anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antibodies

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. Additionally we are shipping DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins (5) and DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DOT1L 84444 Q8TEK3
DOT1L 362831  
DOT1L 208266  
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Top anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies at antibodies-online.com

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ChIP, ICC, IF, IHC (p), IP, IHC, WB Western Blot and Immunoprecipitation: DOT1L Antibody [ABIN251529] - Detection of Human DOT1L by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DOT1L antibody ABIN251529 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). DOT1L was also immunoprecipitated by another rabbit anti-DOT1L antibody and ABIN251530, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). Immunohistochemistry-Paraffin: DOT1L Antibody [ABIN2515295] - FFPE section of human colon carcinoma.. 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP Western Blot: DOT1L Antibody [ABIN251530] - Detection of Human DOT1L by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DOT1L antibody ABIN251530 used for IP at 3 mcg/mg lysate. DOT1L was also immunoprecipitated by rabbit anti- DOT1L antibody ABIN251529, which recognizes an upstream epitope. Detection: Chemiluminescence with an exposure time 10 seconds. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated IHC (p) Formalin-fixed and paraffin embedded human kidney labeled with Anti-DOT1L Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated WB WB Image DOT1L antibody detects DOT1L protein by Western blot analysis. A. H1299 whole cell lysate/extract % SDS-PAGE DOT1L antibody , dilution: 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Mouse Un-conjugated IHC, WB Immunohistochemistry: DOT1L Antibody (6E7) [NBP2-46474] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Western Blot: DOT1L Antibody (6E7) [NBP2-46474] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit HRP IHC (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Un-conjugated WB DOT1L antibody (pAb) tested by Western blot. Nuclear extract of HEK293 cells (40 µg per lane) probed with DOT1L antibody (pAb) at a dilution of 1:500. 100 μL Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Biotin IHC (p)   100 μL Log in to see 14 to 21 Days
$383.90
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of HeLa cell line, using DOT1L antibody. 100 μL Log in to see 16 Days
$323.13
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 7 to 9 Days
$493.17
Details

DOT1L Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies

  1. Human Polyclonal DOT1L Primary Antibody for ChIP, ICC - ABIN251529 : Steger, Lefterova, Ying, Stonestrom, Schupp, Zhuo, Vakoc, Kim, Chen, Lazar, Blobel, Vakoc: DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. in Molecular and cellular biology 2008 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal DOT1L Primary Antibody for ICC, IF - ABIN251530 : Vernimmen, Lynch, De Gobbi, Garrick, Sharpe, Sloane-Stanley, Smith, Higgs: Polycomb eviction as a new distant enhancer function. in Genes & development 2011 (PubMed)

  3. Human Monoclonal DOT1L Primary Antibody for IF, ELISA - ABIN566567 : Phillips, Wildt, Comizzoli: Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis. in Journal of assisted reproduction and genetics 2016 (PubMed)

More Antibodies against DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Interaction Partners

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. our results identify DOT1L as a novel cofactor in N-Myc (show MYCN Antibodies)-mediated transcriptional activation of target genes and neuroblastoma (show ARHGEF16 Antibodies) oncogenesis. Furthermore, they characterize DOT1L inhibitors as novel anticancer agents against MYCN (show MYCN Antibodies)-amplified neuroblastoma (show ARHGEF16 Antibodies).

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (show LGMN Antibodies) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (show MLL Antibodies) fusion-AF4 complex and DOT1L for more effective treatment of MLL (show MLL Antibodies)-rearranged leukemia.

  3. this indicates that DOT1L function, like MLL (show MLL Antibodies), does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L inhibition is sufficient to block the proliferation of MLL (show MLL Antibodies) fusion-induced leukemia cells of murine and human origin

  4. DOT1L may play a critical role in DNMT3A (show DNMT3A Antibodies)-mutant leukemia.

  5. DOT1L, via dimethylated histone H3 (show HIST3H3 Antibodies) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 (show BRD4 Antibodies) to chromatin in acute lymphoblastic leukemia.

  6. study demonstrates the development of potent DOT1L inhibitors with novel scaffolds

  7. these findings strongly support the contention that histone methyltransferase, DOT1L-associated epigenetic changes induced by HA play pivotal roles in miR-10 (show LILRB2 Antibodies) production leading to up-regulation of RhoGTPase and survival proteins.

  8. Report drug formulation/delivery of DOT1L inhibitor pinometostat in leukemia.

  9. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Antibodies).

  10. These data converge on a possible mechanism for hDot1L stimulation in which histone H2B physically 'corrals' the enzyme into a productive binding orientation.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. We will highlight the structural basis of chromatin targeting of DOT1L through its cofactors and the role of DOT1L in repelling transcription repressive complexes during leukemia development.

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (show LGMN Antibodies) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (show MLL Antibodies) fusion-AF4 complex and DOT1L for more effective treatment of MLL (show MLL Antibodies)-rearranged leukemia.

  3. DOT1L may play a critical role in DNMT3A (show DNMT3A Antibodies)-mutant leukemia.

  4. DOT1L, via dimethylated histone H3 (show HIST3H3 Antibodies) K79, facilitates histone H4 (show HIST1H4H Antibodies) acetylation, which in turn regulates the binding of BRD4 (show BRD4 Antibodies) to chromatin in acute lymphoblastic leukemia.

  5. Dot1l is a new epigenetic regulator of principal cells and intercalated cell differentiation and Atp6v1b1 (show ATP6V1B1 Antibodies) is a new transcriptional target of Dot1l.

  6. results demonstrate that histone methylation, and in particular DOT1L-mediated H3K79me2 modification, drives cardiomyogenesis through the definition of a specific transcriptional landscape

  7. Interference with DOT1L activity resulted in transcriptional activation of Atf4 (show ATF4 Antibodies) and Ddit3 (show DDIT3 Antibodies) accompanied by decreased levels of H3K79 dimethylation.

  8. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Antibodies).

  9. DOT1L has a role in inhibiting SIRT1 (show SIRT1 Antibodies)-mediated epigenetic silencing to maintain leukemic gene expression in MLL (show MLL Antibodies)-rearranged leukemia

  10. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antigen Profile

Protein Summary

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Gene names and symbols associated with DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (Dot1l) antibody
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L) antibody
  • C terminus is similar to that of S. cerevisiae DOT1 (YDR440W) nucleosomal histone H3-Lys79 methylase involved in meiosis and transcriptional silencing (DOT1) antibody
  • DOT1-like histone H3K79 methyltransferase (DOT1L) antibody
  • DOT1-like histone H3K79 methyltransferase (Dot1l) antibody
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l) antibody
  • A630076O07 antibody
  • AW907654 antibody
  • Dot1 antibody
  • DOT1L antibody
  • KMT4 antibody
  • mDot1 antibody
  • NV11307 antibody

Protein level used designations for DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPECIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
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