosomes were used as substrates in an assay measuring the methyltransferase activity of DOT1L (1-416), active. Activity was detected by fluorography. Recombinant DOT1L (1-416), active protein gel. Recombinant DOT1L (1-416), active run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Log in to see 1 to 2 Days
$460.83
Details
Yeast Aspergillus oryzae His tag   1 mg Log in to see 56 to 66 Days
$2,905.83
Details

DOT1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Top referenced DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins

  1. Human DOT1L Protein expressed in Escherichia coli (E. coli) - ABIN2004356 : Feng, Wang, Ng, Erdjument-Bromage, Tempst, Struhl, Zhang: Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. in Current biology : CB 2002 (PubMed)
    Show all 3 references for ABIN2004356

More Proteins for DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Interaction Partners

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. Report drug formulation/delivery of DOT1L inhibitor pinometostat in leukemia.

  2. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).

  3. These data converge on a possible mechanism for hDot1L stimulation in which histone H2B physically 'corrals' the enzyme into a productive binding orientation.

  4. analysis of a functional hotspot on ubiquitin that is required for the stimulation of human Dot1

  5. Three candidate variants were identified: p.Glu1313Lys in Insulin receptor (INSR (show INSR Proteins)), p.Arg81Pro in F-box protein 24 (FBXO24 (show FBXO24 Proteins)) and p.Pro1146Leu in DOT1-like histone H3K79 methyltransferase

  6. The graded reduction of the DOT1L interaction with MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) results in differential loss of H3K79me2 and me3 at MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) target genes.

  7. The PZP (show PZP Proteins) domain of AF10 (show MLLT10 Proteins) senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79.

  8. Targeting DOT1L and HOX (show MSH2 Proteins) gene expression in MLL (show MLL Proteins)-rearranged leukemia and beyond.

  9. A genome-wide association study identifies PLCL2 (show PLCL2 Proteins) and AP3D1-DOT1L-SF3A2 (show SF3A2 Proteins) as new susceptibility loci for myocardial infarction in Japanese

  10. DOT1L rs12982744 G to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).

  2. DOT1L has a role in inhibiting SIRT1 (show SIRT1 Proteins)-mediated epigenetic silencing to maintain leukemic gene expression in MLL (show MLL Proteins)-rearranged leukemia

  3. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.

  4. Results provide evidence that transformation driven by MLL (show MLL Proteins) fusions as well as the recurrent AML (show RUNX1 Proteins)-associated NUP98 (show NUP98 Proteins)-NSD1 fusion oncogene (show RAB1A Proteins) is critically dependent on the ability of AF10 (show MLLT10 Proteins) to stimulate DOT1L activity.

  5. The cytological distribution of the evolutionarily conserved DOT1L methyltransferase and the different H3K79 methylation states resulting from its activity during meiotic prophase I in mouse spermatocytes.

  6. The absence of DOT1L, which is involved in the formation of a specific configuration of heterochromatin at the two-cell stage, is essential for early preimplantation development (show MTA2 Proteins).

  7. Impaired alphaENaC (show SCNN1A Proteins) expression due to failure to inhibit Dot1a-Af9 (show MLLT3 Proteins) may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  8. Our data suggest that DOT1L secures an open chromatin structure in order to reactivate RNA Pol II (show POLR2F Proteins) transcription initiation after a genotoxic attack.

  9. Therefore, Dot1a and Af9 (show MLLT3 Proteins) as aldosterone-downregulated targets are negative regulators of endothelin-1 (show EDN1 Proteins) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  10. Upregulated Aqp5 (show AQP5 Proteins) may contribute to polyuria, possibly by impairing Aqp2 (show AQP2 Proteins) membrane localization, in Dot1l(AC) mice and in patients with diabetic nephropathy.

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Protein Profile

Protein Summary

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Gene names and symbols associated with DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (Dot1l)
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L)
  • C terminus is similar to that of S. cerevisiae DOT1 (YDR440W) nucleosomal histone H3-Lys79 methylase involved in meiosis and transcriptional silencing (DOT1)
  • DOT1-like histone H3K79 methyltransferase (DOT1L)
  • DOT1-like histone H3K79 methyltransferase (Dot1l)
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l)
  • A630076O07 protein
  • AW907654 protein
  • Dot1 protein
  • DOT1L protein
  • KMT4 protein
  • mDot1 protein
  • NV11307 protein

Protein level used designations for DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPECIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
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